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Table 2

Relationships of alcohol, folate and their combinations to colorectal adenoma risk stratified by MTHFR 677 genotype in the HPFS (1986–1995)

MTHFR 677≤5Alcohol (g/day) 5–30>30
CC/CT OR (95% CI)a 1.0 (ref) 1.11 (0.82–1.49) 1.50 (0.97–2.32) 
 [123; 272]b [149; 280] [53; 72] 
TT OR (95% CI)a 0.79 (0.42–1.49) 0.85 (0.48–1.51) 3.52 (1.41–8.78) 
 [15; 43] [20; 50] [14; 8] 
  P for interaction = 0.09  
MTHFR 677≤5Alcohol (g/day) 5–30>30
CC/CT OR (95% CI)a 1.0 (ref) 1.11 (0.82–1.49) 1.50 (0.97–2.32) 
 [123; 272]b [149; 280] [53; 72] 
TT OR (95% CI)a 0.79 (0.42–1.49) 0.85 (0.48–1.51) 3.52 (1.41–8.78) 
 [15; 43] [20; 50] [14; 8] 
  P for interaction = 0.09  
MTHFR 677<338Folate (μg/day) 338–496≥497
CC/CT OR (95% CI)a 1.0 1.14 (0.81–1.61) 1.09 (0.77–1.54) 
 [107; 208] [108; 201] [110; 215] 
TT OR (95% CI)a 0.89 (0.46–1.70) 1.01 (0.54–1.88) 1.16 (0.58–2.33) 
 [16; 35] [18; 40] [15; 26] 
  P for interaction = 0.48  
MTHFR 677<338Folate (μg/day) 338–496≥497
CC/CT OR (95% CI)a 1.0 1.14 (0.81–1.61) 1.09 (0.77–1.54) 
 [107; 208] [108; 201] [110; 215] 
TT OR (95% CI)a 0.89 (0.46–1.70) 1.01 (0.54–1.88) 1.16 (0.58–2.33) 
 [16; 35] [18; 40] [15; 26] 
  P for interaction = 0.48  
MTHFR 677Alcohol ≤5 g/day Folate >497 μg/dayAlcohol/folate MiddleAlcohol ≥20 g/day Folate <338 μg/day
CC/CT OR (95% CI)a 1.0 0.84 (0.57–1.24) 1.40 (0.77–2.54) 
 [48; 92] [242; 491] [35; 41] 
TT OR (95% CI)a 0.45 (0.12–1.69) 0.82 (0.49–1.40) 2.08 (0.61–7.07) 
 [3; 13] [39; 83] [7; 5] 
  P for interaction = 0.20  
MTHFR 677Alcohol ≤5 g/day Folate >497 μg/dayAlcohol/folate MiddleAlcohol ≥20 g/day Folate <338 μg/day
CC/CT OR (95% CI)a 1.0 0.84 (0.57–1.24) 1.40 (0.77–2.54) 
 [48; 92] [242; 491] [35; 41] 
TT OR (95% CI)a 0.45 (0.12–1.69) 0.82 (0.49–1.40) 2.08 (0.61–7.07) 
 [3; 13] [39; 83] [7; 5] 
  P for interaction = 0.20  
a

OR and 95% CI controlling for matching variables (age, previous endoscopy, year of endoscopy), and smoking history, aspirin use, BMI, physical activity, and intakes of red meat and alcohol or folate.

b

[cases; controls].

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