BRCA1 expression and relationship with clinicopathologic variables in CRC
| . | BRCA1 expression (%) . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|
| . | n . | Negative (<5%) . | Positive (>5%) . | P . | ||||
| pT category | ||||||||
| pT1 | 24 | 0 (0) | 24 (100) | 0.13 | ||||
| pT2 | 61 | 6 (10) | 55 (90) | |||||
| pT3 | 212 | 31 (15) | 181 (85) | |||||
| pT4 | 25 | 5 (20) | 20 (80) | |||||
| pN category | ||||||||
| pN0 | 211 | 26 (12) | 185 (88) | 0.75 | ||||
| pN1 | 69 | 10 (15) | 59 (85) | |||||
| pN2 | 42 | 7 (17) | 35 (83) | |||||
| Stage | ||||||||
| Stage I | 72 | 6 (8) | 66 (92) | 0.6 | ||||
| Stage II | 137 | 20 (15) | 117 (85) | |||||
| Stage III/IV* | 113 | 16 (14) | 97 (86) | |||||
| Grading | ||||||||
| G1†/G2 | 245 | 30 (12) | 215 (88) | 0.49 | ||||
| G3/G4‡ | 77 | 12 (16) | 65 (84) | |||||
| Blood vessel invasion | ||||||||
| Negative | 296 | 39 (13) | 257 (87) | 0.92 | ||||
| Intramural | 11 | 1 (9) | 10 (91) | |||||
| Extramural | 15 | 2 (13) | 13 (87) | |||||
| Lymphatic vessel invasion | ||||||||
| Negative | 233 | 33 (14) | 200 (86) | 0.33 | ||||
| Positive | 89 | 9 (10) | 80 (90) | |||||
| Proliferative activity (Ki67) | ||||||||
| Low | 160 | 19 (12) | 141 (88) | 0.54 | ||||
| High | 162 | 23 (14) | 139 (86) | |||||
| . | BRCA1 expression (%) . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|
| . | n . | Negative (<5%) . | Positive (>5%) . | P . | ||||
| pT category | ||||||||
| pT1 | 24 | 0 (0) | 24 (100) | 0.13 | ||||
| pT2 | 61 | 6 (10) | 55 (90) | |||||
| pT3 | 212 | 31 (15) | 181 (85) | |||||
| pT4 | 25 | 5 (20) | 20 (80) | |||||
| pN category | ||||||||
| pN0 | 211 | 26 (12) | 185 (88) | 0.75 | ||||
| pN1 | 69 | 10 (15) | 59 (85) | |||||
| pN2 | 42 | 7 (17) | 35 (83) | |||||
| Stage | ||||||||
| Stage I | 72 | 6 (8) | 66 (92) | 0.6 | ||||
| Stage II | 137 | 20 (15) | 117 (85) | |||||
| Stage III/IV* | 113 | 16 (14) | 97 (86) | |||||
| Grading | ||||||||
| G1†/G2 | 245 | 30 (12) | 215 (88) | 0.49 | ||||
| G3/G4‡ | 77 | 12 (16) | 65 (84) | |||||
| Blood vessel invasion | ||||||||
| Negative | 296 | 39 (13) | 257 (87) | 0.92 | ||||
| Intramural | 11 | 1 (9) | 10 (91) | |||||
| Extramural | 15 | 2 (13) | 13 (87) | |||||
| Lymphatic vessel invasion | ||||||||
| Negative | 233 | 33 (14) | 200 (86) | 0.33 | ||||
| Positive | 89 | 9 (10) | 80 (90) | |||||
| Proliferative activity (Ki67) | ||||||||
| Low | 160 | 19 (12) | 141 (88) | 0.54 | ||||
| High | 162 | 23 (14) | 139 (86) | |||||