American Association for Cancer Research

Table 1

Frequency (%) of the NQO1 gene homozygous variant among lung cancer patients and controls defined by demographic characteristics

	Case (%)							Control (%)
		n	TT^a	CT^b	CC^c	n	TT^a	CT^b	CC^c
Total	814	2.8	31.9	65.2	1123	3.7	31.0	65.3
Gender
Male	445	2.9	30.1	67.0	506	4.4	27.5	68.2
Female	369	2.7	34.2	63.1	617	3.2	33.9	62.9
Race
Caucasian	780	2.7	31.5	65.8	1096	3.7	31.1	65.2
Other	34	5.9	41.2	52.9	27	3.7	22.2	74.1
Age (yr)
<55	139	2.2	32.4	65.5	423	4.0	28.1	67.9
55–64	191	3.1	34.0	62.8	256	1.6	32.0	66.4
>64	484	2.9	31.0	66.1	444	4.7	33.1	62.2
Smoking Status
Never	50	0.0	36.0	64.0	396	4.6	33.6	61.9
Former	432	3.0	31.0	66.0	515	2.7	28.7	68.5
Current	332	3.0	32.2	64.8	211	4.7	31.8	63.5
Cigarettes/day
1–5	25	4.0	4.0	92.0	79	1.3	25.3	73.4
>5–20	367	3.0	31.1	65.9	395	3.5	32.2	64.3
>20–40	381	3.4	36.5	60.1	200	3.0	28.0	69.0
>40	119	2.5	28.6	68.9	47	4.3	21.3	74.4
Years since cessation (ex-smokers)
1–4	102	2.9	31.4	65.7	55	1.8	32.7	65.5
>4–14	158	2.5	29.8	67.7	153	2.0	24.2	73.8
>14–29	128	2.3	31.3	66.4	195	4.1	30.8	65.1
>29	44	6.8	34.1	59.1	112	1.8	29.5	68.7
Yr smoked
≤10	16	12.5	37.5	50.0	104	1.9	24.0	74.1
>10–20	42	2.4	31.0	66.6	139	2.9	25.2	71.9
>20–30	115	1.7	29.6	68.7	192	2.1	29.2	68.8
>30–40	228	1.8	31.6	66.6	158	3.8	33.5	62.7
>40–50	204	3.4	28.4	68.1	94	5.3	34.0	60.7
>50–60	126	3.2	36.5	60.3	30	6.7	30.0	63.3
>60	19	5.3	42.1	52.6	4	0.0	75.0	25.0
Family history of cancer
No	251	2.8	33.9	63.3	436	4.4	30.5	65.1
Yes	508	2.6	31.1	66.3	631	3.5	31.2	65.3

	Case (%)							Control (%)
		n	TT^a	CT^b	CC^c	n	TT^a	CT^b	CC^c
Total	814	2.8	31.9	65.2	1123	3.7	31.0	65.3
Gender
Male	445	2.9	30.1	67.0	506	4.4	27.5	68.2
Female	369	2.7	34.2	63.1	617	3.2	33.9	62.9
Race
Caucasian	780	2.7	31.5	65.8	1096	3.7	31.1	65.2
Other	34	5.9	41.2	52.9	27	3.7	22.2	74.1
Age (yr)
<55	139	2.2	32.4	65.5	423	4.0	28.1	67.9
55–64	191	3.1	34.0	62.8	256	1.6	32.0	66.4
>64	484	2.9	31.0	66.1	444	4.7	33.1	62.2
Smoking Status
Never	50	0.0	36.0	64.0	396	4.6	33.6	61.9
Former	432	3.0	31.0	66.0	515	2.7	28.7	68.5
Current	332	3.0	32.2	64.8	211	4.7	31.8	63.5
Cigarettes/day
1–5	25	4.0	4.0	92.0	79	1.3	25.3	73.4
>5–20	367	3.0	31.1	65.9	395	3.5	32.2	64.3
>20–40	381	3.4	36.5	60.1	200	3.0	28.0	69.0
>40	119	2.5	28.6	68.9	47	4.3	21.3	74.4
Years since cessation (ex-smokers)
1–4	102	2.9	31.4	65.7	55	1.8	32.7	65.5
>4–14	158	2.5	29.8	67.7	153	2.0	24.2	73.8
>14–29	128	2.3	31.3	66.4	195	4.1	30.8	65.1
>29	44	6.8	34.1	59.1	112	1.8	29.5	68.7
Yr smoked
≤10	16	12.5	37.5	50.0	104	1.9	24.0	74.1
>10–20	42	2.4	31.0	66.6	139	2.9	25.2	71.9
>20–30	115	1.7	29.6	68.7	192	2.1	29.2	68.8
>30–40	228	1.8	31.6	66.6	158	3.8	33.5	62.7
>40–50	204	3.4	28.4	68.1	94	5.3	34.0	60.7
>50–60	126	3.2	36.5	60.3	30	6.7	30.0	63.3
>60	19	5.3	42.1	52.6	4	0.0	75.0	25.0
Family history of cancer
No	251	2.8	33.9	63.3	436	4.4	30.5	65.1
Yes	508	2.6	31.1	66.3	631	3.5	31.2	65.3

Homozygous variant.

Heterozygous.

Homozygous wild-type.