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Table 2.

Mean and range of phagocytosis in MDM

SubpopulationActivation conditionND PB (%)EOC PB (%)EOC ascites (%)*
CD14+ M-CSF alone 75.8 (58.0-85.0) 13.7 (0-57.0) 6.1 (0-19.0) 
 LPS 77.2 (67.0-85.0) 5.8 (0-11.9) 6.4 (0-25.5) 
 LPS + IFN-γ 74.9 (60.5-83.0) 3.2 (0-15.9) 4.4 (0-17.6) 
CD14bright CD16HLA-DR M-CSF alone 75.9 (57.0-83.5) 7.3 (0-16.0) 1.5 (0-6.0) 
 LPS 68.3 (64.0-75.0) 11.9 (0-29.5) 1.8 (0-7.0) 
 LPS + IFN-γ 68.8 (63.5-73.5) 13.6 (0-41.5) 4.6 (0-12.5) 
SubpopulationActivation conditionND PB (%)EOC PB (%)EOC ascites (%)*
CD14+ M-CSF alone 75.8 (58.0-85.0) 13.7 (0-57.0) 6.1 (0-19.0) 
 LPS 77.2 (67.0-85.0) 5.8 (0-11.9) 6.4 (0-25.5) 
 LPS + IFN-γ 74.9 (60.5-83.0) 3.2 (0-15.9) 4.4 (0-17.6) 
CD14bright CD16HLA-DR M-CSF alone 75.9 (57.0-83.5) 7.3 (0-16.0) 1.5 (0-6.0) 
 LPS 68.3 (64.0-75.0) 11.9 (0-29.5) 1.8 (0-7.0) 
 LPS + IFN-γ 68.8 (63.5-73.5) 13.6 (0-41.5) 4.6 (0-12.5) 
*

There were no significant differences between epithelial ovarian cancer peripheral blood and epithelial ovarian cancer ascites.

P ≤ 0.0015 for normal donor peripheral blood versus epithelial ovarian cancer peripheral blood, and for normal donor peripheral blood versus epithelial ovarian cancer ascites for each MDM type (CD14+ and CD14brightCD16HLA-DR+) and for each activation condition (M-CSF alone, LPS, and LPS + IFNγ).

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