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Table 1

Multivariate adjusted mean levels of IGF-I and IGFBP-3, by category of lifestyle factor

All factors are mutually adjusted for each other plus laboratory batch and menopausal status. Ps refer to the linear trend test for ordinal variables (age, BMI, physical activity, parity) and a test of difference between extreme categories for nonordinal variables (smoking = never versus current; lactation, hormone use = never versus oral estrogen only, duration of oral estrogen + progesterone).

Category definitionIGF-I (ng/ml)IGFBP-3 (ng/ml)
Age (yr) <45 218 3974 
 45–49 199 3953 
 50–54 185 3966 
 55–59 177 3973 
 60–64 184 4154 
  P = 0.006 P = 0.24 
Body Mass Index (kg/m2<21 184 3879 
 21–22.9 192 3916 
 23–24.9 197 4073 
 25–28.9 192 4054 
 ≥29 181 4080 
  P = 0.66 P = 0.01 
Smoking Never 190 3994 
 Past 195 4075 
 Current 176 3847 
  P = 0.03 P = 0.07 
Physical Activity (MET-hours/week) <4 184 3961 
 4–11.9 186 4064 
 12–24.9 195 4020 
 ≥25 194 3977 
  P = 0.07 P = 0.79 
Parity 212 4047 
 190 3939 
 192 4048 
 192 4016 
 ≥4 180 3924 
  P = 0.003 P = 0.29 
Lactationa Never 182 3862 
 Ever 192 4069 
  P = 0.05 P = 0.002 
Hormone useb Never 181 4239 
 Current oral estrogen + progesterone 143 3979 
 Current oral estrogen only 116 3942 
  P = 0.0001 P = 0.02 
Duration of oral estrogen + progesteroneb <5 yr 157 4123 
 ≥5 yr 122 3765 
  P = 0.01 P = 0.09 
Category definitionIGF-I (ng/ml)IGFBP-3 (ng/ml)
Age (yr) <45 218 3974 
 45–49 199 3953 
 50–54 185 3966 
 55–59 177 3973 
 60–64 184 4154 
  P = 0.006 P = 0.24 
Body Mass Index (kg/m2<21 184 3879 
 21–22.9 192 3916 
 23–24.9 197 4073 
 25–28.9 192 4054 
 ≥29 181 4080 
  P = 0.66 P = 0.01 
Smoking Never 190 3994 
 Past 195 4075 
 Current 176 3847 
  P = 0.03 P = 0.07 
Physical Activity (MET-hours/week) <4 184 3961 
 4–11.9 186 4064 
 12–24.9 195 4020 
 ≥25 194 3977 
  P = 0.07 P = 0.79 
Parity 212 4047 
 190 3939 
 192 4048 
 192 4016 
 ≥4 180 3924 
  P = 0.003 P = 0.29 
Lactationa Never 182 3862 
 Ever 192 4069 
  P = 0.05 P = 0.002 
Hormone useb Never 181 4239 
 Current oral estrogen + progesterone 143 3979 
 Current oral estrogen only 116 3942 
  P = 0.0001 P = 0.02 
Duration of oral estrogen + progesteroneb <5 yr 157 4123 
 ≥5 yr 122 3765 
  P = 0.01 P = 0.09 
a

Parous women only.

b

Postmenopausal women only.

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