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Table 5

Kaplan-Meier DFS (n = 138) and OS (n = 160) analysis of biological variables in patients with CRC

No. patientsDFS (%) 5 yrsPNo. patientsOS (%) 5 yrsP
DNA-ploidy statusa       
 Diploid 38 75  40 77  
 An. Monoclonal 81 34  98 33  
 An. Multiclonal 19 10 <0.01 22 <0.01 
SPFb       
 ≤18.3% 72 60  81 59  
 >18.3% 66 22 <0.01 79 21 <0.01 
p53c       
 No mutations 88 51  100 49  
 Any mutations 48 25 <0.01 58 26 <0.01 
 No mutations 88 51  100 49  
 Mutation in nonconserved areas 19 32  20 40  
 Mutation in conserved areas 29 21 <0.05 38 18 <0.05 
 No mutations 88 51  100 49  
 Mutation outside L3/LSH 26 27  29 34  
 Mutations in LSH 33  11 27  
 Mutations in L3 13 15 <0.05 18 11 <0.01 
 No mutations 88 51  100 49  
 Missense mutations 33 24  39 28  
 Frameshift mutations 14 29 <0.05 18 22 <0.05 
No. patientsDFS (%) 5 yrsPNo. patientsOS (%) 5 yrsP
DNA-ploidy statusa       
 Diploid 38 75  40 77  
 An. Monoclonal 81 34  98 33  
 An. Multiclonal 19 10 <0.01 22 <0.01 
SPFb       
 ≤18.3% 72 60  81 59  
 >18.3% 66 22 <0.01 79 21 <0.01 
p53c       
 No mutations 88 51  100 49  
 Any mutations 48 25 <0.01 58 26 <0.01 
 No mutations 88 51  100 49  
 Mutation in nonconserved areas 19 32  20 40  
 Mutation in conserved areas 29 21 <0.05 38 18 <0.05 
 No mutations 88 51  100 49  
 Mutation outside L3/LSH 26 27  29 34  
 Mutations in LSH 33  11 27  
 Mutations in L3 13 15 <0.05 18 11 <0.01 
 No mutations 88 51  100 49  
 Missense mutations 33 24  39 28  
 Frameshift mutations 14 29 <0.05 18 22 <0.05 
a

All DNA-aneuploid subgroups are compared with patients with DNA-diploid tumors.

b

All high SPF subgroups are compared with patients with low SPF tumors.

c

All mutation subgroups are compared with patients with no mutations (wild-type p53).

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