Associations between MTHFR and high- and low-risk diets as determined by combined levels of folate, methionine, and alcohola
| MTHFR genotype . | OR (95% CI)b . | . | . | ||
|---|---|---|---|---|---|
| . | High risk . | Intermediate risk . | Low risk . | ||
| CC/TT cases/controls | 109/96 | 1180/1449 | 39/64 | ||
| TT cases/controls | 11/10 | 121/179 | 7/18 | ||
| All subjects | |||||
| CC/CT | 1.0 | 0.8 (0.6–1.0) | 0.6 (0.4–1.0) | ||
| TT | 1.0 (0.4–2.4) | 0.7 (0.5–1.0) | 0.4 (0.1–0.9) | ||
| Subjects ≤60 years | |||||
| CC/CT | 1.0 | 0.7 (0.4–1.2) | 0.6 (0.2–1.9) | ||
| TT | 0.6 (0.1–2.6) | 0.8 (0.4–1.7) | 0.2 (0.02–1.8) | ||
| Subjects ≤60 years | |||||
| CC/CT | 1.0 | 0.8 (0.5–1.0) | 0.6 (0.3–1.0) | ||
| TT | 1.3 (0.4–4.5) | 0.6 (0.4–0.9) | 0.4 (0.2–1.2) | ||
| MTHFR genotype . | OR (95% CI)b . | . | . | ||
|---|---|---|---|---|---|
| . | High risk . | Intermediate risk . | Low risk . | ||
| CC/TT cases/controls | 109/96 | 1180/1449 | 39/64 | ||
| TT cases/controls | 11/10 | 121/179 | 7/18 | ||
| All subjects | |||||
| CC/CT | 1.0 | 0.8 (0.6–1.0) | 0.6 (0.4–1.0) | ||
| TT | 1.0 (0.4–2.4) | 0.7 (0.5–1.0) | 0.4 (0.1–0.9) | ||
| Subjects ≤60 years | |||||
| CC/CT | 1.0 | 0.7 (0.4–1.2) | 0.6 (0.2–1.9) | ||
| TT | 0.6 (0.1–2.6) | 0.8 (0.4–1.7) | 0.2 (0.02–1.8) | ||
| Subjects ≤60 years | |||||
| CC/CT | 1.0 | 0.8 (0.5–1.0) | 0.6 (0.3–1.0) | ||
| TT | 1.3 (0.4–4.5) | 0.6 (0.4–0.9) | 0.4 (0.2–1.2) | ||
Low risk was defined as folate ≥195 μg per 1000 calories, methionine, ≥1.0 g per 1000 calories and non-alcoholic beverage drinker. High risk was defined as folate ≤140 μg per 1000 calories, methionine ≤0.80 g per 1000 calories, and alcohol >10 g per day. Values between those for low and high are considered intermediate.
Nutrients were evaluated as nutrients per 1000 kcal and adjusted for sex and age.