Breast cancer ORs (95% CIs) for the MTHFR C677T and A1298C polymorphisms and HRT use at baseline
| Genotype . | Never . | . | Past . | . | Current* . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | n† . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | ||||||
| 677 | ||||||||||||
| CC | 240/619 | 1.00 | 103/221 | 1.00 | 181/295 | 1.00 | ||||||
| CT | 170/418 | 1.00 (0.78-1.28) | 81/150 | 1.06 (0.72-1.58) | 187/282 | 0.95 (0.72-1.26) | ||||||
| TT | 63/137 | 1.07 (0.75-1.54) | 27/50 | 1.07 (0.60-1.92) | 37/74 | 0.62 (0.39-0.98) | ||||||
| P | 0.77‡ | 0.76 | 0.09 | |||||||||
| 1298 | ||||||||||||
| AA | 294/730 | 1.00 | 141/274 | 1.00 | 250/384 | 1.00 | ||||||
| AC | 148/383 | 0.99 (0.78-1.26) | 59/129 | 0.88 (0.60-1.29) | 124/235 | 0.74 (0.56-0.99) | ||||||
| CC | 31/61 | 1.23 (0.77-1.96) | 11/18 | 1.21 (0.53-2.75) | 31/32 | 1.28 (0.74-2.21) | ||||||
| P | 0.61 | 0.85 | 0.46 | |||||||||
| Genotype . | Never . | . | Past . | . | Current* . | . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | n† . | OR (95% CI) . | n . | OR (95% CI) . | n . | OR (95% CI) . | ||||||
| 677 | ||||||||||||
| CC | 240/619 | 1.00 | 103/221 | 1.00 | 181/295 | 1.00 | ||||||
| CT | 170/418 | 1.00 (0.78-1.28) | 81/150 | 1.06 (0.72-1.58) | 187/282 | 0.95 (0.72-1.26) | ||||||
| TT | 63/137 | 1.07 (0.75-1.54) | 27/50 | 1.07 (0.60-1.92) | 37/74 | 0.62 (0.39-0.98) | ||||||
| P | 0.77‡ | 0.76 | 0.09 | |||||||||
| 1298 | ||||||||||||
| AA | 294/730 | 1.00 | 141/274 | 1.00 | 250/384 | 1.00 | ||||||
| AC | 148/383 | 0.99 (0.78-1.26) | 59/129 | 0.88 (0.60-1.29) | 124/235 | 0.74 (0.56-0.99) | ||||||
| CC | 31/61 | 1.23 (0.77-1.96) | 11/18 | 1.21 (0.53-2.75) | 31/32 | 1.28 (0.74-2.21) | ||||||
| P | 0.61 | 0.85 | 0.46 | |||||||||
NOTE: Adjusted for age at blood draw and race and/or ethnicity.
Current: Current use of hormonal replacement therapy at baseline (100 cases and 168 controls were excluded due to missing information on HRT use).
No. cases/no. controls.
P value for a gene dosage term assigned 1, 2, and 3 for 0, 1, and 2 variant alleles, respectively.