American Association for Cancer Research

Table 1

ORs of colorectal adenoma associated with MTHFR 677C→T, 1298A→C, and combined genotype in the HPFS (1986–1995)

Genotype	All	MTHFR (1298)
Genotype	All			1298AA	1298AC	1298CC
All		1.0 (ref)	1.09 (0.84–1.43)^a	0.84 (0.50–1.41)
		[186; 369]^b	[165; 299]	[24; 57]
MTHFR677
677CC	1.0 (ref)	1.0 (ref)	0.98 (0.62–1.53)	0.75 (0.41–1.37)
	[157; 299]	[51; 92]	[81; 150]	[23; 56]
677CT	0.99 (0.75–1.30)	0.87 (0.56–1.35)	1.04 (0.66–1.62)
	[168; 325]	[85; 179]	[82; 145]	[0; 1]
677TT	0.93 (0.62–1.39)	0.90 (0.54–1.48)
	[49; 101]	[48; 98]	[1; 3]	[0; 0]

Genotype	All	MTHFR (1298)
Genotype	All			1298AA	1298AC	1298CC
All		1.0 (ref)	1.09 (0.84–1.43)^a	0.84 (0.50–1.41)
		[186; 369]^b	[165; 299]	[24; 57]
MTHFR677
677CC	1.0 (ref)	1.0 (ref)	0.98 (0.62–1.53)	0.75 (0.41–1.37)
	[157; 299]	[51; 92]	[81; 150]	[23; 56]
677CT	0.99 (0.75–1.30)	0.87 (0.56–1.35)	1.04 (0.66–1.62)
	[168; 325]	[85; 179]	[82; 145]	[0; 1]
677TT	0.93 (0.62–1.39)	0.90 (0.54–1.48)
	[49; 101]	[48; 98]	[1; 3]	[0; 0]

OR and 95% CI adjusted for matching variables (age, previous endoscopy, year of endoscopy), and smoking history, aspirin use, BMI, physical activity, and intakes of red meat, folate, and alcohol.

Numbers of cases and controls.

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