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Table 2

Association between MTHFR genotype and colon cancer risk stratified by sex and agea,b

MTHFR 677AAMTHFR 1298 ACCC
Cases (n)Controls (n)ORc95% CICases (n)Controls (n)OR95% CICases (n)Controls (n)OR95% CI
Men             
  CC 131 145 1.0 — 178 217 0.9 (0.6–1.2) 93 103 1.0 (0.7–1.4) 
  CT 211 236 1.0 (0.7–1.3) 201 215 1.0 (0.7–1.4)     
  TT 78 123 0.7 (0.5–1.0)         
 Age of diagnosis/selection <65 years             
  CC 52 66 1.0 — 70 89 1.0 (0.6–1.6) 38 34 1.3 (0.7–2.4) 
  CT 82 107 0.9 (0.5–1.4) 102 92 1.3 (0.8–2.1)     
  TT 32 37 1.1 (0.6–2.0)         
 Age of diagnosis/selection 65–79 years             
  CC 79 79 1.0 — 108 128 0.8 (0.5–1.2) 55 69 0.8 (0.5–1.3) 
  CT 129 129 1.1 (0.7–1.6) 99 123 0.9 (0.6–1.3)     
  TT 46 86 0.6 (0.3–0.9)         
  P interaction, age category and MTHFR genotype = 0.34             
Women             
  CC 89 102 1.0 — 178 206 1.0 (0.7–1.4) 60 113 0.6 (0.4–0.9) 
  CT 171 217 0.9 (0.6–1.3) 134 184 0.9 (0.6–1.2)     
  TT 71 103 0.8 (0.5–1.2)         
 Age of diagnosis/selection <65 years             
  CC 38 47 1.0 — 78 72 1.4 (0.8–2.4) 21 39 0.7 (0.3–1.4) 
  CT 72 88 1.1 (0.6–1.8) 52 81 0.9 (0.5–1.7)     
  TT 27 38 1.0 (0.5–1.9)         
 Age of diagnosis/selection 65–79 years             
  CC 51 55 1.0 — 100 134 0.8 (0.5–1.3) 39 74 0.6 (0.3–1.0) 
  CT 99 129 0.8 (0.5–1.3) 82 103 0.8 (0.5–1.4)     
  TT 44 65 0.7 (0.4–1.2)         
  P interaction, age category and MTHFR genotype = 0.86             
MTHFR 677AAMTHFR 1298 ACCC
Cases (n)Controls (n)ORc95% CICases (n)Controls (n)OR95% CICases (n)Controls (n)OR95% CI
Men             
  CC 131 145 1.0 — 178 217 0.9 (0.6–1.2) 93 103 1.0 (0.7–1.4) 
  CT 211 236 1.0 (0.7–1.3) 201 215 1.0 (0.7–1.4)     
  TT 78 123 0.7 (0.5–1.0)         
 Age of diagnosis/selection <65 years             
  CC 52 66 1.0 — 70 89 1.0 (0.6–1.6) 38 34 1.3 (0.7–2.4) 
  CT 82 107 0.9 (0.5–1.4) 102 92 1.3 (0.8–2.1)     
  TT 32 37 1.1 (0.6–2.0)         
 Age of diagnosis/selection 65–79 years             
  CC 79 79 1.0 — 108 128 0.8 (0.5–1.2) 55 69 0.8 (0.5–1.3) 
  CT 129 129 1.1 (0.7–1.6) 99 123 0.9 (0.6–1.3)     
  TT 46 86 0.6 (0.3–0.9)         
  P interaction, age category and MTHFR genotype = 0.34             
Women             
  CC 89 102 1.0 — 178 206 1.0 (0.7–1.4) 60 113 0.6 (0.4–0.9) 
  CT 171 217 0.9 (0.6–1.3) 134 184 0.9 (0.6–1.2)     
  TT 71 103 0.8 (0.5–1.2)         
 Age of diagnosis/selection <65 years             
  CC 38 47 1.0 — 78 72 1.4 (0.8–2.4) 21 39 0.7 (0.3–1.4) 
  CT 72 88 1.1 (0.6–1.8) 52 81 0.9 (0.5–1.7)     
  TT 27 38 1.0 (0.5–1.9)         
 Age of diagnosis/selection 65–79 years             
  CC 51 55 1.0 — 100 134 0.8 (0.5–1.3) 39 74 0.6 (0.3–1.0) 
  CT 99 129 0.8 (0.5–1.3) 82 103 0.8 (0.5–1.4)     
  TT 44 65 0.7 (0.4–1.2)         
  P interaction, age category and MTHFR genotype = 0.86             
a

Adjusted for age, body mass index, lifetime vigorous activity, energy intake, dietary fiber, dietary calcium, and usual number of cigarettes smoked. Participants with missing data for any of these variables were excluded (11 men and 10 women).

b

MTHFR 677/1298 genotypes CT/CC, TT/AC, and TT/CC were not observed in the study population.

c

OR, odds ratio; CI, confidence interval.

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