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Table 4

Association between MTHFR genotypes and colon cancer risk, stratified by hormone replacement therapy (postmenopausal women)a

Recent hormone replacement therapyMTHFR 677MTHFR 1298
AAACCC
Cases (n)Ctrls (n)Odds ratio95% confidence intervalCases (n)Ctrls (n)Odds ratio95% confidence intervalCases (n)Ctrls (n)Odds ratio95% confidence interval
No CC 70 61 1.0 — 107 120 0.8 (0.5–1.2) 35 76 0.4 (0.2–0.7) 
 CT 115 127 0.8 (0.5–1.2) 92 100 0.8 (0.5–1.3)     
 TT 46 64 0.6 (0.4–1.1)         
Yes CC 10 31 0.3 (0.1–0.6) 41 61 0.6 (0.3–1.0) 12 23 0.5 (0.2–1.1) 
 CT 33 58 0.5 (0.3–0.9) 31 43 0.6 (0.4–1.1)     
 TT 17 26 0.6 (0.3–1.2)         
Recent hormone replacement therapyMTHFR 677MTHFR 1298
AAACCC
Cases (n)Ctrls (n)Odds ratio95% confidence intervalCases (n)Ctrls (n)Odds ratio95% confidence intervalCases (n)Ctrls (n)Odds ratio95% confidence interval
No CC 70 61 1.0 — 107 120 0.8 (0.5–1.2) 35 76 0.4 (0.2–0.7) 
 CT 115 127 0.8 (0.5–1.2) 92 100 0.8 (0.5–1.3)     
 TT 46 64 0.6 (0.4–1.1)         
Yes CC 10 31 0.3 (0.1–0.6) 41 61 0.6 (0.3–1.0) 12 23 0.5 (0.2–1.1) 
 CT 33 58 0.5 (0.3–0.9) 31 43 0.6 (0.4–1.1)     
 TT 17 26 0.6 (0.3–1.2)         
a

Adjusted for age, body mass index, lifetime vigorous activity, energy intake, diet fiber, calcium, usual number of cigarettes smoked. Relative excess risk due to interaction P < 0.01. Wald χ2 test of slopes, A1298C/HRT use relationship P = 0.04. Wald χ2 test of slopes, C677T/HRT use relationship P = 0.09.

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