RR (95% CI) for lung cancer according to baseline serum 25(OH)D level
| Tertile (range) . | Serum 25(OH)D . | . | . | Ptrend . | ||||
|---|---|---|---|---|---|---|---|---|
| . | First (5.0-34.0 in men and 4.0-30.0 in women) . | Second (35.0-51.0 in men and 31.0-46.0 in women) . | Third (52.0-180.0 in men and 47.0-51.0 in women) . | . | ||||
| All | ||||||||
| No. lung cancer cases | 53 | 41 | 28 | |||||
| Univariate regression model* | 1.0 | 0.80 (0.53-1.21) | 0.55 (0.35-0.87) | 0.01 | ||||
| Multiple regression model† | 1.0 | 0.96 (0.63-1.45) | 0.72 (0.43-1.19) | 0.22 | ||||
| Men | ||||||||
| No. lung cancer cases | 37 | 35 | 25 | |||||
| Univariate regression model* | 1.0 | 1.04 (0.65-1.66) | 0.74 (0.44-1.23) | 0.26 | ||||
| Multiple regression model† | 1.0 | 1.29 (0.80-2.09) | 1.03 (0.59-1.82) | 0.81 | ||||
| Women | ||||||||
| No. lung cancer cases | 16 | 6 | 3 | |||||
| Univariate regression model* | 1.0 | 0.31 (0.12-0.79) | 0.15 (0.04-0.53) | <0.001 | ||||
| Multiple regression model† | 1.0 | 0.28 (0.11-0.74) | 0.16 (0.04-0.59) | <0.001 | ||||
| Pinteraction = 0.02 | ||||||||
| Age ≤50 y | ||||||||
| No. lung cancer cases | 19 | 17 | 7 | |||||
| Univariate regression model* | 1.0 | 0.72 (0.37-1.39) | 0.28 (0.12-0.67) | 0.003 | ||||
| Multiple regression model† | 1.0 | 0.89 (0.45-1.74) | 0.34 (0.13-0.90) | 0.04 | ||||
| Age >50 y | ||||||||
| No. lung cancer cases | 22 | 51 | 6 | |||||
| Univariate regression model* | 1.0 | 0.81 (0.48-1.37) | 0.73 (0.42-1.26) | 0.24 | ||||
| Multiple regression model† | 1.0 | 0.95 (0.55-1.64) | 0.92 (0.50-1.70) | 0.79 | ||||
| Pinteraction = 0.02 | ||||||||
| Tertile (range) . | Serum 25(OH)D . | . | . | Ptrend . | ||||
|---|---|---|---|---|---|---|---|---|
| . | First (5.0-34.0 in men and 4.0-30.0 in women) . | Second (35.0-51.0 in men and 31.0-46.0 in women) . | Third (52.0-180.0 in men and 47.0-51.0 in women) . | . | ||||
| All | ||||||||
| No. lung cancer cases | 53 | 41 | 28 | |||||
| Univariate regression model* | 1.0 | 0.80 (0.53-1.21) | 0.55 (0.35-0.87) | 0.01 | ||||
| Multiple regression model† | 1.0 | 0.96 (0.63-1.45) | 0.72 (0.43-1.19) | 0.22 | ||||
| Men | ||||||||
| No. lung cancer cases | 37 | 35 | 25 | |||||
| Univariate regression model* | 1.0 | 1.04 (0.65-1.66) | 0.74 (0.44-1.23) | 0.26 | ||||
| Multiple regression model† | 1.0 | 1.29 (0.80-2.09) | 1.03 (0.59-1.82) | 0.81 | ||||
| Women | ||||||||
| No. lung cancer cases | 16 | 6 | 3 | |||||
| Univariate regression model* | 1.0 | 0.31 (0.12-0.79) | 0.15 (0.04-0.53) | <0.001 | ||||
| Multiple regression model† | 1.0 | 0.28 (0.11-0.74) | 0.16 (0.04-0.59) | <0.001 | ||||
| Pinteraction = 0.02 | ||||||||
| Age ≤50 y | ||||||||
| No. lung cancer cases | 19 | 17 | 7 | |||||
| Univariate regression model* | 1.0 | 0.72 (0.37-1.39) | 0.28 (0.12-0.67) | 0.003 | ||||
| Multiple regression model† | 1.0 | 0.89 (0.45-1.74) | 0.34 (0.13-0.90) | 0.04 | ||||
| Age >50 y | ||||||||
| No. lung cancer cases | 22 | 51 | 6 | |||||
| Univariate regression model* | 1.0 | 0.81 (0.48-1.37) | 0.73 (0.42-1.26) | 0.24 | ||||
| Multiple regression model† | 1.0 | 0.95 (0.55-1.64) | 0.92 (0.50-1.70) | 0.79 | ||||
| Pinteraction = 0.02 | ||||||||
Univariate regression model: RRs were adjusted for age (as a continuous variable) and sex (when appropriate) only.
Multiple regression model: RRs were adjusted for age (as a continuous variable), marital status (unmarried, married and those who were in a common law marriage, widowed, and divorced), education (low and high), BMI (<23, 23.0-29.9, and ≥30 kg/m2), alcohol consumption (0, 1-14.9, and ≥15 g/wk ethanol), smoking (nonsmokers, smokers with low cotinine, smokers with average cotinine, and smokers with high cotinine), and season of baseline measurement (Summer: June-September and non-Summer: October-May,) as well as sex (when appropriate).