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Table 2.

Top 50 down-regulated genes

Accession no.Unigene IDSymbolDescriptionFold of change
AA194983 Hs.81791 TNFRSF11B Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) −95.28 
AA486444 Hs.505687 PYM Within bgcn homologue (Drosophila−30.49 
AA598794 Hs.410037 CTGF Connective tissue growth factor −27.45 
N35316 Hs.153952 NT5E 5′-nucleotidase, ecto (CD73) −27.19 
AA629591 Hs.35052 TEGT Testis enhanced gene transcript (BAX inhibitor 1) −26.86 
AA917374 Hs.104839 TIMP2 Tissue inhibitor of metalloproteinase 2 −25.98 
AI262978 Hs.435974 MTHFD1 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase −20.70 
H13623 Hs.26139 EPS8 Epidermal growth factor receptor pathway substrate 8 −20.60 
H23235 Hs.74615 PDGFRA Platelet-derived growth factor receptor, α-polypeptide −20.51 
H88540 Hs.187199 MALAT1 Metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) −16.50 
AA136710 Hs.268849 GLO1 Glyoxalase I −16.36 
AA495936 Hs.389700 MGST1 Microsomal glutathione S-transferase 1 −15.68 
AA487429 Hs.352018 TAP1 Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP) −14.88 
R09561 Hs.527653 DAF Decay accelerating factor for complement (CD55, Cromer blood group system) −13.88 
AA598817 Hs.30743 PRAME Preferentially expressed antigen in melanoma −13.75 
T62048 Hs.458355 C1S Complement component 1, s subcomponent −13.35 
AA670438 Hs.518731 UCHL1 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) −13.12 
AA130042 Hs.438970 TBL1XR1 Transducin (β)-like 1X-linked receptor 1 −12.99 
N66644 Hs.132513 HSD17B12 Hydroxysteroid (17-β) dehydrogenase 12 −12.60 
AA464246 Hs.534125 HLA-C MHC, class I, C −12.07 
H11003 Hs.511899 EDN1 Endothelin 1 −12.02 
AA937895 Hs.495605 CD99 CD99 antigen −11.79 
AA043133 Hs.75231 SLC16A1 Solute carrier family 16 (monocarboxylic acid transporters), member 1 −11.70 
AA181300 Hs.180062 PSMB8 Proteasome (prosome, macropain) subunit, β type, 8 (large multifunctional protease 7) −11.59 
N21573 Hs.514685 TWSG1 Twisted gastrulation homologue 1 (Drosophila−11.10 
H99676 Hs.474053 COL6A1 Collagen, type VI, α1 −10.72 
H15574 Hs.127826 EPOR Erythropoietin receptor −10.53 
AA447561 Hs.90691 NPM3 Nucleophosmin/nucleoplasmin, 3 −10.53 
AA630771 Hs.413812 RAC1 Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) −10.48 
W73874 Hs.418123 CTSL Cathepsin L −10.42 
AA878257 Hs.173894 CSF1 Colony-stimulating factor 1 (macrophage) −10.21 
R76394 Hs.25338 PRSS23 Protease, serine, 23 −10.13 
AA865464 Hs.521903 LY6E Lymphocyte antigen 6 complex, locus E −10.11 
AA504482 Hs.185597 SPG7 Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) −9.82 
AA056232 Hs.75652 GSTM5 Glutathione S-transferase M5 −9.80 
AA486570 Hs.348387 GSTM4 Glutathione S-transferase M4 −9.62 
N52911 Hs.436687 SET SET translocation (myeloid leukemia-associated) −9.46 
AI356709 Hs.332197 D2S448 Melanoma associated gene −9.45 
AI084613 Hs.56186 EGFL3 EGF-like-domain, multiple 3 −9.36 
AA424956 Hs.151777 EIF2S1 Eukaryotic translation initiation factor 2, subunit 1 α, 35 kDa −9.34 
R25377 Hs.484813 DEK DEK oncogene (DNA binding) −9.22 
AA453749 Hs.506748 HDGF Hepatoma-derived growth factor (high-mobility group protein 1-like) −8.98 
AA487486 Hs.523852 CCND1 Cyclin D1 (PRAD1: parathyroid adenomatosis 1) −8.93 
AA485353 Hs.514535 LGALS3BP Lectin, galactoside-binding, soluble, 3 binding protein −8.83 
AA504348 Hs.156346 TOP2A Topoisomerase (DNA) II α 170 kDa −8.80 
AA479090 Hs.295137 AMFR Autocrine motility factor receptor −8.69 
AA464849 Hs.434367 TXNRD1 Thioredoxin reductase 1 −8.57 
AA676466 Hs.160786 ASS Argininosuccinate synthetase −8.54 
AA410636 Hs.445403 IARS Isoleucine-tRNA synthetase −8.51 
R38933 Hs.491582 PLAT Plasminogen activator, tissue −8.32 
Accession no.Unigene IDSymbolDescriptionFold of change
AA194983 Hs.81791 TNFRSF11B Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) −95.28 
AA486444 Hs.505687 PYM Within bgcn homologue (Drosophila−30.49 
AA598794 Hs.410037 CTGF Connective tissue growth factor −27.45 
N35316 Hs.153952 NT5E 5′-nucleotidase, ecto (CD73) −27.19 
AA629591 Hs.35052 TEGT Testis enhanced gene transcript (BAX inhibitor 1) −26.86 
AA917374 Hs.104839 TIMP2 Tissue inhibitor of metalloproteinase 2 −25.98 
AI262978 Hs.435974 MTHFD1 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase −20.70 
H13623 Hs.26139 EPS8 Epidermal growth factor receptor pathway substrate 8 −20.60 
H23235 Hs.74615 PDGFRA Platelet-derived growth factor receptor, α-polypeptide −20.51 
H88540 Hs.187199 MALAT1 Metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) −16.50 
AA136710 Hs.268849 GLO1 Glyoxalase I −16.36 
AA495936 Hs.389700 MGST1 Microsomal glutathione S-transferase 1 −15.68 
AA487429 Hs.352018 TAP1 Transporter 1, ATP-binding cassette, subfamily B (MDR/TAP) −14.88 
R09561 Hs.527653 DAF Decay accelerating factor for complement (CD55, Cromer blood group system) −13.88 
AA598817 Hs.30743 PRAME Preferentially expressed antigen in melanoma −13.75 
T62048 Hs.458355 C1S Complement component 1, s subcomponent −13.35 
AA670438 Hs.518731 UCHL1 Ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) −13.12 
AA130042 Hs.438970 TBL1XR1 Transducin (β)-like 1X-linked receptor 1 −12.99 
N66644 Hs.132513 HSD17B12 Hydroxysteroid (17-β) dehydrogenase 12 −12.60 
AA464246 Hs.534125 HLA-C MHC, class I, C −12.07 
H11003 Hs.511899 EDN1 Endothelin 1 −12.02 
AA937895 Hs.495605 CD99 CD99 antigen −11.79 
AA043133 Hs.75231 SLC16A1 Solute carrier family 16 (monocarboxylic acid transporters), member 1 −11.70 
AA181300 Hs.180062 PSMB8 Proteasome (prosome, macropain) subunit, β type, 8 (large multifunctional protease 7) −11.59 
N21573 Hs.514685 TWSG1 Twisted gastrulation homologue 1 (Drosophila−11.10 
H99676 Hs.474053 COL6A1 Collagen, type VI, α1 −10.72 
H15574 Hs.127826 EPOR Erythropoietin receptor −10.53 
AA447561 Hs.90691 NPM3 Nucleophosmin/nucleoplasmin, 3 −10.53 
AA630771 Hs.413812 RAC1 Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) −10.48 
W73874 Hs.418123 CTSL Cathepsin L −10.42 
AA878257 Hs.173894 CSF1 Colony-stimulating factor 1 (macrophage) −10.21 
R76394 Hs.25338 PRSS23 Protease, serine, 23 −10.13 
AA865464 Hs.521903 LY6E Lymphocyte antigen 6 complex, locus E −10.11 
AA504482 Hs.185597 SPG7 Spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) −9.82 
AA056232 Hs.75652 GSTM5 Glutathione S-transferase M5 −9.80 
AA486570 Hs.348387 GSTM4 Glutathione S-transferase M4 −9.62 
N52911 Hs.436687 SET SET translocation (myeloid leukemia-associated) −9.46 
AI356709 Hs.332197 D2S448 Melanoma associated gene −9.45 
AI084613 Hs.56186 EGFL3 EGF-like-domain, multiple 3 −9.36 
AA424956 Hs.151777 EIF2S1 Eukaryotic translation initiation factor 2, subunit 1 α, 35 kDa −9.34 
R25377 Hs.484813 DEK DEK oncogene (DNA binding) −9.22 
AA453749 Hs.506748 HDGF Hepatoma-derived growth factor (high-mobility group protein 1-like) −8.98 
AA487486 Hs.523852 CCND1 Cyclin D1 (PRAD1: parathyroid adenomatosis 1) −8.93 
AA485353 Hs.514535 LGALS3BP Lectin, galactoside-binding, soluble, 3 binding protein −8.83 
AA504348 Hs.156346 TOP2A Topoisomerase (DNA) II α 170 kDa −8.80 
AA479090 Hs.295137 AMFR Autocrine motility factor receptor −8.69 
AA464849 Hs.434367 TXNRD1 Thioredoxin reductase 1 −8.57 
AA676466 Hs.160786 ASS Argininosuccinate synthetase −8.54 
AA410636 Hs.445403 IARS Isoleucine-tRNA synthetase −8.51 
R38933 Hs.491582 PLAT Plasminogen activator, tissue −8.32 
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