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Table 6.

Association between relative telomere length, cigarette smoking, and bladder cancer risk

Relative telomere lengthCases, n (%)Controls, n (%)OR (95% CI)*
NHS    
Never cigarette smoker    
    ≥ Median 8 (42.1) 9 (40.9) 1.00 ref 
    < Median 11 (57.9) 13 (59.1) 0.96 (0.28, 3.36) 
Ever cigarette smoker    
    ≥ Median 13 (31.0) 25 (55.6) 1.00 ref 
    < Median 29 (69.1) 20 (44.4) 3.31 (1.33, 8.27) 
HPFS    
Never cigarette smoker    
    ≥ Median 16 (41.0) 18 (47.4) 1.00 ref 
    < Median 23 (59.0) 20 (52.6) 1.30 (0.52, 3.21) 
Ever cigarette smoker    
    ≥ Median 28 (33.7) 45 (52.9) 1.00 ref 
    < Median 55 (66.3) 40 (47.1) 2.31 (1.21, 4.41) 
NHS + HPFS    
Never cigarette smoker    
    ≥ Median 24 (41.4) 27 (45.0) 1.00 ref 
    < Median 34 (58.6) 33 (55.0) 1.16 (0.56, 2.41) 
Ever cigarette smoker    
    ≥ Median 41 (32.8) 70 (53.9) 1.00 ref 
    < Median 84 (67.2) 60 (46.2) 2.63 (1.56, 4.45) 
Relative telomere lengthCases, n (%)Controls, n (%)OR (95% CI)*
NHS    
Never cigarette smoker    
    ≥ Median 8 (42.1) 9 (40.9) 1.00 ref 
    < Median 11 (57.9) 13 (59.1) 0.96 (0.28, 3.36) 
Ever cigarette smoker    
    ≥ Median 13 (31.0) 25 (55.6) 1.00 ref 
    < Median 29 (69.1) 20 (44.4) 3.31 (1.33, 8.27) 
HPFS    
Never cigarette smoker    
    ≥ Median 16 (41.0) 18 (47.4) 1.00 ref 
    < Median 23 (59.0) 20 (52.6) 1.30 (0.52, 3.21) 
Ever cigarette smoker    
    ≥ Median 28 (33.7) 45 (52.9) 1.00 ref 
    < Median 55 (66.3) 40 (47.1) 2.31 (1.21, 4.41) 
NHS + HPFS    
Never cigarette smoker    
    ≥ Median 24 (41.4) 27 (45.0) 1.00 ref 
    < Median 34 (58.6) 33 (55.0) 1.16 (0.56, 2.41) 
Ever cigarette smoker    
    ≥ Median 41 (32.8) 70 (53.9) 1.00 ref 
    < Median 84 (67.2) 60 (46.2) 2.63 (1.56, 4.45) 
*

Unconditional logistic regression adjusted for the matching factors (age, smoking status), gender, and pack-years of smoking among smokers only.

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