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Table 3.

RR and 95% CI values for the association between recent weight change (1982-1992) and prostate cancer incidence (CPS-II Nutrition Cohort, 1992-2003)

Recent weight change from 1982-1992 (pounds)
Weight loss
Loss or gain
Weight gain
−21+−11 to −20−6 to −10−5 to 56-1011-2021+
All cases        
    No. of cases* 113 349 541 2,450 751 687 322 
    Person-years 12,624 36,330 47,110 211,790 68,515 65,495 35,227 
    RR (95% CI) 0.76 (0.63-0.92) 0.81 (0.72-0.90) 0.97 (0.89-1.07) 1.00 (ref) 0.97 (0.89-1.05) 0.95 (0.87-1.03) 0.85 (0.75-0.95) 
    RR (95% CI) 0.83 (0.69-1.01) 0.84 (0.75-0.94) 0.98 (0.89-1.08) 1.00 (ref) 0.98 (0.90-1.06) 0.96 (0.88-1.05) 0.88 (0.79-0.99) 
    RR (95% CI)§ 0.84 (0.69-1.02) 0.84 (0.75-0.95) 0.98 (0.89-1.08) 1.00 (ref) 0.98 (0.90-1.06) 0.97 (0.89-1.05) 0.89 (0.79-1.00) 
Nonmetastatic low grade        
    No. of cases* 83 284 427 1,908 606 545 251 
    Person-years 12,624 36,330 47,110 211,790 68,515 65,495 35,227 
    RR (95% CI) 0.73 (0.58-0.91) 0.86 (0.76-0.97) 1.00 (0.90-1.11) 1.00 (ref) 1.00 (0.91-1.09) 0.95 (0.86-1.05) 0.83 (0.73-0.95) 
    RR (95% CI) 0.81 (0.65-1.01) 0.90 (0.79-1.02) 1.01 (0.91-1.12) 1.00 (ref) 1.01 (0.92-1.10) 0.97 (0.88-1.07) 0.88 (0.77-1.00) 
    RR (95% CI)§ 0.85 (0.68-1.06) 0.91 (0.81-1.04) 1.01 (0.91-1.13) 1.00 (ref) 1.01 (0.92-1.11) 0.98 (0.89-1.08) 0.89 (0.78-1.02) 
Nonmetastatic high grade        
    No. of cases*  45 66 332 87 129  
    Person-years  48,954 47,110 211,790 68,515 100,722  
    RR (95% CI)  0.56 (0.41-0.77) 0.86 (0.66-1.12) 1.00 (ref) 0.84 (0.66-1.07) 0.88 (0.72-1.08)**  
    RR (95% CI)  0.58 (0.42-0.79) 0.86 (0.66-1.12) 1.00 (ref) 0.85 (0.67-1.07) 0.90 (0.73-1.11)**  
    RR (95% CI)§  0.55 (0.40-0.75) 0.85 (0.65-1.10) 1.00 (ref) 0.84 (0.67-1.07) 0.88 (0.71-1.08)**  
Stage D or fatal cases        
    No. of cases*  31 28 137 33 57  
    Person-years  48,954 47,110 211,790 68,515 100,722  
    RR (95% CI)  0.85 (0.58-1.26) 0.82 (0.55-1.24) 1.00 (ref) 0.81 (0.55-1.18) 1.02 (0.75-1.39)**  
    RR (95% CI)  0.87 (0.59-1.30) 0.84 (0.56-1.26) 1.00 (ref) 0.80 (0.55-1.17) 0.99 (0.72-1.35)**  
    RR (95% CI)§  0.83 (0.56-1.24) 0.83 (0.55-1.24) 1.00 (ref) 0.80 (0.54-1.17) 0.97 (0.71-1.33)**  
Recent weight change from 1982-1992 (pounds)
Weight loss
Loss or gain
Weight gain
−21+−11 to −20−6 to −10−5 to 56-1011-2021+
All cases        
    No. of cases* 113 349 541 2,450 751 687 322 
    Person-years 12,624 36,330 47,110 211,790 68,515 65,495 35,227 
    RR (95% CI) 0.76 (0.63-0.92) 0.81 (0.72-0.90) 0.97 (0.89-1.07) 1.00 (ref) 0.97 (0.89-1.05) 0.95 (0.87-1.03) 0.85 (0.75-0.95) 
    RR (95% CI) 0.83 (0.69-1.01) 0.84 (0.75-0.94) 0.98 (0.89-1.08) 1.00 (ref) 0.98 (0.90-1.06) 0.96 (0.88-1.05) 0.88 (0.79-0.99) 
    RR (95% CI)§ 0.84 (0.69-1.02) 0.84 (0.75-0.95) 0.98 (0.89-1.08) 1.00 (ref) 0.98 (0.90-1.06) 0.97 (0.89-1.05) 0.89 (0.79-1.00) 
Nonmetastatic low grade        
    No. of cases* 83 284 427 1,908 606 545 251 
    Person-years 12,624 36,330 47,110 211,790 68,515 65,495 35,227 
    RR (95% CI) 0.73 (0.58-0.91) 0.86 (0.76-0.97) 1.00 (0.90-1.11) 1.00 (ref) 1.00 (0.91-1.09) 0.95 (0.86-1.05) 0.83 (0.73-0.95) 
    RR (95% CI) 0.81 (0.65-1.01) 0.90 (0.79-1.02) 1.01 (0.91-1.12) 1.00 (ref) 1.01 (0.92-1.10) 0.97 (0.88-1.07) 0.88 (0.77-1.00) 
    RR (95% CI)§ 0.85 (0.68-1.06) 0.91 (0.81-1.04) 1.01 (0.91-1.13) 1.00 (ref) 1.01 (0.92-1.11) 0.98 (0.89-1.08) 0.89 (0.78-1.02) 
Nonmetastatic high grade        
    No. of cases*  45 66 332 87 129  
    Person-years  48,954 47,110 211,790 68,515 100,722  
    RR (95% CI)  0.56 (0.41-0.77) 0.86 (0.66-1.12) 1.00 (ref) 0.84 (0.66-1.07) 0.88 (0.72-1.08)**  
    RR (95% CI)  0.58 (0.42-0.79) 0.86 (0.66-1.12) 1.00 (ref) 0.85 (0.67-1.07) 0.90 (0.73-1.11)**  
    RR (95% CI)§  0.55 (0.40-0.75) 0.85 (0.65-1.10) 1.00 (ref) 0.84 (0.67-1.07) 0.88 (0.71-1.08)**  
Stage D or fatal cases        
    No. of cases*  31 28 137 33 57  
    Person-years  48,954 47,110 211,790 68,515 100,722  
    RR (95% CI)  0.85 (0.58-1.26) 0.82 (0.55-1.24) 1.00 (ref) 0.81 (0.55-1.18) 1.02 (0.75-1.39)**  
    RR (95% CI)  0.87 (0.59-1.30) 0.84 (0.56-1.26) 1.00 (ref) 0.80 (0.55-1.17) 0.99 (0.72-1.35)**  
    RR (95% CI)§  0.83 (0.56-1.24) 0.83 (0.55-1.24) 1.00 (ref) 0.80 (0.54-1.17) 0.97 (0.71-1.33)**  
*

Case numbers may not sum to total 5,252 due to exclusions of extreme values of weight in 1982 and missing data.

Adjusted for age at interview.

Adjusted for age at interview, race, education, family history of prostate cancer, total calorie intake, smoking status, history of PSA testing, history of diabetes, height, and physical activity.

§

Adjusted for age at interview, race, education, family history of prostate cancer, total calorie intake, smoking status, history of PSA testing, history of diabetes, height, physical activity, and BMI in 1982.

One hundred and sixty-four nonmetastatic low-grade cases excluded due to missing Gleason score information.

This value is for the weight loss of −11 to −20 and −21+ groups combined.

**

This value is for the weight gain of 11 to 20 and 21+ groups combined.

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