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Table 1.

Molecular and biochemical features of breast cancer cell lines used in the study

MCF-7MBA-MD-157Hs578TMBA-MD-436HCC 1937UACC 3199 (*)
Tumor type* Human breast adenocarcinoma Medullary carcinoma Invasive ductal carcinoma Human breast adenocarcinoma Human breast carcinoma Ductal carcinoma 
Molecular subtypes Luminal Mesenchymal Mesenchymal Basal Basal  
TP53 status Wild-type Mutant Mutant Mutant Mutant  
ER − − − − − 
Brca1 (allelic lost/mutation status)§ Loss/wt Loss/ wt Loss/wt Loss/mutated Loss/mutated Loss/methylated 
Effects after 17-AAG treatment       
    IC50 (μmol/L) 0.032 ± 0.0092 0.00148 0.057 ± 0.021 0.059 ± 0.017 0.014 ± 0.006 0.013 ± 0.006 
    Cell cycle effect G2-M arrest G2-M arrest G2-M arrest G2-M arrest G2-M arrest G2-M arrest 
    SA-β-galactosidase staining None None None None None None 
    Mitotic entrance Low None Low High High High 
    Predominant cell death Apoptosis Apoptosis Apoptosis Mitotic catastrophe Mitotic catastrophe Mitotic catastrophe 
MCF-7MBA-MD-157Hs578TMBA-MD-436HCC 1937UACC 3199 (*)
Tumor type* Human breast adenocarcinoma Medullary carcinoma Invasive ductal carcinoma Human breast adenocarcinoma Human breast carcinoma Ductal carcinoma 
Molecular subtypes Luminal Mesenchymal Mesenchymal Basal Basal  
TP53 status Wild-type Mutant Mutant Mutant Mutant  
ER − − − − − 
Brca1 (allelic lost/mutation status)§ Loss/wt Loss/ wt Loss/wt Loss/mutated Loss/mutated Loss/methylated 
Effects after 17-AAG treatment       
    IC50 (μmol/L) 0.032 ± 0.0092 0.00148 0.057 ± 0.021 0.059 ± 0.017 0.014 ± 0.006 0.013 ± 0.006 
    Cell cycle effect G2-M arrest G2-M arrest G2-M arrest G2-M arrest G2-M arrest G2-M arrest 
    SA-β-galactosidase staining None None None None None None 
    Mitotic entrance Low None Low High High High 
    Predominant cell death Apoptosis Apoptosis Apoptosis Mitotic catastrophe Mitotic catastrophe Mitotic catastrophe 
*

Data derived from the American Type Culture Collection.

From ref. 29.

From ref. 30.

§

From ref. 31.

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