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Table 1

Characteristics of the study population (n = 3580)

Cases (n = 1608)Controls (n = 1972)P                  a
Tumor site    
 Proximal 794 (49%)   
 Distal 775 (48%)   
 Unknown site 39 (3%)   
Age at diagnosis or selection (range, 30–79)    
 Yearsb 64.4 +/− 9.8 64.5 +/− 10.1 0.77 
Sex    
 Men 900 (56%) 1042 (53%)  
 Women 708 (44%) 930 (47%) 0.06 
Recent hormone-replacement therapy use, postmenopausal womenc    
 No 470 (77%) 551 (69%)  
 Yes 144 (23%) 243 (31%) <0.01 
Kilocaloriesb    
 Men 2773 +/− 1217 2637 +/− 1160 0.01 
 Women 2048 +/− 876 1972 +/− 831 0.07 
Folate (mcg/day)d    
 Men 387 (215) 393 (214) 0.80 
 Women 320 (177) 321 (174) 0.68 
Vitamin B12 (mcg/day)d    
 Men 6.5 (4.9) 6.3 (4.7) 0.18 
 Women 4.5 (3.4) 4.5 (3.4) 0.61 
Long-term alcohol intake (gm/day)d    
 Men 14.7 (27.0) 12.0 (24.8) 0.08 
 Women 3.7 (9.2) 3.7 (9.0) 0.43 
MTHFR 677 and 1298 genotypese    
 677 CC (wt) and 1298 AA (wt) 223 (14%) 247 (13%)  
 677 CT (het) and 1298 AA (wt) 384 (24%) 455 (23%)  
 677 TT (var) and 1298 AA (wt) 150 (9%) 227 (12%)  
 677 CC (wt) and 1298 AC (het) 358 (22%) 424 (21%)  
 677 CT (het) and 1298 AC (het) 340 (21%) 403 (20%)  
 677 TT (var) and 1298 AC (het) — —  
 677 CC (wt) and 1298 CC (var) 153 (10%) 216 (11%)  
 677 CT (het) and 1298 CC (var) — —  
 677 TT (var) and 1298 CC (var) — — 0.17 
Cases (n = 1608)Controls (n = 1972)P                  a
Tumor site    
 Proximal 794 (49%)   
 Distal 775 (48%)   
 Unknown site 39 (3%)   
Age at diagnosis or selection (range, 30–79)    
 Yearsb 64.4 +/− 9.8 64.5 +/− 10.1 0.77 
Sex    
 Men 900 (56%) 1042 (53%)  
 Women 708 (44%) 930 (47%) 0.06 
Recent hormone-replacement therapy use, postmenopausal womenc    
 No 470 (77%) 551 (69%)  
 Yes 144 (23%) 243 (31%) <0.01 
Kilocaloriesb    
 Men 2773 +/− 1217 2637 +/− 1160 0.01 
 Women 2048 +/− 876 1972 +/− 831 0.07 
Folate (mcg/day)d    
 Men 387 (215) 393 (214) 0.80 
 Women 320 (177) 321 (174) 0.68 
Vitamin B12 (mcg/day)d    
 Men 6.5 (4.9) 6.3 (4.7) 0.18 
 Women 4.5 (3.4) 4.5 (3.4) 0.61 
Long-term alcohol intake (gm/day)d    
 Men 14.7 (27.0) 12.0 (24.8) 0.08 
 Women 3.7 (9.2) 3.7 (9.0) 0.43 
MTHFR 677 and 1298 genotypese    
 677 CC (wt) and 1298 AA (wt) 223 (14%) 247 (13%)  
 677 CT (het) and 1298 AA (wt) 384 (24%) 455 (23%)  
 677 TT (var) and 1298 AA (wt) 150 (9%) 227 (12%)  
 677 CC (wt) and 1298 AC (het) 358 (22%) 424 (21%)  
 677 CT (het) and 1298 AC (het) 340 (21%) 403 (20%)  
 677 TT (var) and 1298 AC (het) — —  
 677 CC (wt) and 1298 CC (var) 153 (10%) 216 (11%)  
 677 CT (het) and 1298 CC (var) — —  
 677 TT (var) and 1298 CC (var) — — 0.17 
a

Based on χ2 or t test.

b

Mean +/− SD.

c

Hormone replacement therapy within 2 years of diagnosis/selection.

d

Median (interquartile range) for dietary intake. Long-term alcohol intake based on consumption of wine, beer, and liquor for drinkers reported 10 and 20 years ago, averaged.

e

Some genotypes of MTHFR 677 and 1298 were not observed, presumably due to complete linkage disequilibrium.

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