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Table 3

Variables associated univariately with breast cancer death and development of invasive cancer in either breast after a primary DCIS of the breast

VariableBreast cancer death OR (95% CI) [cases/controls]Subsequent invasive cancer OR (95% CI) [cases/controls]
IpsilateralContralateral
Total [39/99] [70/185] [48/129] 
Age    
 <50 yr 1.5 (0.5–4.3) [13/37] 0.6 (0.3–1.2) [19/69] 0.7 (0.3–1.6) [17/51] 
 50–59 yr Refa [7/28] Ref [17/37] Ref [13/26] 
 >59 yr 2.5 (0.8–7.8) [19/34] 1.2 (0.6–2.6) [34/79] 0.7 (0.3–1.6) [18/52] 
Mode of detection, mammography vs. clinical 0.8 (0.3–2.0) [37/98] 0.9 (0.4–1.8) [68/183] 1.8 (0.7–4.3) [46/125] 
Palpable, yes vs. no 1.2 (0.5–2.6) [38/98] 0.5 (0.3–1.0) [69/184] 0.5 (0.2–1.1) [47/124] 
Free margins, no or doubtful vs. yes 1.7 (0.3–10.3) [30/84] 1.3 (0.4–3.9) [45/160] 9.8 (2.0–46.7) [42/111] 
Size, ≥25 mm vs. <25 mm 3.5 (1.1–11.4) [24/65] 1.0 (0.4–2.2) [43/117] 1.5 (0.6–4.0) [25/73] 
Size, multifocal or multicentric vs. unifocal 3.9 (1.2–12.7) [24/65] 1.1 (0.5–2.5) [43/117] 1.1 (0.5–2.7) [25/73] 
Treatment    
 BCS Ref [13/32] Ref [48/60] Ref [10/29] 
 BCS + XRT 0.3 (0.0–2.9) [1/9] 0.1 (0.0–0.8) [2/13] 12.7 (1.4–115.8) [6/4] 
 Mastectomy 1.1 (0.5–2.8) [25/57] 0.2 (0.1–0.4) [18/104] 1.1 (0.5–2.5) [30/82] 
VariableBreast cancer death OR (95% CI) [cases/controls]Subsequent invasive cancer OR (95% CI) [cases/controls]
IpsilateralContralateral
Total [39/99] [70/185] [48/129] 
Age    
 <50 yr 1.5 (0.5–4.3) [13/37] 0.6 (0.3–1.2) [19/69] 0.7 (0.3–1.6) [17/51] 
 50–59 yr Refa [7/28] Ref [17/37] Ref [13/26] 
 >59 yr 2.5 (0.8–7.8) [19/34] 1.2 (0.6–2.6) [34/79] 0.7 (0.3–1.6) [18/52] 
Mode of detection, mammography vs. clinical 0.8 (0.3–2.0) [37/98] 0.9 (0.4–1.8) [68/183] 1.8 (0.7–4.3) [46/125] 
Palpable, yes vs. no 1.2 (0.5–2.6) [38/98] 0.5 (0.3–1.0) [69/184] 0.5 (0.2–1.1) [47/124] 
Free margins, no or doubtful vs. yes 1.7 (0.3–10.3) [30/84] 1.3 (0.4–3.9) [45/160] 9.8 (2.0–46.7) [42/111] 
Size, ≥25 mm vs. <25 mm 3.5 (1.1–11.4) [24/65] 1.0 (0.4–2.2) [43/117] 1.5 (0.6–4.0) [25/73] 
Size, multifocal or multicentric vs. unifocal 3.9 (1.2–12.7) [24/65] 1.1 (0.5–2.5) [43/117] 1.1 (0.5–2.7) [25/73] 
Treatment    
 BCS Ref [13/32] Ref [48/60] Ref [10/29] 
 BCS + XRT 0.3 (0.0–2.9) [1/9] 0.1 (0.0–0.8) [2/13] 12.7 (1.4–115.8) [6/4] 
 Mastectomy 1.1 (0.5–2.8) [25/57] 0.2 (0.1–0.4) [18/104] 1.1 (0.5–2.5) [30/82] 
a

Ref, Reference group with an odds ratio 1.0.

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