American Association for Cancer Research

Table 2

Relationships of alcohol, folate and their combinations to colorectal adenoma risk stratified by MTHFR 677 genotype in the HPFS (1986–1995)

MTHFR 677	≤5	Alcohol (g/day) 5–30	>30
CC/CT OR (95% CI)^a	1.0 (ref)	1.11 (0.82–1.49)	1.50 (0.97–2.32)
	[123; 272]^b	[149; 280]	[53; 72]
TT OR (95% CI)^a	0.79 (0.42–1.49)	0.85 (0.48–1.51)	3.52 (1.41–8.78)
	[15; 43]	[20; 50]	[14; 8]
		P for interaction = 0.09

MTHFR 677	≤5	Alcohol (g/day) 5–30	>30
CC/CT OR (95% CI)^a	1.0 (ref)	1.11 (0.82–1.49)	1.50 (0.97–2.32)
	[123; 272]^b	[149; 280]	[53; 72]
TT OR (95% CI)^a	0.79 (0.42–1.49)	0.85 (0.48–1.51)	3.52 (1.41–8.78)
	[15; 43]	[20; 50]	[14; 8]
		P for interaction = 0.09

MTHFR 677	<338	Folate (μg/day) 338–496	≥497
CC/CT OR (95% CI)^a	1.0	1.14 (0.81–1.61)	1.09 (0.77–1.54)
	[107; 208]	[108; 201]	[110; 215]
TT OR (95% CI)^a	0.89 (0.46–1.70)	1.01 (0.54–1.88)	1.16 (0.58–2.33)
	[16; 35]	[18; 40]	[15; 26]
		P for interaction = 0.48

MTHFR 677	<338	Folate (μg/day) 338–496	≥497
CC/CT OR (95% CI)^a	1.0	1.14 (0.81–1.61)	1.09 (0.77–1.54)
	[107; 208]	[108; 201]	[110; 215]
TT OR (95% CI)^a	0.89 (0.46–1.70)	1.01 (0.54–1.88)	1.16 (0.58–2.33)
	[16; 35]	[18; 40]	[15; 26]
		P for interaction = 0.48

MTHFR 677	Alcohol ≤5 g/day Folate >497 μg/day	Alcohol/folate Middle	Alcohol ≥20 g/day Folate <338 μg/day
CC/CT OR (95% CI)^a	1.0	0.84 (0.57–1.24)	1.40 (0.77–2.54)
	[48; 92]	[242; 491]	[35; 41]
TT OR (95% CI)^a	0.45 (0.12–1.69)	0.82 (0.49–1.40)	2.08 (0.61–7.07)
	[3; 13]	[39; 83]	[7; 5]
		P for interaction = 0.20

MTHFR 677	Alcohol ≤5 g/day Folate >497 μg/day	Alcohol/folate Middle	Alcohol ≥20 g/day Folate <338 μg/day
CC/CT OR (95% CI)^a	1.0	0.84 (0.57–1.24)	1.40 (0.77–2.54)
	[48; 92]	[242; 491]	[35; 41]
TT OR (95% CI)^a	0.45 (0.12–1.69)	0.82 (0.49–1.40)	2.08 (0.61–7.07)
	[3; 13]	[39; 83]	[7; 5]
		P for interaction = 0.20

OR and 95% CI controlling for matching variables (age, previous endoscopy, year of endoscopy), and smoking history, aspirin use, BMI, physical activity, and intakes of red meat and alcohol or folate.

[cases; controls].

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