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Table 4.

Enterolactone concentrations, fiber intakes, and odds ratios (95 % CI) for breast cancer across quartiles of plasma enterolactone concentration in women from the MDC cohort, 1991 to 2004

Quartiles of ENL concentration
P for trend
1234
ENL concentration (nmol/L), median (range)* 4.9 (0.3-8.4) 11.6 (8.5-16.1) 21.1 (16.1-26.1) 36.8 (26.3-334.4)  
Fiber intake (g/d), median* 17.6 17.2 18.9 19.7 <0.001 
All women      
    Age (y), median 56.4 56.3 56.7 55.4 0.83 
    Cases/controls 100/183 104/183 78/185 84/182  
    OR (95 % CI) 1.00 1.06 (0.74-1.51) 0.77 (0.53-1.11) 0.84 (0.58-1.20) 0.16 
    OR (95 % CI) 1.00 1.03 (0.70-1.52) 0.70 (0.46-1.06) 0.81 (0.55-1.20) 0.14 
Women above 50 years + exclusion of cases with diagnosis within 1 y      
    Cases/controls 73/145 80/133 66/134 57/136  
    OR (95 % CI) 1.00 1.23 (0.82-1.86) 0.99 (0.65-1.50) 0.84 (0.55.1.27) 0.30 
    OR (95 % CI) 1.00 1.25 (0.78-2.00) 0.89 (0.55-1.45) 0.73 (0.45-1.19) 0.13 
    OR(95 % CI; 2nd quartile as reference) 0.80 (0.50-1.28) 1.00 0.71 (0.44-1.15) 0.59 (0.35-0.97) 0.04§ 
Quartiles of ENL concentration
P for trend
1234
ENL concentration (nmol/L), median (range)* 4.9 (0.3-8.4) 11.6 (8.5-16.1) 21.1 (16.1-26.1) 36.8 (26.3-334.4)  
Fiber intake (g/d), median* 17.6 17.2 18.9 19.7 <0.001 
All women      
    Age (y), median 56.4 56.3 56.7 55.4 0.83 
    Cases/controls 100/183 104/183 78/185 84/182  
    OR (95 % CI) 1.00 1.06 (0.74-1.51) 0.77 (0.53-1.11) 0.84 (0.58-1.20) 0.16 
    OR (95 % CI) 1.00 1.03 (0.70-1.52) 0.70 (0.46-1.06) 0.81 (0.55-1.20) 0.14 
Women above 50 years + exclusion of cases with diagnosis within 1 y      
    Cases/controls 73/145 80/133 66/134 57/136  
    OR (95 % CI) 1.00 1.23 (0.82-1.86) 0.99 (0.65-1.50) 0.84 (0.55.1.27) 0.30 
    OR (95 % CI) 1.00 1.25 (0.78-2.00) 0.89 (0.55-1.45) 0.73 (0.45-1.19) 0.13 
    OR(95 % CI; 2nd quartile as reference) 0.80 (0.50-1.28) 1.00 0.71 (0.44-1.15) 0.59 (0.35-0.97) 0.04§ 

Abbreviation: OR, odds ratio; ENL, enterolactone.

*

Estimated for all women (n = 1099).

Crude analysis.

Adjusted for weight, height, educational status, smoking habits, leisure-time physical activity, household activities, alcohol habits, age at menopause, parity, age at birth of first child, and current use of menopausal hormone therapy.

§

Test of trend from quartiles 2 to 4.

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