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Table 4

Lifetime gonadal hormone exposure and bone sarcoma risk in a cohort of 683 Rottweiler dogs

Dogs with bone sarcoma (no.)Dogs without bone sarcoma (no.)Total dog-monthsBone sarcoma incidence rate (95% CI)aRR (95% CI)P
Total population 86 597 71,004 12.1 (9.6–14.7)   
Gender       
 Male 35 259 30,228 11.6 (7.8–15.4) 1.0  
 Female 51 338 40,776 12.5 (9.1–15.9) 1.1 (0.7–1.7) 0.74 
Male gonadal exposure subgroup       
 Castrated before 1 yr of age 25 3,168 28.4 (9.8–47.0) 3.8 (1.5–9.2) 0.002 
 Castrated 1–3.5 yr of age 57 6,228 12.8 (3.9–21.8) 1.7 (0.7–4.3) 0.31 
 Castrated after 3.5 yr of age 57 7,632 10.5 (3.3–17.8) 1.4 (0.6–3.5) 0.48 
 Sexually intact 10 120 13,212 7.6 (2.9–12.3) 1.0  
    P trend = 0.008   
Female gonadal exposure subgroup       
 Spayed before 1 yr of age 18 57 7,176 25.1 (13.5–36.7) 3.1 (1.1–8.3) 0.02 
 Spayed 1–5 yr of age 14 108 12,612 11.1 (5.3–16.9) 1.4 (0.5–3.8) 0.63 
 Spayed after 5 yr of age 14 108 14,856 9.4 (4.5–14.3) 1.2 (0.4–3.2) 1.00 
 Sexually intact 64 6,144 8.1 (1.0–15.3) 1.0  
    P trend = 0.006   
Dogs with bone sarcoma (no.)Dogs without bone sarcoma (no.)Total dog-monthsBone sarcoma incidence rate (95% CI)aRR (95% CI)P
Total population 86 597 71,004 12.1 (9.6–14.7)   
Gender       
 Male 35 259 30,228 11.6 (7.8–15.4) 1.0  
 Female 51 338 40,776 12.5 (9.1–15.9) 1.1 (0.7–1.7) 0.74 
Male gonadal exposure subgroup       
 Castrated before 1 yr of age 25 3,168 28.4 (9.8–47.0) 3.8 (1.5–9.2) 0.002 
 Castrated 1–3.5 yr of age 57 6,228 12.8 (3.9–21.8) 1.7 (0.7–4.3) 0.31 
 Castrated after 3.5 yr of age 57 7,632 10.5 (3.3–17.8) 1.4 (0.6–3.5) 0.48 
 Sexually intact 10 120 13,212 7.6 (2.9–12.3) 1.0  
    P trend = 0.008   
Female gonadal exposure subgroup       
 Spayed before 1 yr of age 18 57 7,176 25.1 (13.5–36.7) 3.1 (1.1–8.3) 0.02 
 Spayed 1–5 yr of age 14 108 12,612 11.1 (5.3–16.9) 1.4 (0.5–3.8) 0.63 
 Spayed after 5 yr of age 14 108 14,856 9.4 (4.5–14.3) 1.2 (0.4–3.2) 1.00 
 Sexually intact 64 6,144 8.1 (1.0–15.3) 1.0  
    P trend = 0.006   
a

Incidence rate expressed as number of bone sarcomas per 10,000 dog-months.

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