Lifetime gonadal hormone exposure and bone sarcoma risk in a cohort of 683 Rottweiler dogs
| . | Dogs with bone sarcoma (no.) . | Dogs without bone sarcoma (no.) . | Total dog-months . | Bone sarcoma incidence rate (95% CI)a . | RR (95% CI) . | P . |
|---|---|---|---|---|---|---|
| Total population | 86 | 597 | 71,004 | 12.1 (9.6–14.7) | ||
| Gender | ||||||
| Male | 35 | 259 | 30,228 | 11.6 (7.8–15.4) | 1.0 | |
| Female | 51 | 338 | 40,776 | 12.5 (9.1–15.9) | 1.1 (0.7–1.7) | 0.74 |
| Male gonadal exposure subgroup | ||||||
| Castrated before 1 yr of age | 9 | 25 | 3,168 | 28.4 (9.8–47.0) | 3.8 (1.5–9.2) | 0.002 |
| Castrated 1–3.5 yr of age | 8 | 57 | 6,228 | 12.8 (3.9–21.8) | 1.7 (0.7–4.3) | 0.31 |
| Castrated after 3.5 yr of age | 8 | 57 | 7,632 | 10.5 (3.3–17.8) | 1.4 (0.6–3.5) | 0.48 |
| Sexually intact | 10 | 120 | 13,212 | 7.6 (2.9–12.3) | 1.0 | |
| P trend = 0.008 | ||||||
| Female gonadal exposure subgroup | ||||||
| Spayed before 1 yr of age | 18 | 57 | 7,176 | 25.1 (13.5–36.7) | 3.1 (1.1–8.3) | 0.02 |
| Spayed 1–5 yr of age | 14 | 108 | 12,612 | 11.1 (5.3–16.9) | 1.4 (0.5–3.8) | 0.63 |
| Spayed after 5 yr of age | 14 | 108 | 14,856 | 9.4 (4.5–14.3) | 1.2 (0.4–3.2) | 1.00 |
| Sexually intact | 5 | 64 | 6,144 | 8.1 (1.0–15.3) | 1.0 | |
| P trend = 0.006 |
| . | Dogs with bone sarcoma (no.) . | Dogs without bone sarcoma (no.) . | Total dog-months . | Bone sarcoma incidence rate (95% CI)a . | RR (95% CI) . | P . |
|---|---|---|---|---|---|---|
| Total population | 86 | 597 | 71,004 | 12.1 (9.6–14.7) | ||
| Gender | ||||||
| Male | 35 | 259 | 30,228 | 11.6 (7.8–15.4) | 1.0 | |
| Female | 51 | 338 | 40,776 | 12.5 (9.1–15.9) | 1.1 (0.7–1.7) | 0.74 |
| Male gonadal exposure subgroup | ||||||
| Castrated before 1 yr of age | 9 | 25 | 3,168 | 28.4 (9.8–47.0) | 3.8 (1.5–9.2) | 0.002 |
| Castrated 1–3.5 yr of age | 8 | 57 | 6,228 | 12.8 (3.9–21.8) | 1.7 (0.7–4.3) | 0.31 |
| Castrated after 3.5 yr of age | 8 | 57 | 7,632 | 10.5 (3.3–17.8) | 1.4 (0.6–3.5) | 0.48 |
| Sexually intact | 10 | 120 | 13,212 | 7.6 (2.9–12.3) | 1.0 | |
| P trend = 0.008 | ||||||
| Female gonadal exposure subgroup | ||||||
| Spayed before 1 yr of age | 18 | 57 | 7,176 | 25.1 (13.5–36.7) | 3.1 (1.1–8.3) | 0.02 |
| Spayed 1–5 yr of age | 14 | 108 | 12,612 | 11.1 (5.3–16.9) | 1.4 (0.5–3.8) | 0.63 |
| Spayed after 5 yr of age | 14 | 108 | 14,856 | 9.4 (4.5–14.3) | 1.2 (0.4–3.2) | 1.00 |
| Sexually intact | 5 | 64 | 6,144 | 8.1 (1.0–15.3) | 1.0 | |
| P trend = 0.006 |
Incidence rate expressed as number of bone sarcomas per 10,000 dog-months.