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Table 3

Age-adjusted relative risk of CRC mortality associated with potential risk factors in the CHA Detection Project in Industry

Risk factorMenWomen
No. of deathsTotal person-yearsAge-adjusted RR95% CINo. of deathsTotal person-yearsAge-adjusted RR95% CI
PLG, mg/dl         
 ≤19 56 221,085 1.00  31 185,374 1.00  
 120–159 71 163,649 1.10 0.77–1.57 56 118,352 1.74 1.11–2.72 
 160–199 33 72,952 0.86 0.55–1.33 23 50,212 1.32 0.76–2.30 
 ≥200 31 33,307 1.51 0.96–2.40 16 21,994 1.86 1.00–3.45 
P for trend   0.22    0.10  
Quartiles of BMI,a kg/m2         
 Q1 33 125,420 1.00  19 95,163 1.00  
 Q2 41 124,038 1.07 0.68–1.69 26 95,562 0.92 0.51–1.67 
 Q3 56 123,046 1.27 0.82–1.96 41 93,868 1.11 0.64–1.93 
 Q4 61 118,489 1.40 0.91–2.14 40 91,339 0.94 0.54–1.65 
P for trend   0.08    0.86  
Quartiles of SBP,b mm Hg         
 Q1 35 126,959 1.00  14 83,448 1.00  
 Q2 37 120,775 1.00 0.63–1.58 20 88,873 1.06 0.53–2.09 
 Q3 39 115,470 0.98 0.62–1.55 46 128,682 1.18 0.64–2.17 
 Q4 80 127,572 1.36 0.91–2.05 46 74,610 1.24 0.66–2.31 
P for trend   0.07    0.47  
Quartiles of heart rate,c beats/min         
 Q1 41 104,529 1.00  30 78,870 1.00  
 Q2 44 105,384 1.04 0.68–1.60 33 90,811 1.07 0.65–1.75 
 Q3 33 105,228 0.84 0.53–1.32 32 82,944 1.33 0.80–2.19 
 Q4 51 102,488 1.32 0.88–2.00 22 85,100 1.03 0.59–1.79 
P for trend   0.23    0.74  
Quartiles of uric acid,d mg/dl         
 Q1 35 86,588 1.00  16 79,560 1.00  
 Q2 30 73,028 1.04 0.64–1.70 23 70,569 1.26 0.66–2.39 
 Q3 30 87,553 0.87 0.53–1.41 25 66,817 1.20 0.64–2.26 
 Q4 31 76,325 1.00 0.62–1.62 39 73,285 1.31 0.72–2.38 
P for trend   0.86    0.44  
Quartiles for height,e        
 Q1 55 126,914 1.00  42 87,287 1.00  
 Q2 45 132,858 0.92 0.62–1.37 36 109,310 0.84 0.54–1.32 
 Q3 51 126,886 1.34 0.91–1.97 30 104,098 0.86 0.54–1.38 
 Q4 40 104,335 1.50 0.99–2.28 18 75,238 0.92 0.52–1.61 
P for trend   0.03    0.72  
Education         
 Less than high school 46 88,223 1.00  33 76,233 1.00  
 High school graduate 75 150,900 1.37 0.94–1.99 69 189,244 1.50 0.98–2.29 
 Some college or trade 25 95,276 0.80 0.49–1.30 20 65,379 1.47 0.84–2.59 
 College graduate 45 156,594 0.93 0.61–1.41 45,077 0.44 0.16–1.26 
P for trend   0.31    0.75  
Smoking         
 Never smoked 53 134,577 1.00  62 169,372 1.00  
 Past smoker 68 147,099 0.97 0.68–1.39 15 60,105 0.83 0.47–1.46 
 Smoke 1–20 cigsf/day 40 139,531 0.91 0.60–1.38 41 119,964 1.39 0.93–2.08 
 Smoke >20 cigs/day 30 69,787 1.36 0.86–2.13 26,491 1.40 0.66–2.94 
Race         
 White/other 182 459,302 1.00  117 324,321 1.00  
 African-American 31,691 0.95 0.49–1.86 51,611 1.33 0.66–2.70 
Insulin resistance clustering: in the upper quartile of the distribution on PLG, SBP, BMI, or heart rate         
 0 of 4 components 43 167,780 1.00  29 136,083 1.00  
 1 of 4 components 47 136,321 1.00 0.66–1.52 40 116,437 1.11 0.68–1.80 
 2 of 4 components 48 75,151 1.50 0.99–2.29 30 57,738 1.21 0.72–2.04 
 ≥3 of 4 components 31 38,213 1.67 1.04–2.68 18 27,310 1.25 0.68–2.29 
Risk factorMenWomen
No. of deathsTotal person-yearsAge-adjusted RR95% CINo. of deathsTotal person-yearsAge-adjusted RR95% CI
PLG, mg/dl         
 ≤19 56 221,085 1.00  31 185,374 1.00  
 120–159 71 163,649 1.10 0.77–1.57 56 118,352 1.74 1.11–2.72 
 160–199 33 72,952 0.86 0.55–1.33 23 50,212 1.32 0.76–2.30 
 ≥200 31 33,307 1.51 0.96–2.40 16 21,994 1.86 1.00–3.45 
P for trend   0.22    0.10  
Quartiles of BMI,a kg/m2         
 Q1 33 125,420 1.00  19 95,163 1.00  
 Q2 41 124,038 1.07 0.68–1.69 26 95,562 0.92 0.51–1.67 
 Q3 56 123,046 1.27 0.82–1.96 41 93,868 1.11 0.64–1.93 
 Q4 61 118,489 1.40 0.91–2.14 40 91,339 0.94 0.54–1.65 
P for trend   0.08    0.86  
Quartiles of SBP,b mm Hg         
 Q1 35 126,959 1.00  14 83,448 1.00  
 Q2 37 120,775 1.00 0.63–1.58 20 88,873 1.06 0.53–2.09 
 Q3 39 115,470 0.98 0.62–1.55 46 128,682 1.18 0.64–2.17 
 Q4 80 127,572 1.36 0.91–2.05 46 74,610 1.24 0.66–2.31 
P for trend   0.07    0.47  
Quartiles of heart rate,c beats/min         
 Q1 41 104,529 1.00  30 78,870 1.00  
 Q2 44 105,384 1.04 0.68–1.60 33 90,811 1.07 0.65–1.75 
 Q3 33 105,228 0.84 0.53–1.32 32 82,944 1.33 0.80–2.19 
 Q4 51 102,488 1.32 0.88–2.00 22 85,100 1.03 0.59–1.79 
P for trend   0.23    0.74  
Quartiles of uric acid,d mg/dl         
 Q1 35 86,588 1.00  16 79,560 1.00  
 Q2 30 73,028 1.04 0.64–1.70 23 70,569 1.26 0.66–2.39 
 Q3 30 87,553 0.87 0.53–1.41 25 66,817 1.20 0.64–2.26 
 Q4 31 76,325 1.00 0.62–1.62 39 73,285 1.31 0.72–2.38 
P for trend   0.86    0.44  
Quartiles for height,e        
 Q1 55 126,914 1.00  42 87,287 1.00  
 Q2 45 132,858 0.92 0.62–1.37 36 109,310 0.84 0.54–1.32 
 Q3 51 126,886 1.34 0.91–1.97 30 104,098 0.86 0.54–1.38 
 Q4 40 104,335 1.50 0.99–2.28 18 75,238 0.92 0.52–1.61 
P for trend   0.03    0.72  
Education         
 Less than high school 46 88,223 1.00  33 76,233 1.00  
 High school graduate 75 150,900 1.37 0.94–1.99 69 189,244 1.50 0.98–2.29 
 Some college or trade 25 95,276 0.80 0.49–1.30 20 65,379 1.47 0.84–2.59 
 College graduate 45 156,594 0.93 0.61–1.41 45,077 0.44 0.16–1.26 
P for trend   0.31    0.75  
Smoking         
 Never smoked 53 134,577 1.00  62 169,372 1.00  
 Past smoker 68 147,099 0.97 0.68–1.39 15 60,105 0.83 0.47–1.46 
 Smoke 1–20 cigsf/day 40 139,531 0.91 0.60–1.38 41 119,964 1.39 0.93–2.08 
 Smoke >20 cigs/day 30 69,787 1.36 0.86–2.13 26,491 1.40 0.66–2.94 
Race         
 White/other 182 459,302 1.00  117 324,321 1.00  
 African-American 31,691 0.95 0.49–1.86 51,611 1.33 0.66–2.70 
Insulin resistance clustering: in the upper quartile of the distribution on PLG, SBP, BMI, or heart rate         
 0 of 4 components 43 167,780 1.00  29 136,083 1.00  
 1 of 4 components 47 136,321 1.00 0.66–1.52 40 116,437 1.11 0.68–1.80 
 2 of 4 components 48 75,151 1.50 0.99–2.29 30 57,738 1.21 0.72–2.04 
 ≥3 of 4 components 31 38,213 1.67 1.04–2.68 18 27,310 1.25 0.68–2.29 
a

Cutpoints for quartiles of BMI (kg/m2) for men were ≤24.13, 24.14–26.29, 26.30–28.63, and ≥28.65; for women, ≤20.97, 20.98–23.23, 23.24–26.17, and ≥26.22.

b

Cutpoints for SBP (mm HG) for men were ≤128, 130–138, 140–148, and ≥150; for women, ≤118, 120–129, 130–140, and ≥142.

c

Cutpoints for heart rate (beats/min) for men were ≤67, 68–74, 75–83, and ≥84; for women, ≤69, 70–76, 77–85, ≥86.

d

Cutpoints for uric acid (mg/dl) for men were ≤5.3, 5.4–6.0, 6.1–6.9, ≥7.0; for women, ≤3.7, 3.8–4.3, 4.4–5.0, ≥5.1.

e

Cutpoints for height (cm) for men were ≤170.2, 172.7–175.3, 177.7–180.3, and ≥182.9; for women, ≤157.5, 160.0–162.6, 165.1–167.6, and ≥170.2.

f

cigs, cigarettes.

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