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Table 4.

Breast cancer ORs (95% CIs) for the MTHFR C677T and A1298C polymorphisms and HRT use at baseline

GenotypeNever
Past
Current*
nOR (95% CI)nOR (95% CI)nOR (95% CI)
677       
    CC 240/619 1.00 103/221 1.00 181/295 1.00 
    CT 170/418 1.00 (0.78-1.28) 81/150 1.06 (0.72-1.58) 187/282 0.95 (0.72-1.26) 
    TT 63/137 1.07 (0.75-1.54) 27/50 1.07 (0.60-1.92) 37/74 0.62 (0.39-0.98) 
    P  0.77  0.76  0.09 
1298       
    AA 294/730 1.00 141/274 1.00 250/384 1.00 
    AC 148/383 0.99 (0.78-1.26) 59/129 0.88 (0.60-1.29) 124/235 0.74 (0.56-0.99) 
    CC 31/61 1.23 (0.77-1.96) 11/18 1.21 (0.53-2.75) 31/32 1.28 (0.74-2.21) 
    P  0.61  0.85  0.46 
GenotypeNever
Past
Current*
nOR (95% CI)nOR (95% CI)nOR (95% CI)
677       
    CC 240/619 1.00 103/221 1.00 181/295 1.00 
    CT 170/418 1.00 (0.78-1.28) 81/150 1.06 (0.72-1.58) 187/282 0.95 (0.72-1.26) 
    TT 63/137 1.07 (0.75-1.54) 27/50 1.07 (0.60-1.92) 37/74 0.62 (0.39-0.98) 
    P  0.77  0.76  0.09 
1298       
    AA 294/730 1.00 141/274 1.00 250/384 1.00 
    AC 148/383 0.99 (0.78-1.26) 59/129 0.88 (0.60-1.29) 124/235 0.74 (0.56-0.99) 
    CC 31/61 1.23 (0.77-1.96) 11/18 1.21 (0.53-2.75) 31/32 1.28 (0.74-2.21) 
    P  0.61  0.85  0.46 

NOTE: Adjusted for age at blood draw and race and/or ethnicity.

*

Current: Current use of hormonal replacement therapy at baseline (100 cases and 168 controls were excluded due to missing information on HRT use).

No. cases/no. controls.

P value for a gene dosage term assigned 1, 2, and 3 for 0, 1, and 2 variant alleles, respectively.

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