Associations of breast cancer with combined IGF and steroid hormones among postmenopausal womena
| Variable . | IGF-I . | . | IGF-II . | . | IGFBP-3 . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | No.b . | OR (95% CI) . | No. . | OR (95% CI) . | No. . | OR (95% CI) . | |||
| Testosterone | |||||||||
| Low/lowc | 35/24 | 1.00 | 30/21 | 1.00 | 32/20 | 1.00 | |||
| High/low | 30/31 | 1.67 (0.78–3.61) | 35/35 | 1.35 (0.60–3.07) | 33/29 | 1.63 (0.71–3.72) | |||
| Low/high | 30/23 | 1.05 (0.46–2.41) | 35/26 | 1.18 (0.39–3.54) | 33/27 | 1.31 (0.55–3.12) | |||
| High/high | 35/48 | 2.15 (1.02–4.50) | 30/44 | 3.06 (1.10–8.53) | 32/50 | 2.68 (1.18–6.06) | |||
| Estrone | |||||||||
| Low/low | 33/22 | 1.00 | 25/18 | 1.00 | 39/22 | 1.00 | |||
| High/low | 31/32 | 1.84 (0.86–3.97) | 38/37 | 1.71 (0.67–4.36) | 26/27 | 2.13 (0.94–4.83) | |||
| Low/high | 31/27 | 1.22 (0.54–2.77) | 39/31 | 1.48 (0.47–4.70) | 25/27 | 1.70 (0.75–3.88) | |||
| High/high | 33/44 | 2.19 (1.06–4.56) | 26/39 | 2.77 (1.00–7.63) | 38/49 | 2.63 (1.21–5.73) | |||
| Estradiol | |||||||||
| Low/low | 35/22 | 1.00 | 22/20 | 1.00 | 41/27 | 1.00 | |||
| High/low | 30/33 | 1.88 (0.73–4.82) | 43/36 | 0.99 (0.39–2.58) | 24/22 | 1.62 (0.62–4.25) | |||
| Low/high | 29/35 | 1.93 (0.84–4.43) | 42/37 | 1.28 (0.43–3.82) | 23/30 | 1.77 (0.86–3.61) | |||
| High/high | 36/36 | 1.67 (0.70–3.98) | 23/33 | 2.24 (0.74–6.81) | 42/47 | 2.23 (0.84–5.93) | |||
| Estrone-S | |||||||||
| Low/low | 30/23 | 1.00 | 43/29 | 1.00 | 20/17 | 1.00 | |||
| High/low | 35/32 | 1.30 (0.60–2.82) | 22/27 | 2.02 (0.87–4.70) | 45/32 | 0.63 (0.25–1.58) | |||
| Low/high | 35/32 | 1.27 (0.60–2.69) | 22/26 | 2.62 (0.96–7.17) | 45/38 | 0.80 (0.34–1.88) | |||
| High/high | 30/39 | 1.72 (0.78–3.79) | 43/44 | 2.33 (0.86–6.29) | 20/39 | 1.78 (0.74–4.25) | |||
| DHEA-S | |||||||||
| Low/low | 39/28 | 1.00 | 35/25 | 1.00 | 34/21 | 1.00 | |||
| High/low | 26/27 | 1.50 (0.74–3.04) | 30/31 | 1.41 (0.67–2.96) | 31/28 | 1.63 (0.73–3.62) | |||
| Low/high | 26/24 | 1.37 (0.65–2.89) | 30/27 | 1.79 (0.64–4.97) | 31/31 | 1.81 (0.79–4.15) | |||
| High/high | 39/47 | 1.72 (0.84–3.50) | 35/43 | 2.47 (0.93–6.57) | 34/46 | 2.07 (0.99–4.35) | |||
| Variable . | IGF-I . | . | IGF-II . | . | IGFBP-3 . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | No.b . | OR (95% CI) . | No. . | OR (95% CI) . | No. . | OR (95% CI) . | |||
| Testosterone | |||||||||
| Low/lowc | 35/24 | 1.00 | 30/21 | 1.00 | 32/20 | 1.00 | |||
| High/low | 30/31 | 1.67 (0.78–3.61) | 35/35 | 1.35 (0.60–3.07) | 33/29 | 1.63 (0.71–3.72) | |||
| Low/high | 30/23 | 1.05 (0.46–2.41) | 35/26 | 1.18 (0.39–3.54) | 33/27 | 1.31 (0.55–3.12) | |||
| High/high | 35/48 | 2.15 (1.02–4.50) | 30/44 | 3.06 (1.10–8.53) | 32/50 | 2.68 (1.18–6.06) | |||
| Estrone | |||||||||
| Low/low | 33/22 | 1.00 | 25/18 | 1.00 | 39/22 | 1.00 | |||
| High/low | 31/32 | 1.84 (0.86–3.97) | 38/37 | 1.71 (0.67–4.36) | 26/27 | 2.13 (0.94–4.83) | |||
| Low/high | 31/27 | 1.22 (0.54–2.77) | 39/31 | 1.48 (0.47–4.70) | 25/27 | 1.70 (0.75–3.88) | |||
| High/high | 33/44 | 2.19 (1.06–4.56) | 26/39 | 2.77 (1.00–7.63) | 38/49 | 2.63 (1.21–5.73) | |||
| Estradiol | |||||||||
| Low/low | 35/22 | 1.00 | 22/20 | 1.00 | 41/27 | 1.00 | |||
| High/low | 30/33 | 1.88 (0.73–4.82) | 43/36 | 0.99 (0.39–2.58) | 24/22 | 1.62 (0.62–4.25) | |||
| Low/high | 29/35 | 1.93 (0.84–4.43) | 42/37 | 1.28 (0.43–3.82) | 23/30 | 1.77 (0.86–3.61) | |||
| High/high | 36/36 | 1.67 (0.70–3.98) | 23/33 | 2.24 (0.74–6.81) | 42/47 | 2.23 (0.84–5.93) | |||
| Estrone-S | |||||||||
| Low/low | 30/23 | 1.00 | 43/29 | 1.00 | 20/17 | 1.00 | |||
| High/low | 35/32 | 1.30 (0.60–2.82) | 22/27 | 2.02 (0.87–4.70) | 45/32 | 0.63 (0.25–1.58) | |||
| Low/high | 35/32 | 1.27 (0.60–2.69) | 22/26 | 2.62 (0.96–7.17) | 45/38 | 0.80 (0.34–1.88) | |||
| High/high | 30/39 | 1.72 (0.78–3.79) | 43/44 | 2.33 (0.86–6.29) | 20/39 | 1.78 (0.74–4.25) | |||
| DHEA-S | |||||||||
| Low/low | 39/28 | 1.00 | 35/25 | 1.00 | 34/21 | 1.00 | |||
| High/low | 26/27 | 1.50 (0.74–3.04) | 30/31 | 1.41 (0.67–2.96) | 31/28 | 1.63 (0.73–3.62) | |||
| Low/high | 26/24 | 1.37 (0.65–2.89) | 30/27 | 1.79 (0.64–4.97) | 31/31 | 1.81 (0.79–4.15) | |||
| High/high | 39/47 | 1.72 (0.84–3.50) | 35/43 | 2.47 (0.93–6.57) | 34/46 | 2.07 (0.99–4.35) | |||
Unadjusted conditional logistic regression analysis.
Number of control versus number of case.
Low/low, low steroids and low IGF-I or IGFBP-3; High/low, high steroids and low IGF-I or IGFBP-3; Low/high, low steroids and high IGF-I or IGFBP-3; High/high, high steroids and high IGF-I or IGFBP-3; Low, lower than median; High, higher than or equal to median.