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Table 3.

Breast cancer ORs (95% CIs) by MTHFR C677T or A1298C genotype and ethnicity

Ethnicity	n*	OR	n	OR (95% CI)	n	OR (95% CI)	P^†
	C677T
	CC			CT			TT
Japanese American	135/140	1.00	140/196	0.75 (0.53-1.03)	43/74	0.60 (0.39-0.94)	0.02
White	131/178	1.00	151/176	1.11 (0.81-1.54)	38/61	0.80 (0.50-1.29)	0.65
African American	196/490	1.00	47/140	0.83 (0.57-1.20)	3/9	0.86 (0.23-3.23)	0.34
Latino	70/218	1.00	117/319	1.20 (0.85-1.70)	49/127	1.19 (0.78-1.83)	0.36
Hawaiian	41/185	1.00	24/89	1.25 (0.71-2.21)	4/12	1.40 (0.42-4.69)	0.38
	A1298C
	AA			AC			CC
Japanese American	224/271	1.00	83/126	0.81 (0.58-1.13)	11/13	1.13 (0.49-2.58)	0.44
White	160/211	1.00	118/166	0.91 (0.66-1.25)	42/38	1.39 (0.85-2.28)	0.48
African American	171/433	1.00	68/187	0.92 (0.67-1.29)	7/19	0.96 (0.40-2.34)	0.68
Latino	146/423	1.00	77/212	1.07 (0.78-1.48)	13/29	1.24 (0.63-2.47)	0.50
Hawaiian	40/155	1.00	25/110	0.85 (0.48-1.49)	4/21	0.73 (0.23-2.26)	0.46

Ethnicity	n*	OR	n	OR (95% CI)	n	OR (95% CI)	P^†
	C677T
	CC			CT			TT
Japanese American	135/140	1.00	140/196	0.75 (0.53-1.03)	43/74	0.60 (0.39-0.94)	0.02
White	131/178	1.00	151/176	1.11 (0.81-1.54)	38/61	0.80 (0.50-1.29)	0.65
African American	196/490	1.00	47/140	0.83 (0.57-1.20)	3/9	0.86 (0.23-3.23)	0.34
Latino	70/218	1.00	117/319	1.20 (0.85-1.70)	49/127	1.19 (0.78-1.83)	0.36
Hawaiian	41/185	1.00	24/89	1.25 (0.71-2.21)	4/12	1.40 (0.42-4.69)	0.38
	A1298C
	AA			AC			CC
Japanese American	224/271	1.00	83/126	0.81 (0.58-1.13)	11/13	1.13 (0.49-2.58)	0.44
White	160/211	1.00	118/166	0.91 (0.66-1.25)	42/38	1.39 (0.85-2.28)	0.48
African American	171/433	1.00	68/187	0.92 (0.67-1.29)	7/19	0.96 (0.40-2.34)	0.68
Latino	146/423	1.00	77/212	1.07 (0.78-1.48)	13/29	1.24 (0.63-2.47)	0.50
Hawaiian	40/155	1.00	25/110	0.85 (0.48-1.49)	4/21	0.73 (0.23-2.26)	0.46

NOTE: Adjusted for age at blood draw.

No. cases/no. controls.

P value for gene dosage term assigned 1, 2, and 3 for 0, 1, and 2 variant alleles, respectively.