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Table 1.

In vivo applications of DNAzymes in animal models of cancer

mRNA targetAnimalXenograftDelivery modeDose regimenAnticancer activityReferences
VEGFR-2 Mouse MDA-MB-435 Intratumoral Four injections of 30 μL, each of 2.9 μg of DNAzyme and 1.092 nmol his-lys polymer 75% reduction in tumor size, cell death in tumor periphery, reduction in blood vessel density (44) 
Egr-1 Mouse MCF-7 Intratumoral Twice a week, injections of 20 μL, each of 20 μg of DNAzyme and 1 μL Fugene-6 80% reduction in tumor size, reduction in blood vessel density (45) 
c-Jun Mouse B16 Comixed with cell inoculation Commencement of experiment, 750 μg of Dz comixed with 2.5 μL Fugene-6 reagent injected s.c. 60% reduction in tumor size, reduction in blood vessel density (46) 
Egr-1 Mouse MDA-MB-231 Intratumoral When tumors were palpable, single injection of 10 μL, of 10 μg of free DNAzyme 67% reduction in tumor size (47) 
c-Jun Mouse T79 Comixed with cell inoculation Commencement of experiment, 50 μg of Dz comixed with 2.5 μL Fugene-6 reagent injected s.c. 90% reduction in tumor size (48) 
mRNA targetAnimalXenograftDelivery modeDose regimenAnticancer activityReferences
VEGFR-2 Mouse MDA-MB-435 Intratumoral Four injections of 30 μL, each of 2.9 μg of DNAzyme and 1.092 nmol his-lys polymer 75% reduction in tumor size, cell death in tumor periphery, reduction in blood vessel density (44) 
Egr-1 Mouse MCF-7 Intratumoral Twice a week, injections of 20 μL, each of 20 μg of DNAzyme and 1 μL Fugene-6 80% reduction in tumor size, reduction in blood vessel density (45) 
c-Jun Mouse B16 Comixed with cell inoculation Commencement of experiment, 750 μg of Dz comixed with 2.5 μL Fugene-6 reagent injected s.c. 60% reduction in tumor size, reduction in blood vessel density (46) 
Egr-1 Mouse MDA-MB-231 Intratumoral When tumors were palpable, single injection of 10 μL, of 10 μg of free DNAzyme 67% reduction in tumor size (47) 
c-Jun Mouse T79 Comixed with cell inoculation Commencement of experiment, 50 μg of Dz comixed with 2.5 μL Fugene-6 reagent injected s.c. 90% reduction in tumor size (48) 
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