American Association for Cancer Research

Table 4

Association between COMT genotype and the risk for breast cancer according to BMI stratified by menopausal status

	Premenopausal			Postmenopausal
		Case/control	OR^a (95% CI)	Case/control	OR^a (95% CI)
BMI ≤25.4 kg/m²
HH	28/28	1.0	25/23	1.0
HL	48/70	0.69 (0.35–1.35)	59/51	0.77 (0.35–1.70)
LL	24/27	0.93 (0.41–2.09)	23/40	0.33 (0.13–0.83)^b
HL or LL	72/97	0.75 (0.40–1.43)	82/91	0.57 (0.27–1.21)
BMI >25.4 kg/m²
HH	16/13	1.0	42/36	1.0
HL	31/40	0.48 (0.18–1.26)	91/73	1.22 (0.66–2.26)
LL	17/22	0.38 (0.12–1.17)^c	62/54	1.26 (0.66–2.42)
HL or LL	48/62	0.44 (0.17–1.12)	153/127	1.24 (0.70–2.20)

	Premenopausal			Postmenopausal
		Case/control	OR^a (95% CI)	Case/control	OR^a (95% CI)
BMI ≤25.4 kg/m²
HH	28/28	1.0	25/23	1.0
HL	48/70	0.69 (0.35–1.35)	59/51	0.77 (0.35–1.70)
LL	24/27	0.93 (0.41–2.09)	23/40	0.33 (0.13–0.83)^b
HL or LL	72/97	0.75 (0.40–1.43)	82/91	0.57 (0.27–1.21)
BMI >25.4 kg/m²
HH	16/13	1.0	42/36	1.0
HL	31/40	0.48 (0.18–1.26)	91/73	1.22 (0.66–2.26)
LL	17/22	0.38 (0.12–1.17)^c	62/54	1.26 (0.66–2.42)
HL or LL	48/62	0.44 (0.17–1.12)	153/127	1.24 (0.70–2.20)

ORs and 95% CIs adjusted for age, age at menarche, age at first full term pregnancy, number of full term pregnancies, first degree family history of breast cancer, history of benign breast disease, and postmenopausal use of estrogen.

P for trend = 0.01.

P for trend = 0.09.

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