Skip to Main Content
Table 6.

Joint effects of the MTHFR C677T polymorphism and folate or ethanol intake on breast cancer risk among ever users of HRT at baseline

CC

CT

TT

n*OR (95% CI)nOR (95% CI)nOR (95% CI)
Food folate (μg/d)       
    ≤214 69/125 1.00 54/97 0.88 (0.55-1.40) 15/17 1.29 (0.59-2.82) 
    215-316 62/130 0.79 (0.51-1.23) 77/117 0.95 (0.61-1.46) 11/33 0.49 (0.22-1.05) 
    317-473 84/134 1.02 (0.67-1.54) 81/93 1.24 (0.79-1.93) 19/39 0.67 (0.35-1.28) 
    >473 62/115 0.98 (0.63-1.52) 50/113 0.73 (0.46-1.17) 17/31 0.68 (0.34-1.36) 
    P 0.34      
Total folate (μg/d)       
    ≤257 63/113 1.00 54/98 0.92 (0.57-1.48) 6/23 0.33 (0.12-0.87) 
    258-437 68/127 0.94 (0.61-1.47) 67/93 1.02 (0.64-1.61) 11/32 0.49 (0.22-1.07) 
    438-678 74/135 0.86 (0.56-1.34) 80/128 0.84 (0.54-1.31) 26/31 1.08 (0.68-2.42) 
    >678 72/129 0.89 (0.57-1.38) 61/101 0.92 (0.58-1.47) 19/34 0.63 (0.32-1.24) 
    P 0.13      
Ethanol (g/d)       
    0 156/284 1.00 143/236 0.96 (0.71-1.30) 37/81 0.63 (0.40-1.00) 
    1-10 71/162 0.83 (0.58-1.19) 83/143 0.97 (0.68-1.38) 20/30 1.07 (0.57-2.02) 
    >10 50/58 1.51 (0.96-2.37) 36/41 1.34 (0.80-2.26) 5/9 0.85 (0.27-2.67) 
    P 0.48      
CC

CT

TT

n*OR (95% CI)nOR (95% CI)nOR (95% CI)
Food folate (μg/d)       
    ≤214 69/125 1.00 54/97 0.88 (0.55-1.40) 15/17 1.29 (0.59-2.82) 
    215-316 62/130 0.79 (0.51-1.23) 77/117 0.95 (0.61-1.46) 11/33 0.49 (0.22-1.05) 
    317-473 84/134 1.02 (0.67-1.54) 81/93 1.24 (0.79-1.93) 19/39 0.67 (0.35-1.28) 
    >473 62/115 0.98 (0.63-1.52) 50/113 0.73 (0.46-1.17) 17/31 0.68 (0.34-1.36) 
    P 0.34      
Total folate (μg/d)       
    ≤257 63/113 1.00 54/98 0.92 (0.57-1.48) 6/23 0.33 (0.12-0.87) 
    258-437 68/127 0.94 (0.61-1.47) 67/93 1.02 (0.64-1.61) 11/32 0.49 (0.22-1.07) 
    438-678 74/135 0.86 (0.56-1.34) 80/128 0.84 (0.54-1.31) 26/31 1.08 (0.68-2.42) 
    >678 72/129 0.89 (0.57-1.38) 61/101 0.92 (0.58-1.47) 19/34 0.63 (0.32-1.24) 
    P 0.13      
Ethanol (g/d)       
    0 156/284 1.00 143/236 0.96 (0.71-1.30) 37/81 0.63 (0.40-1.00) 
    1-10 71/162 0.83 (0.58-1.19) 83/143 0.97 (0.68-1.38) 20/30 1.07 (0.57-2.02) 
    >10 50/58 1.51 (0.96-2.37) 36/41 1.34 (0.80-2.26) 5/9 0.85 (0.27-2.67) 
    P 0.48      
*

No. cases/no. controls (15 cases and 28 controls were excluded due to unreliable dietary information).

ORs (95% CIs) adjusted for ethnicity and age at blood draw.

P value derived from a likelihood ratio test comparing a model with main effects for the MTHFR C677T genotype and the dietary variable, and a model with main effects and interaction terms (df, 6 and 4 for folate analyses and alcohol analysis, respectively).

Close Modal

or Create an Account

Close Modal
Close Modal