American Association for Cancer Research

Table 2

GST M1, T1, and P1 genotypes in RCC cases and controls^a by selected characteristics

	n			GSTM1 (% null)^a,^b			GSTT1 (% null)^a,^b
		Cases	Controls	Case	Control	Case	Control	Case	Control
Sex
Male	94	401	53.9	50.4	26.4	18.3	53.2	57.3
Female	36	104	40.0	51.0	34.3	19.2	61.1	53.9
Age
<45 yr	14	39	57.1	51.3	14.3	18.0	64.3	75.7
45–54 yr	26	87	46.2	49.4	26.9	17.2	61.5	51.2
55–64 yr	46	188	52.3	52.7	38.6	19.7	47.8	55.7
65–74 yr	44	191	47.6	48.7	23.8	17.9	56.8	56.1
Race
White	121	489	48.7	50.5	24.8	18.0	56.2	56.7
African American	4	2	75.0	50.0	75.0	50.0	50.0	50.0
Asian	2	7	100.0	42.9	100.0	42.9	0.0	50.0
Native American	2	3	0.0	33.3	50.0	0.0	50.0	33.3
Other	1	4	100.0	75.0	100.0	25.0	100.0	75.0
Country of birth
United States	120	466	49.2	49.6	28.0	18.5	57.5	56.5
Other	10	39	62.5	61.5	37.5	18.0	30.0	58.3
Hispanic origin
No	128	496	49.2	50.4	29.0	18.2	54.7	56.1
Yes	2	9	100.0	55.6	0.0	33.3	100.0	87.2
County of residence
King	61	55	48.3	61.8	37.9	14.6	50.8	57.4
Pierce	31	20	41.9	45.0	22.6	20.0	67.7	45.0
Skagit	3	72	100.0	44.4	33.3	9.7	33.3	53.5
Snohomish	26	252	57.7	48.8	11.5	17.1	57.7	59.3
Whatcom	9	106	50.0	53.8	37.5	29.3	44.4	54.4
Stage at diagnosis
Local	72		48.6		29.2		56.9
Regional	33		45.5		24.2		57.6
Distant	23		63.2		26.3		47.8
Unstaged	2		50.0		100.0		50.0

	n			GSTM1 (% null)^a,^b			GSTT1 (% null)^a,^b
		Cases	Controls	Case	Control	Case	Control	Case	Control
Sex
Male	94	401	53.9	50.4	26.4	18.3	53.2	57.3
Female	36	104	40.0	51.0	34.3	19.2	61.1	53.9
Age
<45 yr	14	39	57.1	51.3	14.3	18.0	64.3	75.7
45–54 yr	26	87	46.2	49.4	26.9	17.2	61.5	51.2
55–64 yr	46	188	52.3	52.7	38.6	19.7	47.8	55.7
65–74 yr	44	191	47.6	48.7	23.8	17.9	56.8	56.1
Race
White	121	489	48.7	50.5	24.8	18.0	56.2	56.7
African American	4	2	75.0	50.0	75.0	50.0	50.0	50.0
Asian	2	7	100.0	42.9	100.0	42.9	0.0	50.0
Native American	2	3	0.0	33.3	50.0	0.0	50.0	33.3
Other	1	4	100.0	75.0	100.0	25.0	100.0	75.0
Country of birth
United States	120	466	49.2	49.6	28.0	18.5	57.5	56.5
Other	10	39	62.5	61.5	37.5	18.0	30.0	58.3
Hispanic origin
No	128	496	49.2	50.4	29.0	18.2	54.7	56.1
Yes	2	9	100.0	55.6	0.0	33.3	100.0	87.2
County of residence
King	61	55	48.3	61.8	37.9	14.6	50.8	57.4
Pierce	31	20	41.9	45.0	22.6	20.0	67.7	45.0
Skagit	3	72	100.0	44.4	33.3	9.7	33.3	53.5
Snohomish	26	252	57.7	48.8	11.5	17.1	57.7	59.3
Whatcom	9	106	50.0	53.8	37.5	29.3	44.4	54.4
Stage at diagnosis
Local	72		48.6		29.2		56.9
Regional	33		45.5		24.2		57.6
Distant	23		63.2		26.3		47.8
Unstaged	2		50.0		100.0		50.0

Results from 132 cases and 505 controls with DNA available, of 173 cases and 614 controls interviewed. The number of subjects with genotype results was 126 cases and 505 controls for GSTM1; 126 cases and 504 controls for GSTT1;and 130 cases and 491 controls for GSTP1.

Percentage of genotyped subjects in each category homozygous null for GSTM1 or GSTT1.

Percentage of genotyped subjects in each category heterozygous or homozygous for GSTP1 exon 5 A/G.

View Large

This Feature Is Available To Subscribers Only