American Association for Cancer Research

Table 2

Results of sibling-pair linkage analysis of breast cancer in 13 Iowa families: proportion of alleles shared IBD and statistical significance

Locus	Proportion of alleles IBD					P
Locus		Concordant unaffected	Discordant	Concordant affected	Model 1^a	Model 2^b	Model 3^c	Model 4^d
D2S119	0.43	0.46	0.50	0.558	0.382	0.594	0.546
D2S123	0.38	0.47	0.41	0.841	0.719	0.890	0.862
D3S1277	0.49	0.51	0.64	0.419	0.276	0.422	0.426
D3S1611	0.55	0.54	0.45	0.651	0.267	0.795	0.587
INT2	0.48	0.51	0.40	0.723	0.350	0.802	0.705
ESR	0.46	0.55	0.61	0.711	0.450	0.502	0.647
P531	0.45	0.43	0.61	0.156	0.368	0.081	0.171
P532	0.50	0.45	0.48	0.320	0.479	0.296	0.255
D17S579	0.59	0.37	0.60	0.005	0.148	0.003	0.008
THRA1	0.57	0.44	0.51	0.125	0.203	0.328	0.170
D17S250	0.51	0.45	0.54	0.197	0.298	0.185	0.274
D17S588	0.58	0.50	0.58	0.157	0.393	0.153	0.186

Locus	Proportion of alleles IBD					P
Locus		Concordant unaffected	Discordant	Concordant affected	Model 1^a	Model 2^b	Model 3^c	Model 4^d
D2S119	0.43	0.46	0.50	0.558	0.382	0.594	0.546
D2S123	0.38	0.47	0.41	0.841	0.719	0.890	0.862
D3S1277	0.49	0.51	0.64	0.419	0.276	0.422	0.426
D3S1611	0.55	0.54	0.45	0.651	0.267	0.795	0.587
INT2	0.48	0.51	0.40	0.723	0.350	0.802	0.705
ESR	0.46	0.55	0.61	0.711	0.450	0.502	0.647
P531	0.45	0.43	0.61	0.156	0.368	0.081	0.171
P532	0.50	0.45	0.48	0.320	0.479	0.296	0.255
D17S579	0.59	0.37	0.60	0.005	0.148	0.003	0.008
THRA1	0.57	0.44	0.51	0.125	0.203	0.328	0.170
D17S250	0.51	0.45	0.54	0.197	0.298	0.185	0.274
D17S588	0.58	0.50	0.58	0.157	0.393	0.153	0.186

Model 1, no adjustment for measured covariates and variable age at onset.

Model 2, adjustment for variable age at onset.

Model 3, adjustment for nine measured covariates (education, benign breast disease, age at menarche,menopausal status, age at first pregnancy, number of pregnancies, oral contraceptive use, BMI, WHR).

Model 4, adjustment for covariates identified as significant in logistic regression (age at menarche,menstrual status, oral contraceptive use, BMI, and WHR) and variable age at onset.

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