Description of 151 high-risk pancreatic cancer families
| . | Mayo Clinic, n = 41 (%) . | Johns Hopkins, n = 101 (%) . | Toronto, n = 9 (%) . | Total, n = 151 (%) . | ||||
|---|---|---|---|---|---|---|---|---|
| No. pancreatic cancers | ||||||||
| 2 | 37 (90) | 77 (76) | 7 (78) | 121 (80) | ||||
| 3 | 3 (7) | 16 (16) | 2 (22) | 21 (14) | ||||
| ≥4 | 1 (3) | 8 (8) | 0 (0) | 9 (6) | ||||
| Family history of pancreatic cancer | ||||||||
| ≥2 First-degree relatives | 24 (59) | 89 (88) | 5 (56) | 118 (78) | ||||
| ≥2 Second-degree relatives | 17 (41) | 12 (12) | 4 (44) | 33 (22) | ||||
| Other cancers | ||||||||
| Breast | 17 (41) | 32 (32) | 3 (33) | 52 (34) | ||||
| Ovarian | 5 (12) | 7 (7) | 0 (0) | 12 (8) | ||||
| Prostate | 13 (32) | 16 (16) | 0 (0) | 29 (19) | ||||
| Proband age of onset | ||||||||
| ≤55 | 12 (29) | 28 (28) | 3 (33) | 43 (28) | ||||
| >55 | 29 (71) | 73 (72) | 6 (67) | 108 (72) | ||||
| . | Mayo Clinic, n = 41 (%) . | Johns Hopkins, n = 101 (%) . | Toronto, n = 9 (%) . | Total, n = 151 (%) . | ||||
|---|---|---|---|---|---|---|---|---|
| No. pancreatic cancers | ||||||||
| 2 | 37 (90) | 77 (76) | 7 (78) | 121 (80) | ||||
| 3 | 3 (7) | 16 (16) | 2 (22) | 21 (14) | ||||
| ≥4 | 1 (3) | 8 (8) | 0 (0) | 9 (6) | ||||
| Family history of pancreatic cancer | ||||||||
| ≥2 First-degree relatives | 24 (59) | 89 (88) | 5 (56) | 118 (78) | ||||
| ≥2 Second-degree relatives | 17 (41) | 12 (12) | 4 (44) | 33 (22) | ||||
| Other cancers | ||||||||
| Breast | 17 (41) | 32 (32) | 3 (33) | 52 (34) | ||||
| Ovarian | 5 (12) | 7 (7) | 0 (0) | 12 (8) | ||||
| Prostate | 13 (32) | 16 (16) | 0 (0) | 29 (19) | ||||
| Proband age of onset | ||||||||
| ≤55 | 12 (29) | 28 (28) | 3 (33) | 43 (28) | ||||
| >55 | 29 (71) | 73 (72) | 6 (67) | 108 (72) | ||||