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Table 1

P gene variants and eye color

Arg305TrpArg419GlnCombined variants
Arg/ArgArg/Trp or Trp/TrpArg/ArgArg/Gln or Gln/GlnArg onlyAny Trp or Gln
Blue/gray 221 (90.2%) 24 (9.8%) 221 (89.1%) 27 (10.9%) 185 (78.7%) 50 (21.3%) 
Green/hazel 142 (88.2%) 19 (11.8%) 121 (72.9%) 45 (27.1%) 101 (63.5%) 58 (36.5%) 
Brown/black 154 (78.6%) 42 (21.4%) 166 (83.8%) 32 (16.2%) 122 (64.2%) 68 (35.8%) 
χ2 (df = 2) 13.13 (P < 0.001)  18.69 (P < 0.001)  14.68 (P < 0.001)  
       
ORa 1.12 (0.59–2.15)  3.00 (1.76–5.11)  2.02 (1.28–3.18)  
ORb 2.48 (1.43–4.30)  1.65 (0.85–2.88)  2.08 (1.34–3.23)  
ORc 1.78 (1.07–2.96)  2.45 (1.39–3.62)  2.05 (1.39–3.01)  
Arg305TrpArg419GlnCombined variants
Arg/ArgArg/Trp or Trp/TrpArg/ArgArg/Gln or Gln/GlnArg onlyAny Trp or Gln
Blue/gray 221 (90.2%) 24 (9.8%) 221 (89.1%) 27 (10.9%) 185 (78.7%) 50 (21.3%) 
Green/hazel 142 (88.2%) 19 (11.8%) 121 (72.9%) 45 (27.1%) 101 (63.5%) 58 (36.5%) 
Brown/black 154 (78.6%) 42 (21.4%) 166 (83.8%) 32 (16.2%) 122 (64.2%) 68 (35.8%) 
χ2 (df = 2) 13.13 (P < 0.001)  18.69 (P < 0.001)  14.68 (P < 0.001)  
       
ORa 1.12 (0.59–2.15)  3.00 (1.76–5.11)  2.02 (1.28–3.18)  
ORb 2.48 (1.43–4.30)  1.65 (0.85–2.88)  2.08 (1.34–3.23)  
ORc 1.78 (1.07–2.96)  2.45 (1.39–3.62)  2.05 (1.39–3.01)  
a

OR comparison of blue/gray versus green/hazel adjusted for presence/absence of MM and presence/absence of DN.

b

OR comparison of blue/gray versus brown/black adjusted for presence/absence of MM and presence/absence of DN.

c

OR comparison of blue/gray versus green/hazel/brown/black adjusted for presence/absence of MM and presence/absence of DN.

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