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Table 4.

Univariate Cox regression analysis of potential prognostic factors for time to metastases and DSS

VariableTime to metastases, hazard ratio (95% CI)PDSS, hazard ratio (95% CI)P
Karnofsky performance status     
    ≥90% versus <90% 0.6 (0.1-2.6) 0.50 0.4 (0.1-1.7) 0.19 
Sex     
    Female vs. male 0.9 (0.4-1.9) 0.82 0.7 (0.3-1.8) 0.49 
Largest tumor diameter     
    ≤14 mm vs. >14 mm 2.3 (0.9-5.8) 0.07 3.2 (0.9-11.2) 0.06 
Ciliary body involvement 1 (0.5-2.2) 0.96 0.6 (0.2-1.8) 0.40 
Extraocular growth 0.8 (0.2-3.5) 0.81 1.2 (0.3-5.3) 0.79 
PCR6.3 (2.6-15.5) <0.001 10.9 (4-29) <0.001 
Tyrosinase 6.8 (2.3-20.5) 0.001 8.9 (2.8-28) <0.001 
MelanA/MART1 5.2 (1.7-15.4) 0.003 10.3 (3.1-34) <0.001 
VariableTime to metastases, hazard ratio (95% CI)PDSS, hazard ratio (95% CI)P
Karnofsky performance status     
    ≥90% versus <90% 0.6 (0.1-2.6) 0.50 0.4 (0.1-1.7) 0.19 
Sex     
    Female vs. male 0.9 (0.4-1.9) 0.82 0.7 (0.3-1.8) 0.49 
Largest tumor diameter     
    ≤14 mm vs. >14 mm 2.3 (0.9-5.8) 0.07 3.2 (0.9-11.2) 0.06 
Ciliary body involvement 1 (0.5-2.2) 0.96 0.6 (0.2-1.8) 0.40 
Extraocular growth 0.8 (0.2-3.5) 0.81 1.2 (0.3-5.3) 0.79 
PCR6.3 (2.6-15.5) <0.001 10.9 (4-29) <0.001 
Tyrosinase 6.8 (2.3-20.5) 0.001 8.9 (2.8-28) <0.001 
MelanA/MART1 5.2 (1.7-15.4) 0.003 10.3 (3.1-34) <0.001 

Abbreviation: 95% CI, 95% confidence interval.

*

Tyrosinase or MelanA/MART1.

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