American Association for Cancer Research

Table 3

Association of genetic polymorphisms and tobacco smoking with the risk of ovarian cancer

Genotype	Never smoked							Ever smoked		P^b for interaction
Genotype		Cases	Controls	OR^a	95% CI	Cases	Controls	OR^a	95% CI	P^b for interaction
CYP1A1 (MspI)
m1/m1	35	47	1^c		19	29	0.8	0.4–1.9
Any m2	36	50	0.9	0.5–1.8	32	18	2.6	1.2–6.0	0.03
CYP1A1 (Ile/Val)
A/A	50	64	1^c		40	38	1.4	0.7–2.7
Any G	22	33	0.7	0.4–1.5	12	9	1.8	0.6–5.1	0.37
CYP1A2
A/A	45	52	1^c		28	15	2.6	1.1–5.9
Any C	24	42	0.7	0.4–1.3	19	29	0.9	0.4–1.9	0.15
CYP1B1
Leu/Leu	39	63	1^c		28	32	1.3	0.6–9.3
Any Val	37	34	1.9	0.9–3.7	24	15	3.8	1.6–9.8	0.54
COMT
Val/Val	34	45	1^c		18	23	1.2	0.5–2.9
Any Met	39	52	1.2	0.6–2.2	34	24	2.2	1.0–4.7	0.36

Genotype	Never smoked							Ever smoked		P^b for interaction
Genotype		Cases	Controls	OR^a	95% CI	Cases	Controls	OR^a	95% CI	P^b for interaction
CYP1A1 (MspI)
m1/m1	35	47	1^c		19	29	0.8	0.4–1.9
Any m2	36	50	0.9	0.5–1.8	32	18	2.6	1.2–6.0	0.03
CYP1A1 (Ile/Val)
A/A	50	64	1^c		40	38	1.4	0.7–2.7
Any G	22	33	0.7	0.4–1.5	12	9	1.8	0.6–5.1	0.37
CYP1A2
A/A	45	52	1^c		28	15	2.6	1.1–5.9
Any C	24	42	0.7	0.4–1.3	19	29	0.9	0.4–1.9	0.15
CYP1B1
Leu/Leu	39	63	1^c		28	32	1.3	0.6–9.3
Any Val	37	34	1.9	0.9–3.7	24	15	3.8	1.6–9.8	0.54
COMT
Val/Val	34	45	1^c		18	23	1.2	0.5–2.9
Any Met	39	52	1.2	0.6–2.2	34	24	2.2	1.0–4.7	0.36

Adjusted by multiple unconditional logistic regression for age, ethnicity, education, pregnancy history, oral contraceptive pill use, history of tubal ligation, and regularity of menstrual cycles.

Based on the likelihood ratio test comparing models with and without an interaction term.

Reference category.

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