RR and 95% CI values for the association between BMI and prostate cancer incidence (CPS-II Nutrition Cohort, 1992-2003)
. | BMI in 1992 (kg/m2) . | . | . | . | . | Ptrend . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | <25.0 . | 25.0 to <27.5 . | 27.5 to <30.0 . | 30.0 to <35.0 . | ≥35.0 . | . | ||||||
| All cases | ||||||||||||
| No. of cases | 1,935 | 1,742 | 920 | 556 | 99 | |||||||
| Person-years | 171,338 | 153,585 | 87,652 | 57,508 | 11,344 | |||||||
| RR (95% CI)* | 1.00 (ref) | 1.02 (0.95-1.08) | 0.95 (0.88-1.03) | 0.89 (0.81-0.98) | 0.83 (0.68-1.02) | 0.003 | ||||||
| RR (95% CI)† | 1.00 (ref) | 1.02 (0.96-1.09) | 0.98 (0.90-1.06) | 0.94 (0.85-1.04) | 0.91 (0.75-1.12) | 0.14 | ||||||
| Nonmetastatic low grade‡ | ||||||||||||
| No. of cases | 1,544 | 1,409 | 700 | 412 | 73 | |||||||
| Person-years | 171,338 | 153,585 | 87,652 | 57,508 | 11,344 | |||||||
| RR (95% CI)* | 1.00 (ref) | 1.02 (0.95-1.09) | 0.89 (0.81-0.97) | 0.81 (0.72-0.90) | 0.75 (0.59-0.94) | <0.0001 | ||||||
| RR (95% CI)† | 1.00 (ref) | 1.03 (0.96-1.10) | 0.92 (0.84-1.01) | 0.86 (0.77-0.97) | 0.84 (0.66-1.06) | 0.002 | ||||||
| Nonmetastatic high grade‡ | ||||||||||||
| No. of cases | 239 | 180 | 140 | 103 | ||||||||
| Person-years | 171,338 | 153,585 | 87,652 | 68,852 | ||||||||
| RR (95% CI)* | 1.00 (ref) | 0.87 (0.71-1.05) | 1.21 (0.98-1.49) | 1.17 (0.93-1.48)§ | 0.06 | |||||||
| RR (95% CI)† | 1.00 (ref) | 0.87 (0.72-1.06) | 1.23 (1.00-1.53) | 1.22 (0.96-1.55)§ | 0.03 | |||||||
| Stage D or fatal cases | ||||||||||||
| No. of cases | 92 | 104 | 46 | 46 | ||||||||
| Person-years | 171,338 | 153,585 | 87,652 | 68,852 | ||||||||
| RR (95% CI)* | 1.00 (ref) | 1.40 (1.06-1.86) | 1.14 (0.80-1.63) | 1.57 (1.09-2.24)§ | 0.03 | |||||||
| RR (95% CI)† | 1.00 (ref) | 1.41 (1.06-1.87) | 1.14 (0.79-1.63) | 1.54 (1.06-2.23)§ | 0.05 | |||||||
. | BMI in 1992 (kg/m2) . | . | . | . | . | Ptrend . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | <25.0 . | 25.0 to <27.5 . | 27.5 to <30.0 . | 30.0 to <35.0 . | ≥35.0 . | . | ||||||
| All cases | ||||||||||||
| No. of cases | 1,935 | 1,742 | 920 | 556 | 99 | |||||||
| Person-years | 171,338 | 153,585 | 87,652 | 57,508 | 11,344 | |||||||
| RR (95% CI)* | 1.00 (ref) | 1.02 (0.95-1.08) | 0.95 (0.88-1.03) | 0.89 (0.81-0.98) | 0.83 (0.68-1.02) | 0.003 | ||||||
| RR (95% CI)† | 1.00 (ref) | 1.02 (0.96-1.09) | 0.98 (0.90-1.06) | 0.94 (0.85-1.04) | 0.91 (0.75-1.12) | 0.14 | ||||||
| Nonmetastatic low grade‡ | ||||||||||||
| No. of cases | 1,544 | 1,409 | 700 | 412 | 73 | |||||||
| Person-years | 171,338 | 153,585 | 87,652 | 57,508 | 11,344 | |||||||
| RR (95% CI)* | 1.00 (ref) | 1.02 (0.95-1.09) | 0.89 (0.81-0.97) | 0.81 (0.72-0.90) | 0.75 (0.59-0.94) | <0.0001 | ||||||
| RR (95% CI)† | 1.00 (ref) | 1.03 (0.96-1.10) | 0.92 (0.84-1.01) | 0.86 (0.77-0.97) | 0.84 (0.66-1.06) | 0.002 | ||||||
| Nonmetastatic high grade‡ | ||||||||||||
| No. of cases | 239 | 180 | 140 | 103 | ||||||||
| Person-years | 171,338 | 153,585 | 87,652 | 68,852 | ||||||||
| RR (95% CI)* | 1.00 (ref) | 0.87 (0.71-1.05) | 1.21 (0.98-1.49) | 1.17 (0.93-1.48)§ | 0.06 | |||||||
| RR (95% CI)† | 1.00 (ref) | 0.87 (0.72-1.06) | 1.23 (1.00-1.53) | 1.22 (0.96-1.55)§ | 0.03 | |||||||
| Stage D or fatal cases | ||||||||||||
| No. of cases | 92 | 104 | 46 | 46 | ||||||||
| Person-years | 171,338 | 153,585 | 87,652 | 68,852 | ||||||||
| RR (95% CI)* | 1.00 (ref) | 1.40 (1.06-1.86) | 1.14 (0.80-1.63) | 1.57 (1.09-2.24)§ | 0.03 | |||||||
| RR (95% CI)† | 1.00 (ref) | 1.41 (1.06-1.87) | 1.14 (0.79-1.63) | 1.54 (1.06-2.23)§ | 0.05 | |||||||
Adjusted for age at interview.
Adjusted for age at interview, race, education, family history of prostate cancer, total calorie intake, smoking status, history of PSA testing, history of diabetes, and physical activity.
One hundred and sixty-four nonmetastatic low-grade cases excluded due to missing Gleason score information.
This value is for BMI 30 to <35 and BMI ≥35 groups combined.