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Table 1.

Nucleotide alterations within the coding exons of PIK3CA identified in 38 HNSCC specimens

CasesExonNucleotideAmino acidPresent in normal tissueTumor site (n)
Detroit 562 20 A3140G H1047R NA Pharynx (1) 
102T G1624A E542K No Oropharynx (1) 
109T G1633A E545K No Hypopharynx (1) 
182T A1028G Y343C No Tongue (1) 
80T C1143G P381P Yes Tongue (1) 
6 cases A1173G I391M Yes Pharynx (2) oral (2) 
     Larynx(1) neck (1) 
CasesExonNucleotideAmino acidPresent in normal tissueTumor site (n)
Detroit 562 20 A3140G H1047R NA Pharynx (1) 
102T G1624A E542K No Oropharynx (1) 
109T G1633A E545K No Hypopharynx (1) 
182T A1028G Y343C No Tongue (1) 
80T C1143G P381P Yes Tongue (1) 
6 cases A1173G I391M Yes Pharynx (2) oral (2) 
     Larynx(1) neck (1) 

NOTE: The nucleotide alterations are described according to the cDNA sequence with Genbank accession no. NM_006218.

Abbreviation: NA, not available.

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