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Table 1.

Effects of systemic administration of AEE788 on NCI-H441 or PC14-PE6 human lung adenocarcinomas growing orthotopically in the lungs of nude mice

GroupLung tumor
Pleural effusion (incidence)Metastasis to lymph nodes (incidence)
Body weight (g), median (range)IncidenceWeight (g), median (range)
NCI-H441      
    Vehicle 27.8 (21.1-33.6) 20/20 0.4 (0.1-0.9) 18/20 20/20 
    AEE788 27.5 (23.3-32.7) 13/20* 0.03 (0-0.1) 0/20 1/20 
PC14-PE6      
    Vehicle 27.8 (23.3-34.5) 16/16 0.2 (0.02-0.5) 14/16 16/16 
    AEE788 27.3 (24.1-34.5) 16/16 0.2 (0.01-0.7) 8/16 16/16 
GroupLung tumor
Pleural effusion (incidence)Metastasis to lymph nodes (incidence)
Body weight (g), median (range)IncidenceWeight (g), median (range)
NCI-H441      
    Vehicle 27.8 (21.1-33.6) 20/20 0.4 (0.1-0.9) 18/20 20/20 
    AEE788 27.5 (23.3-32.7) 13/20* 0.03 (0-0.1) 0/20 1/20 
PC14-PE6      
    Vehicle 27.8 (23.3-34.5) 16/16 0.2 (0.02-0.5) 14/16 16/16 
    AEE788 27.3 (24.1-34.5) 16/16 0.2 (0.01-0.7) 8/16 16/16 

NOTE: NCI-H441 or PC14-PE6 cells (2.5 × 105) were injected into the left lobe of the lung. Treatment with AEE788 (50 mg/kg orally thrice weekly) or vehicle control was initiated 5 d after tumor injection. All mice were killed and tumors were harvested 24 (NCI-H441) or 26 (PC14-PE6) days after tumor injection when mice in the control group became moribund. Lung tumor weight was determined by subtracting the normal lung weight (0.17 g) from the weight of the tumor-containing lung.

*

P < 0.05, compared with vehicle control according to the χ2 test (for incidence) and Student's two-tailed t test.

P < 0.001, compared with vehicle control according to the χ2 test (for incidence) and Student's two-tailed t test.

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