GSTT1, GSTM1, and GSTP1 polymorphisms and RCC risk, by smoking history and BMI
| . | GSTT1 . | . | . | . | . | GSTM1 . | . | . | . | . | GSTP1 . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Cases (%) . | Controls (%) . | OR . | 95% CI . | . | Cases (%) . | Controls (%) . | OR . | 95% CI . | . | Cases (%) . | Controls (%) . | OR . | 95% CI . | |||||||||
| Smokinga | |||||||||||||||||||||||
| Never | |||||||||||||||||||||||
| Present | 27 (69.2) | 138 (79.3) | 1.0 | Present | 19 (48.7) | 86 (49.1) | 1.0 | AA | 17 (42.5) | 73 (45.0) | 1.0 | ||||||||||||
| Null | 12 (30.8) | 36 (20.7) | 2.3 | 0.9–5.7 | Null | 20 (51.3) | 89 (50.9) | 1.0 | 0.4–2.3 | AG or GG | 23 (57.5) | 93 (55.0) | 1.1 | 0.5–2.5 | |||||||||
| Ever | |||||||||||||||||||||||
| Present | 63 (72.4) | 273 (82.7) | 1.0 | Present | 44 (50.6) | 164 (49.7) | 1.0 | AA | 41 (45.6) | 137 (42.6) | 1.0 | ||||||||||||
| Null | 24 (27.6) | 57 (17.3) | 1.7 | 0.8–3.4 | Null | 43 (49.4) | 166 (50.3) | 1.0 | 0.6–1.8 | AG or GG | 49 (54.4) | 185 (57.5) | 0.9 | 0.5–1.6 | |||||||||
| BMIb (tertiles) | |||||||||||||||||||||||
| Low | |||||||||||||||||||||||
| Present | 17 (51.5) | 132 (81.0) | 1.0 | Present | 11 (33.3) | 78 (47.9) | 1.0 | AA | 12 (36.4) | 64 (40.8) | 1.0 | ||||||||||||
| Null | 16 (48.5) | 31 (19.0) | 4.8 | 1.8–13.0 | Null | 22 (66.7) | 85 (52.2) | 2.2 | 0.9–5.6 | AG or GG | 21 (63.6) | 93 (59.2) | 1.2 | 0.5–3.1 | |||||||||
| Middle | |||||||||||||||||||||||
| Present | 33 (73.3) | 141 (82.9) | 1.0 | Present | 23 (51.1) | 77 (45.2) | 1.0 | AA | 22 (47.8) | 75 (44.6) | 1.0 | ||||||||||||
| Null | 12 (26.7) | 29 (17.1) | 1.5 | 0.6–3.9 | Null | 22 (48.9) | 93 (54.7) | 0.7 | 0.3–1.6 | AG or GG | 24 (52.2) | 93 (55.4) | 1.1 | 0.5–2.3 | |||||||||
| High | |||||||||||||||||||||||
| Present | 40 (83.3) | 138 (80.7) | 1.0 | Present | 29 (60.4) | 95 (55.2) | 1.0 | AA | 24 (47.1) | 74 (44.6) | 1.0 | ||||||||||||
| Null | 8 (16.7) | 33 (19.3) | 1.0 | 0.3–2.7 | Null | 19 (39.6) | 77 (44.8) | 0.7 | 0.3–1.6 | AG or GG | 27 (52.9) | 92 (55.4) | 0.8 | 0.4–1.7 | |||||||||
| . | GSTT1 . | . | . | . | . | GSTM1 . | . | . | . | . | GSTP1 . | . | . | . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Cases (%) . | Controls (%) . | OR . | 95% CI . | . | Cases (%) . | Controls (%) . | OR . | 95% CI . | . | Cases (%) . | Controls (%) . | OR . | 95% CI . | |||||||||
| Smokinga | |||||||||||||||||||||||
| Never | |||||||||||||||||||||||
| Present | 27 (69.2) | 138 (79.3) | 1.0 | Present | 19 (48.7) | 86 (49.1) | 1.0 | AA | 17 (42.5) | 73 (45.0) | 1.0 | ||||||||||||
| Null | 12 (30.8) | 36 (20.7) | 2.3 | 0.9–5.7 | Null | 20 (51.3) | 89 (50.9) | 1.0 | 0.4–2.3 | AG or GG | 23 (57.5) | 93 (55.0) | 1.1 | 0.5–2.5 | |||||||||
| Ever | |||||||||||||||||||||||
| Present | 63 (72.4) | 273 (82.7) | 1.0 | Present | 44 (50.6) | 164 (49.7) | 1.0 | AA | 41 (45.6) | 137 (42.6) | 1.0 | ||||||||||||
| Null | 24 (27.6) | 57 (17.3) | 1.7 | 0.8–3.4 | Null | 43 (49.4) | 166 (50.3) | 1.0 | 0.6–1.8 | AG or GG | 49 (54.4) | 185 (57.5) | 0.9 | 0.5–1.6 | |||||||||
| BMIb (tertiles) | |||||||||||||||||||||||
| Low | |||||||||||||||||||||||
| Present | 17 (51.5) | 132 (81.0) | 1.0 | Present | 11 (33.3) | 78 (47.9) | 1.0 | AA | 12 (36.4) | 64 (40.8) | 1.0 | ||||||||||||
| Null | 16 (48.5) | 31 (19.0) | 4.8 | 1.8–13.0 | Null | 22 (66.7) | 85 (52.2) | 2.2 | 0.9–5.6 | AG or GG | 21 (63.6) | 93 (59.2) | 1.2 | 0.5–3.1 | |||||||||
| Middle | |||||||||||||||||||||||
| Present | 33 (73.3) | 141 (82.9) | 1.0 | Present | 23 (51.1) | 77 (45.2) | 1.0 | AA | 22 (47.8) | 75 (44.6) | 1.0 | ||||||||||||
| Null | 12 (26.7) | 29 (17.1) | 1.5 | 0.6–3.9 | Null | 22 (48.9) | 93 (54.7) | 0.7 | 0.3–1.6 | AG or GG | 24 (52.2) | 93 (55.4) | 1.1 | 0.5–2.3 | |||||||||
| High | |||||||||||||||||||||||
| Present | 40 (83.3) | 138 (80.7) | 1.0 | Present | 29 (60.4) | 95 (55.2) | 1.0 | AA | 24 (47.1) | 74 (44.6) | 1.0 | ||||||||||||
| Null | 8 (16.7) | 33 (19.3) | 1.0 | 0.3–2.7 | Null | 19 (39.6) | 77 (44.8) | 0.7 | 0.3–1.6 | AG or GG | 27 (52.9) | 92 (55.4) | 0.8 | 0.4–1.7 | |||||||||
ORs adjusted for age, sex, race,county, and BMI. Tests for interaction: GSTT1 genotype and never/ever smoking, P = 0.60; GSTM1 genotype and never/ever smoking, P = 0.97; GSTP1genotype and never/ever smoking, P = 0.70.
ORs adjusted for age, sex, race, pack-years smoking, and county. Tests for interaction: GSTT1 genotype and tertile BMI, P = 0.07; GSTM1 genotype and tertile BMI, P = 0.13; GSTP1 genotype and tertile BMI, P = 0.76.