Distribution of demographic and known risk factors for breast cancer among 1007 controls, 975 breast cancer cases, 656 ductal cases, 196 lobular cases, 796 ER+ cases, and 107 ER− cases
Characteristic . | Controls (n = 1007) . | . | All cases (n = 975) . | . | Ductal (n = 656) . | . | Lobular (n = 196) . | . | ER+ (n = 796) . | . | ER− (n = 107) . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | ||||||
Reference age | ||||||||||||||||||
65–69 | 330 | 32.8 | 300 | 30.8 | 204 | 31.1 | 58 | 29.6 | 240 | 30.2 | 41 | 38.3 | ||||||
70–74 | 381 | 37.8 | 381 | 39.1 | 252 | 38.4 | 85 | 43.4 | 319 | 40.1 | 33 | 30.8 | ||||||
75–79 | 296 | 29.4 | 294 | 30.2 | 200 | 30.5 | 53 | 27.0 | 237 | 29.8 | 33 | 30.8 | ||||||
Race | ||||||||||||||||||
White | 925 | 91.9 | 929 | 95.3 | 623 | 95 | 188 | 95.9 | 759 | 95.4 | 104 | 97.2 | ||||||
Black | 37 | 3.7 | 16 | 1.6 | 11 | 1.7 | 3 | 1.5 | 13 | 1.6 | 2 | 1.9 | ||||||
Asian/Pacific Islander | 29 | 2.9 | 19 | 1.9 | 18 | 2.7 | 1 | 0.5 | 17 | 2.1 | 0 | 0.0 | ||||||
Other/unknown | 16 | 1.6 | 11 | 1.1 | 4 | 0.6 | 4 | 2.0 | 7 | 0.9 | 1 | 0.9 | ||||||
Income | ||||||||||||||||||
<$15,000 | 191 | 21.7 | 177 | 21.3 | 124 | 22.1 | 30 | 17.9 | 145 | 21.3 | 22 | 24.4 | ||||||
$15–25,000 | 214 | 24.3 | 198 | 23.9 | 139 | 24.8 | 39 | 23.2 | 166 | 24.4 | 20 | 22.2 | ||||||
$25–50,000 | 296 | 33.6 | 296 | 35.7 | 204 | 36.4 | 60 | 35.7 | 239 | 35.1 | 36 | 40.0 | ||||||
>$50,000 | 180 | 20.4 | 159 | 19.2 | 94 | 16.8 | 39 | 23.2 | 131 | 19.2 | 12 | 13.3 | ||||||
Missing | 126 | 145 | 95 | 28 | 115 | 17 | ||||||||||||
Parity | ||||||||||||||||||
Nulliparous | 94 | 9.3 | 88 | 9.0 | 57 | 8.7 | 20 | 10.2 | 71 | 8.9 | 11 | 10.3 | ||||||
Parous | 913 | 90.7 | 887 | 91.0 | 599 | 91.3 | 176 | 89.8 | 725 | 91.1 | 96 | 89.7 | ||||||
Type of menopause | ||||||||||||||||||
Natural | 607 | 61.6 | 583 | 61.4 | 400 | 62.8 | 113 | 59.8 | 483 | 62.6 | 58 | 55.2 | ||||||
Induced | 148 | 15.0 | 129 | 13.6 | 78 | 12.2 | 29 | 15.3 | 96 | 12.4 | 18 | 17.1 | ||||||
Simple hysterectomy | 231 | 21.6 | 237 | 25.0 | 159 | 25.0 | 47 | 24.9 | 193 | 25.0 | 29 | 27.6 | ||||||
Missing | 21 | 26 | 19 | 7 | 24 | 2 | ||||||||||||
First-degree family history of breast cancer | ||||||||||||||||||
No | 771 | 82.9 | 703 | 77.2 | 469 | 77.1 | 146 | 78.5 | 564 | 76.0 | 83 | 82.2 | ||||||
Yes | 159 | 17.1 | 208 | 22.8 | 139 | 22.9 | 40 | 21.5 | 178 | 24.0 | 18 | 17.8 | ||||||
Missing | 77 | 64 | 48 | 10 | 54 | 6 | ||||||||||||
BMI, quartiles | ||||||||||||||||||
≤23.32 | 261 | 27.1 | 209 | 22.3 | 139 | 22.0 | 51 | 27.1 | 166 | 21.6 | 25 | 24.3 | ||||||
23.33–26.20 | 241 | 25.0 | 240 | 25.6 | 164 | 25.9 | 43 | 22.9 | 196 | 25.5 | 28 | 27.2 | ||||||
26.21–30.11 | 230 | 23.9 | 245 | 26.1 | 162 | 25.6 | 52 | 27.7 | 200 | 26.0 | 26 | 25.2 | ||||||
≥30.12 | 231 | 24.0 | 245 | 26.1 | 168 | 26.5 | 42 | 22.3 | 206 | 26.8 | 24 | 23.3 | ||||||
Missing | 44 | 36 | 23 | 8 | 28 | 4 | ||||||||||||
Smoking status | ||||||||||||||||||
Never | 523 | 51.9 | 450 | 46.2 | 301 | 45.9 | 89 | 45.4 | 373 | 46.9 | 48 | 44.9 | ||||||
Former | 369 | 36.6 | 396 | 40.6 | 269 | 41.0 | 79 | 40.3 | 321 | 40.3 | 46 | 43.0 | ||||||
Current | 115 | 11.4 | 129 | 13.2 | 86 | 13.1 | 28 | 14.3 | 102 | 12.8 | 13 | 12.1 | ||||||
Smoking duration, pack years | ||||||||||||||||||
0 | 523 | 52.0 | 450 | 46.3 | 301 | 46.1 | 89 | 45.4 | 373 | 47.0 | 48 | 45.3 | ||||||
<10 | 107 | 10.6 | 89 | 9.2 | 56 | 8.6 | 21 | 10.7 | 70 | 8.8 | 10 | 9.4 | ||||||
10–29 | 143 | 14.2 | 166 | 17.1 | 119 | 18.2 | 30 | 15.3 | 136 | 17.1 | 18 | 17.0 | ||||||
≥30 | 233 | 23.2 | 267 | 27.5 | 177 | 27.1 | 56 | 28.6 | 215 | 27.1 | 30 | 29.3 | ||||||
Missing | 1 | 3 | 3 | 0 | 2 | 1 | ||||||||||||
Ever-use of HRT | ||||||||||||||||||
Never/<6 months | 413 | 41.1 | 352 | 36.3 | 243 | 37.3 | 59 | 30.1 | 285 | 35.9 | 40 | 38.1 | ||||||
6 months-5 years | 156 | 15.5 | 119 | 12.3 | 87 | 13.4 | 22 | 11.2 | 97 | 12.2 | 16 | 15.2 | ||||||
≥5 years | 435 | 43.3 | 499 | 51.4 | 321 | 49.3 | 115 | 58.7 | 411 | 51.8 | 49 | 46.7 | ||||||
Missing | 3 | 5 | 5 | 0 | 3 | 2 |
Characteristic . | Controls (n = 1007) . | . | All cases (n = 975) . | . | Ductal (n = 656) . | . | Lobular (n = 196) . | . | ER+ (n = 796) . | . | ER− (n = 107) . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | ||||||
Reference age | ||||||||||||||||||
65–69 | 330 | 32.8 | 300 | 30.8 | 204 | 31.1 | 58 | 29.6 | 240 | 30.2 | 41 | 38.3 | ||||||
70–74 | 381 | 37.8 | 381 | 39.1 | 252 | 38.4 | 85 | 43.4 | 319 | 40.1 | 33 | 30.8 | ||||||
75–79 | 296 | 29.4 | 294 | 30.2 | 200 | 30.5 | 53 | 27.0 | 237 | 29.8 | 33 | 30.8 | ||||||
Race | ||||||||||||||||||
White | 925 | 91.9 | 929 | 95.3 | 623 | 95 | 188 | 95.9 | 759 | 95.4 | 104 | 97.2 | ||||||
Black | 37 | 3.7 | 16 | 1.6 | 11 | 1.7 | 3 | 1.5 | 13 | 1.6 | 2 | 1.9 | ||||||
Asian/Pacific Islander | 29 | 2.9 | 19 | 1.9 | 18 | 2.7 | 1 | 0.5 | 17 | 2.1 | 0 | 0.0 | ||||||
Other/unknown | 16 | 1.6 | 11 | 1.1 | 4 | 0.6 | 4 | 2.0 | 7 | 0.9 | 1 | 0.9 | ||||||
Income | ||||||||||||||||||
<$15,000 | 191 | 21.7 | 177 | 21.3 | 124 | 22.1 | 30 | 17.9 | 145 | 21.3 | 22 | 24.4 | ||||||
$15–25,000 | 214 | 24.3 | 198 | 23.9 | 139 | 24.8 | 39 | 23.2 | 166 | 24.4 | 20 | 22.2 | ||||||
$25–50,000 | 296 | 33.6 | 296 | 35.7 | 204 | 36.4 | 60 | 35.7 | 239 | 35.1 | 36 | 40.0 | ||||||
>$50,000 | 180 | 20.4 | 159 | 19.2 | 94 | 16.8 | 39 | 23.2 | 131 | 19.2 | 12 | 13.3 | ||||||
Missing | 126 | 145 | 95 | 28 | 115 | 17 | ||||||||||||
Parity | ||||||||||||||||||
Nulliparous | 94 | 9.3 | 88 | 9.0 | 57 | 8.7 | 20 | 10.2 | 71 | 8.9 | 11 | 10.3 | ||||||
Parous | 913 | 90.7 | 887 | 91.0 | 599 | 91.3 | 176 | 89.8 | 725 | 91.1 | 96 | 89.7 | ||||||
Type of menopause | ||||||||||||||||||
Natural | 607 | 61.6 | 583 | 61.4 | 400 | 62.8 | 113 | 59.8 | 483 | 62.6 | 58 | 55.2 | ||||||
Induced | 148 | 15.0 | 129 | 13.6 | 78 | 12.2 | 29 | 15.3 | 96 | 12.4 | 18 | 17.1 | ||||||
Simple hysterectomy | 231 | 21.6 | 237 | 25.0 | 159 | 25.0 | 47 | 24.9 | 193 | 25.0 | 29 | 27.6 | ||||||
Missing | 21 | 26 | 19 | 7 | 24 | 2 | ||||||||||||
First-degree family history of breast cancer | ||||||||||||||||||
No | 771 | 82.9 | 703 | 77.2 | 469 | 77.1 | 146 | 78.5 | 564 | 76.0 | 83 | 82.2 | ||||||
Yes | 159 | 17.1 | 208 | 22.8 | 139 | 22.9 | 40 | 21.5 | 178 | 24.0 | 18 | 17.8 | ||||||
Missing | 77 | 64 | 48 | 10 | 54 | 6 | ||||||||||||
BMI, quartiles | ||||||||||||||||||
≤23.32 | 261 | 27.1 | 209 | 22.3 | 139 | 22.0 | 51 | 27.1 | 166 | 21.6 | 25 | 24.3 | ||||||
23.33–26.20 | 241 | 25.0 | 240 | 25.6 | 164 | 25.9 | 43 | 22.9 | 196 | 25.5 | 28 | 27.2 | ||||||
26.21–30.11 | 230 | 23.9 | 245 | 26.1 | 162 | 25.6 | 52 | 27.7 | 200 | 26.0 | 26 | 25.2 | ||||||
≥30.12 | 231 | 24.0 | 245 | 26.1 | 168 | 26.5 | 42 | 22.3 | 206 | 26.8 | 24 | 23.3 | ||||||
Missing | 44 | 36 | 23 | 8 | 28 | 4 | ||||||||||||
Smoking status | ||||||||||||||||||
Never | 523 | 51.9 | 450 | 46.2 | 301 | 45.9 | 89 | 45.4 | 373 | 46.9 | 48 | 44.9 | ||||||
Former | 369 | 36.6 | 396 | 40.6 | 269 | 41.0 | 79 | 40.3 | 321 | 40.3 | 46 | 43.0 | ||||||
Current | 115 | 11.4 | 129 | 13.2 | 86 | 13.1 | 28 | 14.3 | 102 | 12.8 | 13 | 12.1 | ||||||
Smoking duration, pack years | ||||||||||||||||||
0 | 523 | 52.0 | 450 | 46.3 | 301 | 46.1 | 89 | 45.4 | 373 | 47.0 | 48 | 45.3 | ||||||
<10 | 107 | 10.6 | 89 | 9.2 | 56 | 8.6 | 21 | 10.7 | 70 | 8.8 | 10 | 9.4 | ||||||
10–29 | 143 | 14.2 | 166 | 17.1 | 119 | 18.2 | 30 | 15.3 | 136 | 17.1 | 18 | 17.0 | ||||||
≥30 | 233 | 23.2 | 267 | 27.5 | 177 | 27.1 | 56 | 28.6 | 215 | 27.1 | 30 | 29.3 | ||||||
Missing | 1 | 3 | 3 | 0 | 2 | 1 | ||||||||||||
Ever-use of HRT | ||||||||||||||||||
Never/<6 months | 413 | 41.1 | 352 | 36.3 | 243 | 37.3 | 59 | 30.1 | 285 | 35.9 | 40 | 38.1 | ||||||
6 months-5 years | 156 | 15.5 | 119 | 12.3 | 87 | 13.4 | 22 | 11.2 | 97 | 12.2 | 16 | 15.2 | ||||||
≥5 years | 435 | 43.3 | 499 | 51.4 | 321 | 49.3 | 115 | 58.7 | 411 | 51.8 | 49 | 46.7 | ||||||
Missing | 3 | 5 | 5 | 0 | 3 | 2 |