Relationship between alcohol use and risk of breast cancer by ER and PR status
Factor . | Controls n = 998 . | . | ER+ n = 789 . | . | ORa . | 95% CI . | ER− n = 106 . | . | OR . | 95% CI . | PR+ n = 648 . | . | OR . | 95% CI . | PR− n = 244 . | . | OR . | 95% CI . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | N . | % . | N . | % . | . | . | N . | % . | . | . | N . | % . | . | . | N . | % . | . | . | |||||
Alcohol use (g/day) | |||||||||||||||||||||||
Never | 514 | 51.5 | 370 | 47.0 | 1.0 | (ref) | 53 | 50.0 | 1.0 | (ref) | 300 | 46.3 | 1.0 | (ref) | 122 | 49.8 | 1.0 | (ref) | |||||
Ever | 484 | 48.5 | 419 | 53.1 | 1.3 | (1.0–1.6)b | 53 | 50.0 | 1.1 | (0.7–1.7) | 348 | 53.7 | 1.3 | (1.1–1.7)b | 122 | 50.0 | 1.1 | (0.8–1.4) | |||||
<1.5 | 59 | 5.9 | 48 | 6.1 | 1.2 | (0.8–1.8) | 6 | 5.7 | 1.1 | (0.4–2.7) | 41 | 6.3 | 1.2 | (0.8–1.9) | 13 | 5.3 | 1.0 | (0.5–1.9) | |||||
1.5–4.9 | 121 | 12.2 | 109 | 13.8 | 1.6 | (1.0–1.8) | 12 | 11.3 | 1.1 | (0.5–2.1) | 92 | 14.2 | 1.4 | (1.0–2.0)b | 29 | 11.9 | 1.0 | (0.6–1.6) | |||||
5.0–14.9 | 167 | 16.6 | 133 | 16.9 | 1.2 | (0.9–1.6) | 18 | 17.0 | 1.0 | (0.6–1.9) | 107 | 16.5 | 1.2 | (0.9–1.6) | 43 | 17.6 | 1.1 | (0.7–1.6) | |||||
15.0–29.9 | 91 | 9.2 | 76 | 9.6 | 1.2 | (0.9–1.8) | 12 | 11.3 | 1.4 | (0.7–2.7) | 65 | 10.0 | 1.3 | (0.9–1.9) | 22 | 9.0 | 1.1 | (0.6–1.8) | |||||
≥30.0 | 46 | 4.6 | 53 | 6.7 | 1.7 | (1.1–2.7)b | 5 | 4.7 | 1.2 | (0.5–3.2) | 43 | 6.6 | 1.8 | (1.1–2.8)b | 15 | 6.1 | 1.4 | (0.7–2.7) | |||||
P for trend | 0.705 | 0.544 | 0.998 | 0.702 | |||||||||||||||||||
Former | 77 | 7.7 | 57 | 7.2 | 1.1 | (0.8–1.7) | 8 | 7.5 | 1.1 | (0.5–2.5) | 47 | 7.3 | 1.2 | (0.8–1.8) | 18 | 7.4 | 1.0 | (0.6–1.8) | |||||
Current | 407 | 40.8 | 362 | 45.9 | 1.3 | (1.1–1.6)b | 45 | 42.5 | 1.1 | (0.7–1.8) | 301 | 46.5 | 1.4 | (1.1–1.7)b | 104 | 42.6 | 1.1 | (0.8–1.5) | |||||
<1.5 | 67 | 6.7 | 61 | 7.7 | 1.3 | (0.9–1.8) | 10 | 9.4 | 1.5 | (0.7–3.2) | 50 | 7.7 | 1.3 | (0.9–1.9) | 21 | 8.6 | 1.3 | (0.8–2.2) | |||||
1.5–4.9 | 87 | 8.7 | 76 | 9.6 | 1.3 | (0.9–1.8) | 8 | 7.5 | 1.0 | (0.4–2.1) | 67 | 10.3 | 1.4 | (1.0–2.1)b | 17 | 7.0 | 0.8 | (0.5–1.4) | |||||
5.0–14.9 | 138 | 13.8 | 114 | 14.4 | 1.2 | (0.9–1.7) | 10 | 9.4 | 0.8 | (0.4–1.6) | 94 | 14.5 | 1.3 | (0.9–1.8) | 29 | 11.9 | 0.9 | (0.5–1.4) | |||||
15.0–29.9 | 78 | 7.8 | 61 | 7.7 | 1.2 | (0.8–1.7) | 12 | 11.3 | 1.5 | (0.7–3.0) | 50 | 7.7 | 1.2 | (0.8–1.8) | 22 | 9.0 | 1.2 | (0.7–2.1) | |||||
≥30.0 | 37 | 3.7 | 50 | 6.3 | 1.9 | (1.2–3.1)b | 5 | 4.7 | 1.5 | (0.5–4.0) | 40 | 6.2 | 2.0 | (1.2–3.2)b | 15 | 6.1 | 1.7 | (0.9–3.3) | |||||
P for trend | 0.386 | 0.902 | 0.508 | 0.462 | |||||||||||||||||||
Alcohol use (g/day) | |||||||||||||||||||||||
Never | 514 | 51.5 | 298 | 46.4 | 1.0 | (ref) | 71 | 49.3 | 1.0 | (ref) | 51 | 51.0 | 1.0 | (ref) | |||||||||
Ever | 484 | 48.5 | 344 | 53.6 | 1.3 | (1.1–1.7)b | 73 | 50.7 | 1.1 | (0.7–1.5) | 49 | 49.0 | 1.1 | (0.7–1.7) | |||||||||
<1.5 | 59 | 5.9 | 41 | 6.4 | 1.2 | (0.8–1.9) | 7 | 4.9 | 0.9 | (0.4–2.1) | 6 | 6.0 | 1.1 | (0.5–2.7) | |||||||||
1.5–4.9 | 121 | 12.2 | 90 | 14.0 | 1.4 | (1.0–2.0)b | 19 | 13.2 | 1.0 | (0.6–1.8) | 10 | 10.0 | 0.9 | (0.4–1.9) | |||||||||
5.0–14.9 | 167 | 16.6 | 106 | 16.5 | 1.2 | (0.9–1.6) | 26 | 18.1 | 1.1 | (0.7–1.9) | 17 | 17.0 | 1.0 | (0.5–1.8) | |||||||||
15.0–29.9 | 91 | 9.2 | 64 | 10.0 | 1.3 | (0.9–1.9) | 11 | 7.6 | 0.9 | (0.4–7.8) | 11 | 11.0 | 1.3 | (0.6–2.6) | |||||||||
≥30.0 | 46 | 4.6 | 43 | 6.7 | 1.8 | (1.1–2.8)b | 10 | 6.9 | 1.5 | (0.7–3.3) | 5 | 5.0 | 1.2 | (0.5–3.3) | |||||||||
P for trend | 0.945 | 0.330 | 0.656 | ||||||||||||||||||||
Former | 77 | 7.7 | 46 | 7.2 | 1.2 | (0.8–1.8) | 11 | 7.6 | 1.1 | (0.5–2.2) | 7 | 7.0 | 0.9 | (0.4–2.3) | |||||||||
Current | 407 | 40.8 | 298 | 46.4 | 1.4 | (1.1–1.7)b | 62 | 43.1 | 1.1 | (0.7–1.6) | 42 | 42.0 | 1.1 | (0.7–1.7) | |||||||||
<1.5 | 67 | 6.7 | 50 | 7.8 | 1.3 | (0.9–1.9) | 11 | 7.6 | 1.1 | (0.5–2.3) | 10 | 10.0 | 1.6 | (0.7–3.3) | |||||||||
1.5–4.9 | 87 | 8.7 | 64 | 10.0 | 1.4 | (1.0–2.0)b | 12 | 8.3 | 1.0 | (0.5–1.9) | 5 | 5.0 | 0.6 | (0.2–1.6) | |||||||||
5.0–14.9 | 138 | 13.8 | 94 | 14.6 | 1.3 | (0.9–1.8) | 19 | 13.2 | 0.9 | (0.5–1.7) | 10 | 10.0 | 0.8 | (0.4–1.6) | |||||||||
15.0–29.9 | 78 | 7.8 | 50 | 7.8 | 1.2 | (0.8–1.8) | 10 | 6.9 | 1.0 | (0.5–2.1) | 12 | 12.0 | 1.5 | (0.7–3.1) | |||||||||
≥30.0 | 37 | 3.7 | 40 | 6.2 | 2.0 | (1.2–3.3)b | 10 | 6.9 | 1.8 | (0.8–4.0) | 5 | 5.0 | 1.5 | (0.6–4.1) | |||||||||
P for trend | 0.439 | 0.548 | 0.367 |
Factor . | Controls n = 998 . | . | ER+ n = 789 . | . | ORa . | 95% CI . | ER− n = 106 . | . | OR . | 95% CI . | PR+ n = 648 . | . | OR . | 95% CI . | PR− n = 244 . | . | OR . | 95% CI . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | N . | % . | N . | % . | . | . | N . | % . | . | . | N . | % . | . | . | N . | % . | . | . | |||||
Alcohol use (g/day) | |||||||||||||||||||||||
Never | 514 | 51.5 | 370 | 47.0 | 1.0 | (ref) | 53 | 50.0 | 1.0 | (ref) | 300 | 46.3 | 1.0 | (ref) | 122 | 49.8 | 1.0 | (ref) | |||||
Ever | 484 | 48.5 | 419 | 53.1 | 1.3 | (1.0–1.6)b | 53 | 50.0 | 1.1 | (0.7–1.7) | 348 | 53.7 | 1.3 | (1.1–1.7)b | 122 | 50.0 | 1.1 | (0.8–1.4) | |||||
<1.5 | 59 | 5.9 | 48 | 6.1 | 1.2 | (0.8–1.8) | 6 | 5.7 | 1.1 | (0.4–2.7) | 41 | 6.3 | 1.2 | (0.8–1.9) | 13 | 5.3 | 1.0 | (0.5–1.9) | |||||
1.5–4.9 | 121 | 12.2 | 109 | 13.8 | 1.6 | (1.0–1.8) | 12 | 11.3 | 1.1 | (0.5–2.1) | 92 | 14.2 | 1.4 | (1.0–2.0)b | 29 | 11.9 | 1.0 | (0.6–1.6) | |||||
5.0–14.9 | 167 | 16.6 | 133 | 16.9 | 1.2 | (0.9–1.6) | 18 | 17.0 | 1.0 | (0.6–1.9) | 107 | 16.5 | 1.2 | (0.9–1.6) | 43 | 17.6 | 1.1 | (0.7–1.6) | |||||
15.0–29.9 | 91 | 9.2 | 76 | 9.6 | 1.2 | (0.9–1.8) | 12 | 11.3 | 1.4 | (0.7–2.7) | 65 | 10.0 | 1.3 | (0.9–1.9) | 22 | 9.0 | 1.1 | (0.6–1.8) | |||||
≥30.0 | 46 | 4.6 | 53 | 6.7 | 1.7 | (1.1–2.7)b | 5 | 4.7 | 1.2 | (0.5–3.2) | 43 | 6.6 | 1.8 | (1.1–2.8)b | 15 | 6.1 | 1.4 | (0.7–2.7) | |||||
P for trend | 0.705 | 0.544 | 0.998 | 0.702 | |||||||||||||||||||
Former | 77 | 7.7 | 57 | 7.2 | 1.1 | (0.8–1.7) | 8 | 7.5 | 1.1 | (0.5–2.5) | 47 | 7.3 | 1.2 | (0.8–1.8) | 18 | 7.4 | 1.0 | (0.6–1.8) | |||||
Current | 407 | 40.8 | 362 | 45.9 | 1.3 | (1.1–1.6)b | 45 | 42.5 | 1.1 | (0.7–1.8) | 301 | 46.5 | 1.4 | (1.1–1.7)b | 104 | 42.6 | 1.1 | (0.8–1.5) | |||||
<1.5 | 67 | 6.7 | 61 | 7.7 | 1.3 | (0.9–1.8) | 10 | 9.4 | 1.5 | (0.7–3.2) | 50 | 7.7 | 1.3 | (0.9–1.9) | 21 | 8.6 | 1.3 | (0.8–2.2) | |||||
1.5–4.9 | 87 | 8.7 | 76 | 9.6 | 1.3 | (0.9–1.8) | 8 | 7.5 | 1.0 | (0.4–2.1) | 67 | 10.3 | 1.4 | (1.0–2.1)b | 17 | 7.0 | 0.8 | (0.5–1.4) | |||||
5.0–14.9 | 138 | 13.8 | 114 | 14.4 | 1.2 | (0.9–1.7) | 10 | 9.4 | 0.8 | (0.4–1.6) | 94 | 14.5 | 1.3 | (0.9–1.8) | 29 | 11.9 | 0.9 | (0.5–1.4) | |||||
15.0–29.9 | 78 | 7.8 | 61 | 7.7 | 1.2 | (0.8–1.7) | 12 | 11.3 | 1.5 | (0.7–3.0) | 50 | 7.7 | 1.2 | (0.8–1.8) | 22 | 9.0 | 1.2 | (0.7–2.1) | |||||
≥30.0 | 37 | 3.7 | 50 | 6.3 | 1.9 | (1.2–3.1)b | 5 | 4.7 | 1.5 | (0.5–4.0) | 40 | 6.2 | 2.0 | (1.2–3.2)b | 15 | 6.1 | 1.7 | (0.9–3.3) | |||||
P for trend | 0.386 | 0.902 | 0.508 | 0.462 | |||||||||||||||||||
Alcohol use (g/day) | |||||||||||||||||||||||
Never | 514 | 51.5 | 298 | 46.4 | 1.0 | (ref) | 71 | 49.3 | 1.0 | (ref) | 51 | 51.0 | 1.0 | (ref) | |||||||||
Ever | 484 | 48.5 | 344 | 53.6 | 1.3 | (1.1–1.7)b | 73 | 50.7 | 1.1 | (0.7–1.5) | 49 | 49.0 | 1.1 | (0.7–1.7) | |||||||||
<1.5 | 59 | 5.9 | 41 | 6.4 | 1.2 | (0.8–1.9) | 7 | 4.9 | 0.9 | (0.4–2.1) | 6 | 6.0 | 1.1 | (0.5–2.7) | |||||||||
1.5–4.9 | 121 | 12.2 | 90 | 14.0 | 1.4 | (1.0–2.0)b | 19 | 13.2 | 1.0 | (0.6–1.8) | 10 | 10.0 | 0.9 | (0.4–1.9) | |||||||||
5.0–14.9 | 167 | 16.6 | 106 | 16.5 | 1.2 | (0.9–1.6) | 26 | 18.1 | 1.1 | (0.7–1.9) | 17 | 17.0 | 1.0 | (0.5–1.8) | |||||||||
15.0–29.9 | 91 | 9.2 | 64 | 10.0 | 1.3 | (0.9–1.9) | 11 | 7.6 | 0.9 | (0.4–7.8) | 11 | 11.0 | 1.3 | (0.6–2.6) | |||||||||
≥30.0 | 46 | 4.6 | 43 | 6.7 | 1.8 | (1.1–2.8)b | 10 | 6.9 | 1.5 | (0.7–3.3) | 5 | 5.0 | 1.2 | (0.5–3.3) | |||||||||
P for trend | 0.945 | 0.330 | 0.656 | ||||||||||||||||||||
Former | 77 | 7.7 | 46 | 7.2 | 1.2 | (0.8–1.8) | 11 | 7.6 | 1.1 | (0.5–2.2) | 7 | 7.0 | 0.9 | (0.4–2.3) | |||||||||
Current | 407 | 40.8 | 298 | 46.4 | 1.4 | (1.1–1.7)b | 62 | 43.1 | 1.1 | (0.7–1.6) | 42 | 42.0 | 1.1 | (0.7–1.7) | |||||||||
<1.5 | 67 | 6.7 | 50 | 7.8 | 1.3 | (0.9–1.9) | 11 | 7.6 | 1.1 | (0.5–2.3) | 10 | 10.0 | 1.6 | (0.7–3.3) | |||||||||
1.5–4.9 | 87 | 8.7 | 64 | 10.0 | 1.4 | (1.0–2.0)b | 12 | 8.3 | 1.0 | (0.5–1.9) | 5 | 5.0 | 0.6 | (0.2–1.6) | |||||||||
5.0–14.9 | 138 | 13.8 | 94 | 14.6 | 1.3 | (0.9–1.8) | 19 | 13.2 | 0.9 | (0.5–1.7) | 10 | 10.0 | 0.8 | (0.4–1.6) | |||||||||
15.0–29.9 | 78 | 7.8 | 50 | 7.8 | 1.2 | (0.8–1.8) | 10 | 6.9 | 1.0 | (0.5–2.1) | 12 | 12.0 | 1.5 | (0.7–3.1) | |||||||||
≥30.0 | 37 | 3.7 | 40 | 6.2 | 2.0 | (1.2–3.3)b | 10 | 6.9 | 1.8 | (0.8–4.0) | 5 | 5.0 | 1.5 | (0.6–4.1) | |||||||||
P for trend | 0.439 | 0.548 | 0.367 |