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Table 1

Relationship of alcohol intake and risk of colorectal cancer according to ADH3 genotype

OverallADH3 GenotypeP, trend
ADH31-1ADH31-2ADH32-2
RRa (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]
Overall  1.0 (referent) [86, 426] 0.92 (0.67–1.27) [96, 513] 0.83 (0.53–1.31) [29, 174] 0.40 
Alcohol consumption (drinks/week)      
 ≤1 1.0 (referent) [61, 397] 1.0 (referent) [28, 167] 1.09 (0.62–1.91) [28, 162] 0.44 (0.16–1.20) [5, 68] 0.20 
 2–4 1.51 (1.05–2.17) [84, 369] 1.54 (0.88–2.71) [31, 128] 1.42 (0.84–2.40) [41, 184] 1.38 (0.66–2.90) [12, 57] 0.68 
 ≥5 1.25 (0.85–1.84) [66, 338] 1.31 (0.73–2.35) [27, 127] 1.00 (0.56–1.78) [27, 163] 1.63 (0.77–3.45) [12, 48] 0.94 
P, trend 0.25 0.59 0.81 0.04  
OverallADH3 GenotypeP, trend
ADH31-1ADH31-2ADH32-2
RRa (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]RR (95% CI) [No. case, No. control]
Overall  1.0 (referent) [86, 426] 0.92 (0.67–1.27) [96, 513] 0.83 (0.53–1.31) [29, 174] 0.40 
Alcohol consumption (drinks/week)      
 ≤1 1.0 (referent) [61, 397] 1.0 (referent) [28, 167] 1.09 (0.62–1.91) [28, 162] 0.44 (0.16–1.20) [5, 68] 0.20 
 2–4 1.51 (1.05–2.17) [84, 369] 1.54 (0.88–2.71) [31, 128] 1.42 (0.84–2.40) [41, 184] 1.38 (0.66–2.90) [12, 57] 0.68 
 ≥5 1.25 (0.85–1.84) [66, 338] 1.31 (0.73–2.35) [27, 127] 1.00 (0.56–1.78) [27, 163] 1.63 (0.77–3.45) [12, 48] 0.94 
P, trend 0.25 0.59 0.81 0.04  
a

RR adjusted for age, smoking status, use of aspirin, and multivitamins.

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