American Association for Cancer Research

Table 4

Relationships of alcohol, folate and their combinations to colorectal adenoma risk stratified by ADH₃ genotype in the HPFS (1986–1995)

ADH ₃	≤5	Alcohol (g/day) 5–30	>30
1–1 OR (95% CI)^a	1.0 (ref)	1.33 (0.85–2.07)	1.27 (0.63–2.53)
	[55; 127]^b	[72; 116]	[18; 30]
1–2 OR (95% CI)^a	0.99 (0.64–1.54)	1.02 (0.67–1.57)	1.83 (1.03–3.26)
	[65; 149]	[76; 162]	[34; 39]
2–2 OR (95% CI)^a	1.06 (0.55–2.02)	0.83 (0.45–1.53)	2.94 (1.24–6.92)
	[18; 40]	[21; 53]	[16; 11]
		P for interaction = 0.17

ADH ₃	≤5	Alcohol (g/day) 5–30	>30
1–1 OR (95% CI)^a	1.0 (ref)	1.33 (0.85–2.07)	1.27 (0.63–2.53)
	[55; 127]^b	[72; 116]	[18; 30]
1–2 OR (95% CI)^a	0.99 (0.64–1.54)	1.02 (0.67–1.57)	1.83 (1.03–3.26)
	[65; 149]	[76; 162]	[34; 39]
2–2 OR (95% CI)^a	1.06 (0.55–2.02)	0.83 (0.45–1.53)	2.94 (1.24–6.92)
	[18; 40]	[21; 53]	[16; 11]
		P for interaction = 0.17

ADH ₃	<338	Folate (μg/day) 338–496	≥497
1–1 OR (95% CI)^a	1.0	1.51 (0.90–2.52)	1.32 (0.78–2.23)
	[41; 88]	[56; 91]	[48; 94]
1–2 OR (95% CI)^a	1.04 (0.63–1.70)	1.18 (0.71–1.95)	1.34 (0.81–2.21)
	[61; 131]	[55; 114]	[59; 104]
2–2 OR (95% CI)^a	1.97 (0.97–4.02)	0.93 (0.45–1.95)	1.01 (0.52–1.96)
	[21; 24]	[14; 36]	[20; 44]
		P for interaction = 0.55

ADH ₃	<338	Folate (μg/day) 338–496	≥497
1–1 OR (95% CI)^a	1.0	1.51 (0.90–2.52)	1.32 (0.78–2.23)
	[41; 88]	[56; 91]	[48; 94]
1–2 OR (95% CI)^a	1.04 (0.63–1.70)	1.18 (0.71–1.95)	1.34 (0.81–2.21)
	[61; 131]	[55; 114]	[59; 104]
2–2 OR (95% CI)^a	1.97 (0.97–4.02)	0.93 (0.45–1.95)	1.01 (0.52–1.96)
	[21; 24]	[14; 36]	[20; 44]
		P for interaction = 0.55

ADH ₃	Alcohol/Folate
ADH ₃		Alcohol <20 g/day or Folate ≥338 μg/day	Alcohol ≥20 g/day and Folate <338 μg/day
1–1 OR (95% CI)^a	1.0	0.65 (0.28–1.49)
	[136; 251]	[9; 22]
1–2 OR (95% CI)^a	0.85 (0.64–1.13)	1.75 (0.93–3.30)
	[152; 326]	[23; 23]
2–2 OR (95% CI)^a	0.79 (0.52–1.19)	17.1 (2.13–137.0)
	[45; 103]	[10; 1]
	P for interaction = 0.006

ADH ₃	Alcohol/Folate
ADH ₃		Alcohol <20 g/day or Folate ≥338 μg/day	Alcohol ≥20 g/day and Folate <338 μg/day
1–1 OR (95% CI)^a	1.0	0.65 (0.28–1.49)
	[136; 251]	[9; 22]
1–2 OR (95% CI)^a	0.85 (0.64–1.13)	1.75 (0.93–3.30)
	[152; 326]	[23; 23]
2–2 OR (95% CI)^a	0.79 (0.52–1.19)	17.1 (2.13–137.0)
	[45; 103]	[10; 1]
	P for interaction = 0.006

OR and 95% CI controlling for matching variables (age, previous endoscopy, year of endoscopy), and smoking history, aspirin use, BMI, physical activity, and intakes of red meat and alcohol or folate.

[cases; controls].

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