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Table 1

ORs of colorectal adenoma associated with MTHFR 677C→T, 1298A→C, and combined genotype in the HPFS (1986–1995)

GenotypeAllMTHFR (1298)
1298AA1298AC1298CC
All  1.0 (ref) 1.09 (0.84–1.43)a 0.84 (0.50–1.41) 
  [186; 369]b [165; 299] [24; 57] 
MTHFR677     
677CC 1.0 (ref) 1.0 (ref) 0.98 (0.62–1.53) 0.75 (0.41–1.37) 
 [157; 299] [51; 92] [81; 150] [23; 56] 
677CT 0.99 (0.75–1.30) 0.87 (0.56–1.35) 1.04 (0.66–1.62)  
 [168; 325] [85; 179] [82; 145] [0; 1] 
677TT 0.93 (0.62–1.39) 0.90 (0.54–1.48)   
 [49; 101] [48; 98] [1; 3] [0; 0] 
GenotypeAllMTHFR (1298)
1298AA1298AC1298CC
All  1.0 (ref) 1.09 (0.84–1.43)a 0.84 (0.50–1.41) 
  [186; 369]b [165; 299] [24; 57] 
MTHFR677     
677CC 1.0 (ref) 1.0 (ref) 0.98 (0.62–1.53) 0.75 (0.41–1.37) 
 [157; 299] [51; 92] [81; 150] [23; 56] 
677CT 0.99 (0.75–1.30) 0.87 (0.56–1.35) 1.04 (0.66–1.62)  
 [168; 325] [85; 179] [82; 145] [0; 1] 
677TT 0.93 (0.62–1.39) 0.90 (0.54–1.48)   
 [49; 101] [48; 98] [1; 3] [0; 0] 
a

OR and 95% CI adjusted for matching variables (age, previous endoscopy, year of endoscopy), and smoking history, aspirin use, BMI, physical activity, and intakes of red meat, folate, and alcohol.

b

Numbers of cases and controls.

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