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Table 3

Comparison of the response rate by possible predictor of response (χ2 test)

Number of responders/total numberResponse rate (%)Significance
Age (y)    
    ≤65 14/40 35.0  
    >65 6/40 15.0 P = 0.039 
Sex    
    Male 12/61 19.7  
    Female 8/19 42.1 P = 0.049 
Smoking history    
    Smoker 10/63 15.9  
    Never-smoked 10/17 58.8 P < 0.001 
Histology    
    Non-adenocarcinoma 4/41 9.8  
    Adenocarcinoma 16/39 41.0 P = 0.001 
EGFR staining intensity    
    1-2 1/12 8.3  
    3-4 5/18 27.8 P = 0.192 
Prior chemotherapy    
    Taxanes 3/20 15.0  
    Gemcitabine 4/13 30.8  
    Taxanes and gemcitabine 10/41 24.4 P = 0.546 
Courses of prior chemotherapy    
    ≤1 10/36 27.8  
    ≥2 10/44 22.7 P = 0.604 
Acneiform skin eruption    
    =0 6/32 18.8  
    ≥1 13/37 35.1 P = 0.129 
Symptomatic improvement    
    No 1/48 2.1  
    Yes 17/19 89.5 P < 0.001 
Number of responders/total numberResponse rate (%)Significance
Age (y)    
    ≤65 14/40 35.0  
    >65 6/40 15.0 P = 0.039 
Sex    
    Male 12/61 19.7  
    Female 8/19 42.1 P = 0.049 
Smoking history    
    Smoker 10/63 15.9  
    Never-smoked 10/17 58.8 P < 0.001 
Histology    
    Non-adenocarcinoma 4/41 9.8  
    Adenocarcinoma 16/39 41.0 P = 0.001 
EGFR staining intensity    
    1-2 1/12 8.3  
    3-4 5/18 27.8 P = 0.192 
Prior chemotherapy    
    Taxanes 3/20 15.0  
    Gemcitabine 4/13 30.8  
    Taxanes and gemcitabine 10/41 24.4 P = 0.546 
Courses of prior chemotherapy    
    ≤1 10/36 27.8  
    ≥2 10/44 22.7 P = 0.604 
Acneiform skin eruption    
    =0 6/32 18.8  
    ≥1 13/37 35.1 P = 0.129 
Symptomatic improvement    
    No 1/48 2.1  
    Yes 17/19 89.5 P < 0.001 

Abbreviations: SQC, squamous cell carcinoma; ADC, adenocarcinoma; BAC, bronchiolo-alveolar cell carcinoma.

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