Paternal occupation exposure and ras mutation among childhood ALL cases
| Paternal Occupational Exposure . | Exposure Period . | K-ras Mutation . | . | . | N-ras Mutation . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | . | −Cases (n = 567) . | +Cases (n = 32) . | Adjusted OR (95% CI) . | +Cases (n = 77) . | Adjusted OR (95% CI) . | |||
| Solvents, degreasers, or cleaning agents | Any time | 228 | 9 | 0.6 (0.3-1.4) | 33 | 0.9 (0.6-1.6) | |||
| Before pregnancy | 190 | 8 | 0.6 (0.3-1.5) | 26 | 0.9 (0.5-1.5) | ||||
| During pregnancy | 106 | 2 | 0.3 (0.1-1.2) | 15 | 0.8 (0.4-1.5) | ||||
| After pregnancy | 126 | 3 | 0.4 (0.1-1.4) | 15 | 0.6 (0.3-1.1) | ||||
| Plastic materials | Any time | 54 | 2 | 0.8 (0.2-3.4) | 12 | 1.7 (0.9-3.5) | |||
| Before pregnancy | 39 | 2 | 0.9 (0.2-4.3) | 11 | 2.4 (1.1-5.1) | ||||
| During pregnancy | 21 | 2 | 2.0 (0.4-10.0) | 6 | 2.2 (0.8-6.0) | ||||
| After pregnancy | 30 | 2 | 1.5 (0.3-7.1) | 8 | 2.2 (0.9-5.1) | ||||
| Paints or thinners | Any time | 235 | 13 | 1.0 (0.5-2.1) | 37 | 1.2 (0.8-2.0) | |||
| Before pregnancy | 182 | 12 | 1.2 (0.6-2.7) | 25 | 1.0 (0.6-1.7) | ||||
| During pregnancy | 102 | 7 | 1.3 (0.5-3.3) | 12 | 0.7 (0.4-1.5) | ||||
| After pregnancy | 131 | 8 | 1.2 (0.5-3.0) | 21 | 1.1 (0.6-2.0) | ||||
| Oil or coal products | Any time | 300 | 16 | 0.7 (0.3-1.7) | 42 | 0.9 (0.5-1.5) | |||
| Before pregnancy | 254 | 15 | 1.0 (0.5-2.3) | 40 | 1.2 (0.7-2.0) | ||||
| During pregnancy | 155 | 9 | 0.9 (0.4-2.3) | 25 | 1.1 (0.6-1.9) | ||||
| After pregnancy | 199 | 10 | 0.8 (0.3-1.8) | 27 | 0.8 (0.5-1.4) | ||||
| Other hydrocarbons | Any time | 205 | 7 | 0.5 (0.2-1.2) | 35 | 1.3 (0.8-2.2) | |||
| Before pregnancy | 168 | 7 | 0.7 (0.3-1.6) | 27 | 1.2 (0.7-2.0) | ||||
| During pregnancy | 97 | 2 | 0.3 (0.1-1.1) | 19 | 1.5 (0.8-2.6) | ||||
| After pregnancy | 119 | 2 | 0.2 (0.1-0.9) | 26 | 1.8 (1.0-3.1) | ||||
| Any hydrocarbons | Any time | 410 | 19 | 0.5 (0.2-1.2) | 61 | 1.3 (0.7-2.4) | |||
| Before pregnancy | 377 | 17 | 0.5 (0.2-1.1) | 55 | 1.1 (0.6-2.0) | ||||
| During pregnancy | 255 | 14 | 0.8 (0.4-1.8) | 39 | 1.1 (0.6-1.8) | ||||
| After pregnancy | 301 | 15 | 0.7 (0.3-1.5) | 45 | 1.0 (0.6-1.7) | ||||
| Paternal Occupational Exposure . | Exposure Period . | K-ras Mutation . | . | . | N-ras Mutation . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | . | −Cases (n = 567) . | +Cases (n = 32) . | Adjusted OR (95% CI) . | +Cases (n = 77) . | Adjusted OR (95% CI) . | |||
| Solvents, degreasers, or cleaning agents | Any time | 228 | 9 | 0.6 (0.3-1.4) | 33 | 0.9 (0.6-1.6) | |||
| Before pregnancy | 190 | 8 | 0.6 (0.3-1.5) | 26 | 0.9 (0.5-1.5) | ||||
| During pregnancy | 106 | 2 | 0.3 (0.1-1.2) | 15 | 0.8 (0.4-1.5) | ||||
| After pregnancy | 126 | 3 | 0.4 (0.1-1.4) | 15 | 0.6 (0.3-1.1) | ||||
| Plastic materials | Any time | 54 | 2 | 0.8 (0.2-3.4) | 12 | 1.7 (0.9-3.5) | |||
| Before pregnancy | 39 | 2 | 0.9 (0.2-4.3) | 11 | 2.4 (1.1-5.1) | ||||
| During pregnancy | 21 | 2 | 2.0 (0.4-10.0) | 6 | 2.2 (0.8-6.0) | ||||
| After pregnancy | 30 | 2 | 1.5 (0.3-7.1) | 8 | 2.2 (0.9-5.1) | ||||
| Paints or thinners | Any time | 235 | 13 | 1.0 (0.5-2.1) | 37 | 1.2 (0.8-2.0) | |||
| Before pregnancy | 182 | 12 | 1.2 (0.6-2.7) | 25 | 1.0 (0.6-1.7) | ||||
| During pregnancy | 102 | 7 | 1.3 (0.5-3.3) | 12 | 0.7 (0.4-1.5) | ||||
| After pregnancy | 131 | 8 | 1.2 (0.5-3.0) | 21 | 1.1 (0.6-2.0) | ||||
| Oil or coal products | Any time | 300 | 16 | 0.7 (0.3-1.7) | 42 | 0.9 (0.5-1.5) | |||
| Before pregnancy | 254 | 15 | 1.0 (0.5-2.3) | 40 | 1.2 (0.7-2.0) | ||||
| During pregnancy | 155 | 9 | 0.9 (0.4-2.3) | 25 | 1.1 (0.6-1.9) | ||||
| After pregnancy | 199 | 10 | 0.8 (0.3-1.8) | 27 | 0.8 (0.5-1.4) | ||||
| Other hydrocarbons | Any time | 205 | 7 | 0.5 (0.2-1.2) | 35 | 1.3 (0.8-2.2) | |||
| Before pregnancy | 168 | 7 | 0.7 (0.3-1.6) | 27 | 1.2 (0.7-2.0) | ||||
| During pregnancy | 97 | 2 | 0.3 (0.1-1.1) | 19 | 1.5 (0.8-2.6) | ||||
| After pregnancy | 119 | 2 | 0.2 (0.1-0.9) | 26 | 1.8 (1.0-3.1) | ||||
| Any hydrocarbons | Any time | 410 | 19 | 0.5 (0.2-1.2) | 61 | 1.3 (0.7-2.4) | |||
| Before pregnancy | 377 | 17 | 0.5 (0.2-1.1) | 55 | 1.1 (0.6-2.0) | ||||
| During pregnancy | 255 | 14 | 0.8 (0.4-1.8) | 39 | 1.1 (0.6-1.8) | ||||
| After pregnancy | 301 | 15 | 0.7 (0.3-1.5) | 45 | 1.0 (0.6-1.7) | ||||