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Table 2

Relationship between alcohol use and risk of overall and specific histologic types of breast cancer

FactorControls n = 998Overall n = 967ORa95% CIDuctal n = 651OR95% CILobular n = 195OR95% CI
N%N%N%N%
Alcohol use (g/day)               
 Neverb 514 51.5 459 47.5 1.0 (ref) 319 49.0 1.0 (ref) 77 39.5 1.0 (ref) 
 Ever 484 48.5 508 52.5 1.3 (1.0–1.5)c 332 51.0 1.2 (0.9–1.4) 118 60.5 1.8 (1.3–2.5)c 
  <1.5 59 5.9 60 6.2 1.2 (0.8–1.8) 41 6.3 1.2 (0.8–1.9) 14 7.2 1.5 (0.8–3.0) 
  1.5–4.9 121 12.2 128 13.2 1.6 (0.9–1.7) 85 13.0 1.2 (0.9–1.7) 31 15.9 1.9 (1.2–3.1)c 
  5.0–14.9 167 16.6 161 16.6 1.1 (0.9–1.5) 100 15.4 1.0 (0.7–1.3) 36 18.5 1.6 (1.0–2.5)c 
  15.0–29.9 91 9.2 96 9.9 1.3 (0.9–1.7) 68 10.4 1.2 (0.9–1.8) 20 10.3 1.7 (1.0–2.9) 
  ≥30.0 46 4.6 63 6.5 1.7 (1.1–2.6)c 38 5.8 1.5 (0.9–2.3) 17 8.7 2.6 (1.3–4.9)c 
  P for trendd     0.673    0.931    0.614  
 Formerb 77 7.7 70 7.2 1.1 (0.8–1.7) 43 6.6 1.0 (0.6–1.5) 16 8.2 1.5 (0.8–2.8) 
 Currentb 407 40.8 438 45.3 1.3 (1.0–1.6)c 289 44.4 1.2 (1.0–1.5) 102 52.3 1.8 (1.3–2.6)c 
  <1.5 67 6.7 79 8.2 1.3 (0.9–1.9) 52 8.0 1.2 (0.8–1.9) 20 10.3 2.1 (1.2–3.7)c 
  1.5–4.9 87 8.7 90 9.3 1.2 (0.9–1.7) 56 8.6 1.1 (0.7–1.6) 23 11.8 2.1 (1.2–3.5)c 
  5.0–14.9 138 13.8 133 13.8 1.1 (0.9–1.5) 91 14.0 1.1 (0.8–1.5) 27 13.8 1.4 (0.9–2.4) 
  15.0–29.9 78 7.8 78 8.1 1.2 (0.8–1.7) 56 8.6 1.2 (0.8–1.8) 14 7.2 1.4 (0.8–2.7) 
  ≥30.0 37 3.7 58 6.0 1.8 (1.2–2.9)c 34 5.2 1.5 (0.9–2.6) 18 9.2 3.3 (1.7–6.4)c 
  p for trendd     0.419    0.638    0.453  
FactorControls n = 998Overall n = 967ORa95% CIDuctal n = 651OR95% CILobular n = 195OR95% CI
N%N%N%N%
Alcohol use (g/day)               
 Neverb 514 51.5 459 47.5 1.0 (ref) 319 49.0 1.0 (ref) 77 39.5 1.0 (ref) 
 Ever 484 48.5 508 52.5 1.3 (1.0–1.5)c 332 51.0 1.2 (0.9–1.4) 118 60.5 1.8 (1.3–2.5)c 
  <1.5 59 5.9 60 6.2 1.2 (0.8–1.8) 41 6.3 1.2 (0.8–1.9) 14 7.2 1.5 (0.8–3.0) 
  1.5–4.9 121 12.2 128 13.2 1.6 (0.9–1.7) 85 13.0 1.2 (0.9–1.7) 31 15.9 1.9 (1.2–3.1)c 
  5.0–14.9 167 16.6 161 16.6 1.1 (0.9–1.5) 100 15.4 1.0 (0.7–1.3) 36 18.5 1.6 (1.0–2.5)c 
  15.0–29.9 91 9.2 96 9.9 1.3 (0.9–1.7) 68 10.4 1.2 (0.9–1.8) 20 10.3 1.7 (1.0–2.9) 
  ≥30.0 46 4.6 63 6.5 1.7 (1.1–2.6)c 38 5.8 1.5 (0.9–2.3) 17 8.7 2.6 (1.3–4.9)c 
  P for trendd     0.673    0.931    0.614  
 Formerb 77 7.7 70 7.2 1.1 (0.8–1.7) 43 6.6 1.0 (0.6–1.5) 16 8.2 1.5 (0.8–2.8) 
 Currentb 407 40.8 438 45.3 1.3 (1.0–1.6)c 289 44.4 1.2 (1.0–1.5) 102 52.3 1.8 (1.3–2.6)c 
  <1.5 67 6.7 79 8.2 1.3 (0.9–1.9) 52 8.0 1.2 (0.8–1.9) 20 10.3 2.1 (1.2–3.7)c 
  1.5–4.9 87 8.7 90 9.3 1.2 (0.9–1.7) 56 8.6 1.1 (0.7–1.6) 23 11.8 2.1 (1.2–3.5)c 
  5.0–14.9 138 13.8 133 13.8 1.1 (0.9–1.5) 91 14.0 1.1 (0.8–1.5) 27 13.8 1.4 (0.9–2.4) 
  15.0–29.9 78 7.8 78 8.1 1.2 (0.8–1.7) 56 8.6 1.2 (0.8–1.8) 14 7.2 1.4 (0.8–2.7) 
  ≥30.0 37 3.7 58 6.0 1.8 (1.2–2.9)c 34 5.2 1.5 (0.9–2.6) 18 9.2 3.3 (1.7–6.4)c 
  p for trendd     0.419    0.638    0.453  
a

All odds ratios (ORs) are adjusted for age (continuous), family history of breast cancer (yes/no), and body mass index (quartiles).

b

Women who drank <12 beverages containing alcohol during the past 20 years, or who did not consume at least one beverage containing alcohol a month for 6 months during the past 20 years, were classified as never-users of alcohol. Former users were defined as ever-users of alcohol who reported no alcohol consumption during the year prior to their reference date. Current users were defined as users of alcohol who reported using alcohol during the year prior to their reference date.

c

P < 0.05.

d

P for trend were evaluated by treating alcohol use (g/day) as a continuous variable and excluding subjects who were never-users of alcohol.

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