American Association for Cancer Research

Table 2

History of benign thyroid disease: Los Angeles County females, 15–54 years of age

	Ca/Co^a	OR	95% CI
Hypothyroid
>1 yr before diagnosis	41/35	1.2	0.7–2.0
>5 yr before diagnosis	38/30	1.3	0.8–2.2
>10 yr before diagnosis	30/25	1.2	0.7–2.3
Hyperthyroid
>1 yr before diagnosis	14/8	2.0	0.7–6.5
>5 yr before diagnosis	12/4	3.0	0.9–12.8
>10 yr before diagnosis	8/4	2.0	0.5–9.1
Thyroid enlargement as an adolescent^b
>1 yr before diagnosis	14/2	7.0	1.6–63.5
>5 yr before diagnosis	9/2	4.5	0.9–42.8
>10 yr before diagnosis	5/2	2.5	0.4–26.2
Goiter
>1 yr before diagnosis	22/5	4.4	1.6–14.9
>5 yr before diagnosis	15/4	3.8	1.2–15.5
>10 yr before diagnosis	9/3	3.0	0.8–17.2
Nodules or benign tumors
>1 yr before diagnosis	42/1	42.0	7.1–1697.9
>5 yr before diagnosis	24/0	∞	6.0–∞
>10 yr before diagnosis	9/0	∞	2.0–∞

	Ca/Co^a	OR	95% CI
Hypothyroid
>1 yr before diagnosis	41/35	1.2	0.7–2.0
>5 yr before diagnosis	38/30	1.3	0.8–2.2
>10 yr before diagnosis	30/25	1.2	0.7–2.3
Hyperthyroid
>1 yr before diagnosis	14/8	2.0	0.7–6.5
>5 yr before diagnosis	12/4	3.0	0.9–12.8
>10 yr before diagnosis	8/4	2.0	0.5–9.1
Thyroid enlargement as an adolescent^b
>1 yr before diagnosis	14/2	7.0	1.6–63.5
>5 yr before diagnosis	9/2	4.5	0.9–42.8
>10 yr before diagnosis	5/2	2.5	0.4–26.2
Goiter
>1 yr before diagnosis	22/5	4.4	1.6–14.9
>5 yr before diagnosis	15/4	3.8	1.2–15.5
>10 yr before diagnosis	9/3	3.0	0.8–17.2
Nodules or benign tumors
>1 yr before diagnosis	42/1	42.0	7.1–1697.9
>5 yr before diagnosis	24/0	∞	6.0–∞
>10 yr before diagnosis	9/0	∞	2.0–∞

Ca/Co, number of exposed cases/number of exposed controls.

Includes only physician-diagnosed thyroid enlargement.