Joint effects of the MTHFR C677T polymorphism and folate or ethanol intake on breast cancer risk among ever users of HRT at baseline
| . | CC . | . | CT . | . | TT . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | n* . | OR (95% CI)† . | n . | OR (95% CI) . | n . | OR (95% CI) . | ||||||
| Food folate (μg/d) | ||||||||||||
| ≤214 | 69/125 | 1.00 | 54/97 | 0.88 (0.55-1.40) | 15/17 | 1.29 (0.59-2.82) | ||||||
| 215-316 | 62/130 | 0.79 (0.51-1.23) | 77/117 | 0.95 (0.61-1.46) | 11/33 | 0.49 (0.22-1.05) | ||||||
| 317-473 | 84/134 | 1.02 (0.67-1.54) | 81/93 | 1.24 (0.79-1.93) | 19/39 | 0.67 (0.35-1.28) | ||||||
| >473 | 62/115 | 0.98 (0.63-1.52) | 50/113 | 0.73 (0.46-1.17) | 17/31 | 0.68 (0.34-1.36) | ||||||
| P | 0.34‡ | |||||||||||
| Total folate (μg/d) | ||||||||||||
| ≤257 | 63/113 | 1.00 | 54/98 | 0.92 (0.57-1.48) | 6/23 | 0.33 (0.12-0.87) | ||||||
| 258-437 | 68/127 | 0.94 (0.61-1.47) | 67/93 | 1.02 (0.64-1.61) | 11/32 | 0.49 (0.22-1.07) | ||||||
| 438-678 | 74/135 | 0.86 (0.56-1.34) | 80/128 | 0.84 (0.54-1.31) | 26/31 | 1.08 (0.68-2.42) | ||||||
| >678 | 72/129 | 0.89 (0.57-1.38) | 61/101 | 0.92 (0.58-1.47) | 19/34 | 0.63 (0.32-1.24) | ||||||
| P | 0.13 | |||||||||||
| Ethanol (g/d) | ||||||||||||
| 0 | 156/284 | 1.00 | 143/236 | 0.96 (0.71-1.30) | 37/81 | 0.63 (0.40-1.00) | ||||||
| 1-10 | 71/162 | 0.83 (0.58-1.19) | 83/143 | 0.97 (0.68-1.38) | 20/30 | 1.07 (0.57-2.02) | ||||||
| >10 | 50/58 | 1.51 (0.96-2.37) | 36/41 | 1.34 (0.80-2.26) | 5/9 | 0.85 (0.27-2.67) | ||||||
| P | 0.48 | |||||||||||
| . | CC . | . | CT . | . | TT . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | n* . | OR (95% CI)† . | n . | OR (95% CI) . | n . | OR (95% CI) . | ||||||
| Food folate (μg/d) | ||||||||||||
| ≤214 | 69/125 | 1.00 | 54/97 | 0.88 (0.55-1.40) | 15/17 | 1.29 (0.59-2.82) | ||||||
| 215-316 | 62/130 | 0.79 (0.51-1.23) | 77/117 | 0.95 (0.61-1.46) | 11/33 | 0.49 (0.22-1.05) | ||||||
| 317-473 | 84/134 | 1.02 (0.67-1.54) | 81/93 | 1.24 (0.79-1.93) | 19/39 | 0.67 (0.35-1.28) | ||||||
| >473 | 62/115 | 0.98 (0.63-1.52) | 50/113 | 0.73 (0.46-1.17) | 17/31 | 0.68 (0.34-1.36) | ||||||
| P | 0.34‡ | |||||||||||
| Total folate (μg/d) | ||||||||||||
| ≤257 | 63/113 | 1.00 | 54/98 | 0.92 (0.57-1.48) | 6/23 | 0.33 (0.12-0.87) | ||||||
| 258-437 | 68/127 | 0.94 (0.61-1.47) | 67/93 | 1.02 (0.64-1.61) | 11/32 | 0.49 (0.22-1.07) | ||||||
| 438-678 | 74/135 | 0.86 (0.56-1.34) | 80/128 | 0.84 (0.54-1.31) | 26/31 | 1.08 (0.68-2.42) | ||||||
| >678 | 72/129 | 0.89 (0.57-1.38) | 61/101 | 0.92 (0.58-1.47) | 19/34 | 0.63 (0.32-1.24) | ||||||
| P | 0.13 | |||||||||||
| Ethanol (g/d) | ||||||||||||
| 0 | 156/284 | 1.00 | 143/236 | 0.96 (0.71-1.30) | 37/81 | 0.63 (0.40-1.00) | ||||||
| 1-10 | 71/162 | 0.83 (0.58-1.19) | 83/143 | 0.97 (0.68-1.38) | 20/30 | 1.07 (0.57-2.02) | ||||||
| >10 | 50/58 | 1.51 (0.96-2.37) | 36/41 | 1.34 (0.80-2.26) | 5/9 | 0.85 (0.27-2.67) | ||||||
| P | 0.48 | |||||||||||
No. cases/no. controls (15 cases and 28 controls were excluded due to unreliable dietary information).
ORs (95% CIs) adjusted for ethnicity and age at blood draw.
P value derived from a likelihood ratio test comparing a model with main effects for the MTHFR C677T genotype and the dietary variable, and a model with main effects and interaction terms (df, 6 and 4 for folate analyses and alcohol analysis, respectively).