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Table 1.

Properties of IT-101 preparations used

Batch no.Studies*Mw of the parent polymer (kDa)Mw/MnCPT loading (wt %)%Free CPTParticle size (nm)
SD 85 1.48 5.03 1.3 78 
EF1-7 82 1.52 7.36 0.26 54 
Batch no.Studies*Mw of the parent polymer (kDa)Mw/MnCPT loading (wt %)%Free CPTParticle size (nm)
SD 85 1.48 5.03 1.3 78 
EF1-7 82 1.52 7.36 0.26 54 
*

SD, schedule and dose dependence of the antitumor activity in mice bearing LS174T xenografts; EF1-7, antitumor efficacy in seven different mouse xenograft models.

Polymer polydispersity determined by light scattering techniques.

Mean particle size of the conjugate determined in water by dynamic light scattering using a ZetaPals instrument (Brookhaven Instruments, Holtsville, NY).

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