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Table 2.

RR (95% CI) for lung cancer according to baseline serum 25(OH)D level

Tertile (range)Serum 25(OH)D
Ptrend
First (5.0-34.0 in men and 4.0-30.0 in women)Second (35.0-51.0 in men and 31.0-46.0 in women)Third (52.0-180.0 in men and 47.0-51.0 in women)
All     
    No. lung cancer cases 53 41 28  
    Univariate regression model* 1.0 0.80 (0.53-1.21) 0.55 (0.35-0.87) 0.01 
    Multiple regression model 1.0 0.96 (0.63-1.45) 0.72 (0.43-1.19) 0.22 
     
Men     
    No. lung cancer cases 37 35 25  
    Univariate regression model* 1.0 1.04 (0.65-1.66) 0.74 (0.44-1.23) 0.26 
    Multiple regression model 1.0 1.29 (0.80-2.09) 1.03 (0.59-1.82) 0.81 
Women     
    No. lung cancer cases 16  
    Univariate regression model* 1.0 0.31 (0.12-0.79) 0.15 (0.04-0.53) <0.001 
    Multiple regression model 1.0 0.28 (0.11-0.74) 0.16 (0.04-0.59) <0.001 
Pinteraction = 0.02     
     
Age ≤50 y     
    No. lung cancer cases 19 17  
    Univariate regression model* 1.0 0.72 (0.37-1.39) 0.28 (0.12-0.67) 0.003 
    Multiple regression model 1.0 0.89 (0.45-1.74) 0.34 (0.13-0.90) 0.04 
Age >50 y     
    No. lung cancer cases 22 51  
    Univariate regression model* 1.0 0.81 (0.48-1.37) 0.73 (0.42-1.26) 0.24 
    Multiple regression model 1.0 0.95 (0.55-1.64) 0.92 (0.50-1.70) 0.79 
Pinteraction = 0.02     
Tertile (range)Serum 25(OH)D
Ptrend
First (5.0-34.0 in men and 4.0-30.0 in women)Second (35.0-51.0 in men and 31.0-46.0 in women)Third (52.0-180.0 in men and 47.0-51.0 in women)
All     
    No. lung cancer cases 53 41 28  
    Univariate regression model* 1.0 0.80 (0.53-1.21) 0.55 (0.35-0.87) 0.01 
    Multiple regression model 1.0 0.96 (0.63-1.45) 0.72 (0.43-1.19) 0.22 
     
Men     
    No. lung cancer cases 37 35 25  
    Univariate regression model* 1.0 1.04 (0.65-1.66) 0.74 (0.44-1.23) 0.26 
    Multiple regression model 1.0 1.29 (0.80-2.09) 1.03 (0.59-1.82) 0.81 
Women     
    No. lung cancer cases 16  
    Univariate regression model* 1.0 0.31 (0.12-0.79) 0.15 (0.04-0.53) <0.001 
    Multiple regression model 1.0 0.28 (0.11-0.74) 0.16 (0.04-0.59) <0.001 
Pinteraction = 0.02     
     
Age ≤50 y     
    No. lung cancer cases 19 17  
    Univariate regression model* 1.0 0.72 (0.37-1.39) 0.28 (0.12-0.67) 0.003 
    Multiple regression model 1.0 0.89 (0.45-1.74) 0.34 (0.13-0.90) 0.04 
Age >50 y     
    No. lung cancer cases 22 51  
    Univariate regression model* 1.0 0.81 (0.48-1.37) 0.73 (0.42-1.26) 0.24 
    Multiple regression model 1.0 0.95 (0.55-1.64) 0.92 (0.50-1.70) 0.79 
Pinteraction = 0.02     
*

Univariate regression model: RRs were adjusted for age (as a continuous variable) and sex (when appropriate) only.

Multiple regression model: RRs were adjusted for age (as a continuous variable), marital status (unmarried, married and those who were in a common law marriage, widowed, and divorced), education (low and high), BMI (<23, 23.0-29.9, and ≥30 kg/m2), alcohol consumption (0, 1-14.9, and ≥15 g/wk ethanol), smoking (nonsmokers, smokers with low cotinine, smokers with average cotinine, and smokers with high cotinine), and season of baseline measurement (Summer: June-September and non-Summer: October-May,) as well as sex (when appropriate).

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