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Table 3

Relationships of alcohol and folate intake to colorectal adenoma risk stratified by MTHFR 1298 genotype in the HPFS (1986–1995)

MTHFR 1298≤5Alcohol (g/day) 5–30>30
1298 AA OR (95% CI)a 1.0 (ref) 0.99 (0.66–1.48) 2.36 (1.37–4.07) 
 [66; 155]b [78; 175] [42; 39] 
1298 AC OR (95% CI)a 1.07 (0.72–1.66) 1.33 (0.88–2.03) 1.46 (0.80–2.69) 
 [64; 137] [76; 125] [25; 37] 
1298 CC OR (95% CI)a 0.98 (0.42–2.28) 0.94 (0.47–1.91) 0.43 (0.05–4.08) 
 [9; 22] [14; 31] [1; 4] 
  P for interaction = 0.82  
MTHFR 1298≤5Alcohol (g/day) 5–30>30
1298 AA OR (95% CI)a 1.0 (ref) 0.99 (0.66–1.48) 2.36 (1.37–4.07) 
 [66; 155]b [78; 175] [42; 39] 
1298 AC OR (95% CI)a 1.07 (0.72–1.66) 1.33 (0.88–2.03) 1.46 (0.80–2.69) 
 [64; 137] [76; 125] [25; 37] 
1298 CC OR (95% CI)a 0.98 (0.42–2.28) 0.94 (0.47–1.91) 0.43 (0.05–4.08) 
 [9; 22] [14; 31] [1; 4] 
  P for interaction = 0.82  
MTHFR 1298<338Folate (μg/day) 338–496≥497
1298 AA OR (95% CI)a 1.0 1.43 (0.92–2.23) 1.37 (0.87–2.15) 
 [55; 128] [68; 122] [63; 119] 
1298 AC OR (95% CI)a 1.35 (0.83–2.16) 1.40 (0.87–2.25) 1.35 (0.85–2.15) 
 [56; 97] [52; 97] [57; 105] 
1298 CC OR (95% CI)a 1.41 (0.61–3.27) 0.82 (0.32–2.07) 0.93 (0.34–2.55) 
 [11; 18] [7; 22] [6; 17] 
  P for interaction = 0.18  
MTHFR 1298<338Folate (μg/day) 338–496≥497
1298 AA OR (95% CI)a 1.0 1.43 (0.92–2.23) 1.37 (0.87–2.15) 
 [55; 128] [68; 122] [63; 119] 
1298 AC OR (95% CI)a 1.35 (0.83–2.16) 1.40 (0.87–2.25) 1.35 (0.85–2.15) 
 [56; 97] [52; 97] [57; 105] 
1298 CC OR (95% CI)a 1.41 (0.61–3.27) 0.82 (0.32–2.07) 0.93 (0.34–2.55) 
 [11; 18] [7; 22] [6; 17] 
  P for interaction = 0.18  
a

OR and 95% CI controlling for matching variables (age, previous endoscopy, year of endoscopy), and smoking history, aspirin use, BMI, physical activity, and intakes of red meat and alcohol or folate.

b

[cases; controls].

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