Skip to Main Content
Table 3.

Effect of systemic administration of AEE788 on normal lung and on tumor and tumor-associated endothelial cell proliferation and apoptosis for NCI-H441 and PC14-PE6 tumors

GroupAdjacent normal lung
Tumor cells
Tumor-associated endothelial cells
% Ki67% TUNEL% Ki67% TUNELCD31% Ki67% TUNEL
NCI-H441        
Vehicle 0.1 ± 0.3 0.1 ± 0.3 48.8 ± 4.5 0.6 ± 0.6 45 ± 4 8.2 ± 2.3 0.4 ± 1.0 
AEE788 0.1 ± 0.2 0.1 ± 0.3 9.4 ± 4.4* 17.7 ± 2.0* 9 ± 2* 1.8 ± 2.7* 21.1 ± 6.8* 
PC14-PE6        
Vehicle 0.3 ± 0.4 0.1 ± 0.3 50.0 ± 12.2 0.6 ± 0.3 36 ± 6 6.5 ± 1.9 0.5 ± 1.1 
AEE788 0.1 ± 0.3 0.1 ± 0.3 46.4 ± 5.5 6.0 ± 0.9 34 ± 6 5.8 ± 1.3 0.6 ± 1.2 
GroupAdjacent normal lung
Tumor cells
Tumor-associated endothelial cells
% Ki67% TUNEL% Ki67% TUNELCD31% Ki67% TUNEL
NCI-H441        
Vehicle 0.1 ± 0.3 0.1 ± 0.3 48.8 ± 4.5 0.6 ± 0.6 45 ± 4 8.2 ± 2.3 0.4 ± 1.0 
AEE788 0.1 ± 0.2 0.1 ± 0.3 9.4 ± 4.4* 17.7 ± 2.0* 9 ± 2* 1.8 ± 2.7* 21.1 ± 6.8* 
PC14-PE6        
Vehicle 0.3 ± 0.4 0.1 ± 0.3 50.0 ± 12.2 0.6 ± 0.3 36 ± 6 6.5 ± 1.9 0.5 ± 1.1 
AEE788 0.1 ± 0.3 0.1 ± 0.3 46.4 ± 5.5 6.0 ± 0.9 34 ± 6 5.8 ± 1.3 0.6 ± 1.2 

NOTE: % Ki67 is the ratio of the number of proliferating cells to total number of cells in 10 random ×200 fields. % TUNEL is the ratio of the number of apoptotic cells to total number of cells in 10 random ×200 fields. Data are presented as mean ± SE.

*

P < 0.01, compared with vehicle control according to Student's two-tailed t test.

Close Modal

or Create an Account

Close Modal
Close Modal