Characteristics of responders to gefitinib and mutations in the EGFR gene
| Case nos. . | Histology . | Tissue . | Sex/Age . | Smoking . | Exon 18 . | Exon 19 . | Exon 21 . |
|---|---|---|---|---|---|---|---|
| 1 | SQC | Metastatic brain tumor | F/54 | Never | Wild-type | Del (Hm) 2,235-2,249 | Wild-type |
| 2 | ADC | Lung tumor | F/48 | Never | Wild-type | Del (Ht) 2,235-2,249 | Wild-type |
| 3 | BAC | Lung tumor | M/74 | Yes | Wild-type | Del (Ht) 2,236-2,250 | Wild-type |
| 4 | BAC | Lung tumor | M/67 | Yes | Wild-type | Del (Ht) 2,235-2,249 | Wild-type |
| 5 | ADC | Lung tumor | M/78 | Never | Wild-type | Del (Ht) 2,236-2,253, substitution of T for C at 2,236 | Wild-type |
| 6 | ADC | Lung tumor | F/54 | Never | Wild-type | Wild-type | Substitution of G for T at 2,573 (Ht) |
| 7 | SQC | Lung tumor | M/80 | Yes | Wild-type | Wild-type | Wild-type |
| 8 | ADC | Lung tumor | M/53 | Yes | Wild-type | Wild-type | Wild-type |
| Case nos. . | Histology . | Tissue . | Sex/Age . | Smoking . | Exon 18 . | Exon 19 . | Exon 21 . |
|---|---|---|---|---|---|---|---|
| 1 | SQC | Metastatic brain tumor | F/54 | Never | Wild-type | Del (Hm) 2,235-2,249 | Wild-type |
| 2 | ADC | Lung tumor | F/48 | Never | Wild-type | Del (Ht) 2,235-2,249 | Wild-type |
| 3 | BAC | Lung tumor | M/74 | Yes | Wild-type | Del (Ht) 2,236-2,250 | Wild-type |
| 4 | BAC | Lung tumor | M/67 | Yes | Wild-type | Del (Ht) 2,235-2,249 | Wild-type |
| 5 | ADC | Lung tumor | M/78 | Never | Wild-type | Del (Ht) 2,236-2,253, substitution of T for C at 2,236 | Wild-type |
| 6 | ADC | Lung tumor | F/54 | Never | Wild-type | Wild-type | Substitution of G for T at 2,573 (Ht) |
| 7 | SQC | Lung tumor | M/80 | Yes | Wild-type | Wild-type | Wild-type |
| 8 | ADC | Lung tumor | M/53 | Yes | Wild-type | Wild-type | Wild-type |
Abbreviations: Hm, homozygous; Ht, heterozygous.