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Table 4

Characteristics of responders to gefitinib and mutations in the EGFR gene

Case nos.HistologyTissueSex/AgeSmokingExon 18Exon 19Exon 21
SQC Metastatic brain tumor F/54 Never Wild-type Del (Hm) 2,235-2,249 Wild-type 
ADC Lung tumor F/48 Never Wild-type Del (Ht) 2,235-2,249 Wild-type 
BAC Lung tumor M/74 Yes Wild-type Del (Ht) 2,236-2,250 Wild-type 
BAC Lung tumor M/67 Yes Wild-type Del (Ht) 2,235-2,249 Wild-type 
ADC Lung tumor M/78 Never Wild-type Del (Ht) 2,236-2,253, substitution of T for C at 2,236 Wild-type 
ADC Lung tumor F/54 Never Wild-type Wild-type Substitution of G for T at 2,573 (Ht) 
SQC Lung tumor M/80 Yes Wild-type Wild-type Wild-type 
ADC Lung tumor M/53 Yes Wild-type Wild-type Wild-type 
Case nos.HistologyTissueSex/AgeSmokingExon 18Exon 19Exon 21
SQC Metastatic brain tumor F/54 Never Wild-type Del (Hm) 2,235-2,249 Wild-type 
ADC Lung tumor F/48 Never Wild-type Del (Ht) 2,235-2,249 Wild-type 
BAC Lung tumor M/74 Yes Wild-type Del (Ht) 2,236-2,250 Wild-type 
BAC Lung tumor M/67 Yes Wild-type Del (Ht) 2,235-2,249 Wild-type 
ADC Lung tumor M/78 Never Wild-type Del (Ht) 2,236-2,253, substitution of T for C at 2,236 Wild-type 
ADC Lung tumor F/54 Never Wild-type Wild-type Substitution of G for T at 2,573 (Ht) 
SQC Lung tumor M/80 Yes Wild-type Wild-type Wild-type 
ADC Lung tumor M/53 Yes Wild-type Wild-type Wild-type 

Abbreviations: Hm, homozygous; Ht, heterozygous.

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