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Table 3

Associations of breast cancer with IGFs and steroid hormonesa

Variable1st quartileb (Reference)2nd quartile OR (95% CI)3rd quartile OR (95% CI)4th quartile OR (95% CI)P for trendMedian cutoff
Premenopausal women       
 IGF-I 1.00 1.41 (0.72–2.77) 1.48 (0.72–3.06) 2.66 (1.40–5.05) 0.003 1.78c 
 IGF-II 1.00 1.88 (0.86–4.11) 1.15 (0.41–3.28) 1.69 (0.61–4.73) 0.378 0.82 
 IGFBP-3 1.00 1.17 (0.57–2.39) 2.17 (1.05–4.46) 4.26 (1.89–9.63) <0.001 2.56c 
 Estradiol 1.00 0.61 (0.31–1.18) 0.62 (0.33–1.15) 0.68 (0.37–1.26) 0.265 0.83 
 Estrone 1.00 1.02 (0.52–2.03) 1.44 (0.75–2.79) 1.46 (0.78–2.76) 0.149 1.44 
 Estrone-S 1.00 1.00 (0.53–1.91) 0.97 (0.47–1.99) 1.21 (0.65–2.27) 0.514 1.11 
 Testosterone 1.00 1.38 (0.62–3.06) 1.17 (0.51–2.66) 2.92 (1.27–6.70) 0.009 1.46 
 DHEA-S 1.00 0.80 (0.42–1.53) 0.92 (0.48–1.74) 1.43 (0.77–2.68) 0.187 0.85 
 SHBG 1.00 0.76 (0.39–1.48) 0.73 (0.37–1.43) 0.73 (0.36–1.49) 0.418 0.91 
 Progesterone 1.00 1.38 (0.70–2.72) 1.25 (0.62–2.55) 0.82 (0.40–1.70) 0.450  
Postmenopausal women       
 IGF-I 1.00 1.34 (0.61–2.96) 1.05 (0.44–2.52) 2.11 (0.92–4.86) 0.108 1.29 
 IGF-II 1.00 0.89 (0.46–1.72) 1.63 (0.68–3.90) 2.21 (0.70–6.96) 0.259 1.78 
 IGFBP-3 1.00 1.17 (0.58–2.39) 1.43 (0.71–2.89) 2.86 (1.02–7.99) 0.059 1.55 
 Estrone 1.00 0.81 (0.33–1.98) 0.82 (0.35–1.93) 2.67 (1.17–6.07) 0.007 1.79c 
 Estrone-S 1.00 0.56 (0.22–1.41) 1.41 (0.56–3.57) 0.72 (0.31–1.68) 1.000 1.32 
 Testosterone 1.00 0.58 (0.25–1.35) 1.04 (0.47–2.33) 1.87 (0.84–4.20) 0.034 1.89c 
 DHEA-S 1.00 1.89 (0.87–4.11) 1.27 (0.61–2.65) 2.92 (1.28–6.67) 0.037 1.40 
 SHBG 1.00 1.00 (0.46–2.19) 0.86 (0.39–1.88) 0.79 (0.36–1.74) 0.487 0.92 
Variable1st quartileb (Reference)2nd quartile OR (95% CI)3rd quartile OR (95% CI)4th quartile OR (95% CI)P for trendMedian cutoff
Premenopausal women       
 IGF-I 1.00 1.41 (0.72–2.77) 1.48 (0.72–3.06) 2.66 (1.40–5.05) 0.003 1.78c 
 IGF-II 1.00 1.88 (0.86–4.11) 1.15 (0.41–3.28) 1.69 (0.61–4.73) 0.378 0.82 
 IGFBP-3 1.00 1.17 (0.57–2.39) 2.17 (1.05–4.46) 4.26 (1.89–9.63) <0.001 2.56c 
 Estradiol 1.00 0.61 (0.31–1.18) 0.62 (0.33–1.15) 0.68 (0.37–1.26) 0.265 0.83 
 Estrone 1.00 1.02 (0.52–2.03) 1.44 (0.75–2.79) 1.46 (0.78–2.76) 0.149 1.44 
 Estrone-S 1.00 1.00 (0.53–1.91) 0.97 (0.47–1.99) 1.21 (0.65–2.27) 0.514 1.11 
 Testosterone 1.00 1.38 (0.62–3.06) 1.17 (0.51–2.66) 2.92 (1.27–6.70) 0.009 1.46 
 DHEA-S 1.00 0.80 (0.42–1.53) 0.92 (0.48–1.74) 1.43 (0.77–2.68) 0.187 0.85 
 SHBG 1.00 0.76 (0.39–1.48) 0.73 (0.37–1.43) 0.73 (0.36–1.49) 0.418 0.91 
 Progesterone 1.00 1.38 (0.70–2.72) 1.25 (0.62–2.55) 0.82 (0.40–1.70) 0.450  
Postmenopausal women       
 IGF-I 1.00 1.34 (0.61–2.96) 1.05 (0.44–2.52) 2.11 (0.92–4.86) 0.108 1.29 
 IGF-II 1.00 0.89 (0.46–1.72) 1.63 (0.68–3.90) 2.21 (0.70–6.96) 0.259 1.78 
 IGFBP-3 1.00 1.17 (0.58–2.39) 1.43 (0.71–2.89) 2.86 (1.02–7.99) 0.059 1.55 
 Estrone 1.00 0.81 (0.33–1.98) 0.82 (0.35–1.93) 2.67 (1.17–6.07) 0.007 1.79c 
 Estrone-S 1.00 0.56 (0.22–1.41) 1.41 (0.56–3.57) 0.72 (0.31–1.68) 1.000 1.32 
 Testosterone 1.00 0.58 (0.25–1.35) 1.04 (0.47–2.33) 1.87 (0.84–4.20) 0.034 1.89c 
 DHEA-S 1.00 1.89 (0.87–4.11) 1.27 (0.61–2.65) 2.92 (1.28–6.67) 0.037 1.40 
 SHBG 1.00 1.00 (0.46–2.19) 0.86 (0.39–1.88) 0.79 (0.36–1.74) 0.487 0.92 
a

Unadjusted conditional logistic regression analysis.

b

Lowest quartile.

c

P < 0.05.

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