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Table 4

Relationships of alcohol, folate and their combinations to colorectal adenoma risk stratified by ADH3 genotype in the HPFS (1986–1995)

ADH                  3≤5Alcohol (g/day) 5–30>30
1–1 OR (95% CI)a 1.0 (ref) 1.33 (0.85–2.07) 1.27 (0.63–2.53) 
 [55; 127]b [72; 116] [18; 30] 
1–2 OR (95% CI)a 0.99 (0.64–1.54) 1.02 (0.67–1.57) 1.83 (1.03–3.26) 
 [65; 149] [76; 162] [34; 39] 
2–2 OR (95% CI)a 1.06 (0.55–2.02) 0.83 (0.45–1.53) 2.94 (1.24–6.92) 
 [18; 40] [21; 53] [16; 11] 
  P for interaction = 0.17  
ADH                  3≤5Alcohol (g/day) 5–30>30
1–1 OR (95% CI)a 1.0 (ref) 1.33 (0.85–2.07) 1.27 (0.63–2.53) 
 [55; 127]b [72; 116] [18; 30] 
1–2 OR (95% CI)a 0.99 (0.64–1.54) 1.02 (0.67–1.57) 1.83 (1.03–3.26) 
 [65; 149] [76; 162] [34; 39] 
2–2 OR (95% CI)a 1.06 (0.55–2.02) 0.83 (0.45–1.53) 2.94 (1.24–6.92) 
 [18; 40] [21; 53] [16; 11] 
  P for interaction = 0.17  
ADH                  3<338Folate (μg/day) 338–496≥497
1–1 OR (95% CI)a 1.0 1.51 (0.90–2.52) 1.32 (0.78–2.23) 
 [41; 88] [56; 91] [48; 94] 
1–2 OR (95% CI)a 1.04 (0.63–1.70) 1.18 (0.71–1.95) 1.34 (0.81–2.21) 
 [61; 131] [55; 114] [59; 104] 
2–2 OR (95% CI)a 1.97 (0.97–4.02) 0.93 (0.45–1.95) 1.01 (0.52–1.96) 
 [21; 24] [14; 36] [20; 44] 
  P for interaction = 0.55  
ADH                  3<338Folate (μg/day) 338–496≥497
1–1 OR (95% CI)a 1.0 1.51 (0.90–2.52) 1.32 (0.78–2.23) 
 [41; 88] [56; 91] [48; 94] 
1–2 OR (95% CI)a 1.04 (0.63–1.70) 1.18 (0.71–1.95) 1.34 (0.81–2.21) 
 [61; 131] [55; 114] [59; 104] 
2–2 OR (95% CI)a 1.97 (0.97–4.02) 0.93 (0.45–1.95) 1.01 (0.52–1.96) 
 [21; 24] [14; 36] [20; 44] 
  P for interaction = 0.55  
ADH                  3Alcohol/Folate
Alcohol <20 g/day or Folate ≥338 μg/dayAlcohol ≥20 g/day and Folate <338 μg/day
1–1 OR (95% CI)a 1.0 0.65 (0.28–1.49) 
 [136; 251] [9; 22] 
1–2 OR (95% CI)a 0.85 (0.64–1.13) 1.75 (0.93–3.30) 
 [152; 326] [23; 23] 
2–2 OR (95% CI)a 0.79 (0.52–1.19) 17.1 (2.13–137.0) 
 [45; 103] [10; 1] 
 P for interaction = 0.006  
ADH                  3Alcohol/Folate
Alcohol <20 g/day or Folate ≥338 μg/dayAlcohol ≥20 g/day and Folate <338 μg/day
1–1 OR (95% CI)a 1.0 0.65 (0.28–1.49) 
 [136; 251] [9; 22] 
1–2 OR (95% CI)a 0.85 (0.64–1.13) 1.75 (0.93–3.30) 
 [152; 326] [23; 23] 
2–2 OR (95% CI)a 0.79 (0.52–1.19) 17.1 (2.13–137.0) 
 [45; 103] [10; 1] 
 P for interaction = 0.006  
a

OR and 95% CI controlling for matching variables (age, previous endoscopy, year of endoscopy), and smoking history, aspirin use, BMI, physical activity, and intakes of red meat and alcohol or folate.

b

[cases; controls].

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