Associations between nutrients and MTHFR status in men and women
| MTHFR genotype . | OR (95% CI)a . | . | . | ||
|---|---|---|---|---|---|
| . | Low . | Intermediate . | High . | ||
| Folateb | |||||
| CC | 1.0 | 0.8 (0.7–1.1) | 0.8 (0.6–1.2) | ||
| CT | 1.0 (0.8–1.3) | 0.9 (0.7–1.2) | 0.8 (0.6–1.1) | ||
| TT | 0.8 (0.5–1.3) | 0.8 (0.6–1.2) | 0.6 (0.4–1.0) | ||
| Vitamin B6 | |||||
| CC | 1.0 | 0.8 (0.6–1.0) | 0.9 (0.7–1.3) | ||
| CT | 0.9 (0.7–1.2) | 0.9 (0.7–1.2) | 0.9 (0.6–1.2) | ||
| TT | 0.8 (0.5–1.3) | 0.8 (0.6–1.2) | 0.6 (0.4–1.0) | ||
| Vitamin B12 | |||||
| CC | 1.0 | 1.1 (0.8–1.4) | 1.0 (0.8–1.4) | ||
| CT | 1.1 (0.7–1.9) | 1.1 (0.9–1.4) | 0.9 (0.6–1.2) | ||
| TT | 1.2 (0.7–1.9) | 0.9 (0.6–1.2) | 0.7 (0.5–1.2) | ||
| Methionine | |||||
| CC | 1.0 | 0.9 (0.7–1.2) | 0.8 (0.6–1.0) | ||
| CT | 1.0 (0.7–1.3) | 0.9 (0.7–1.2) | 0.9 (0.6–1.2) | ||
| TT | 0.9 (0.5–1.4) | 0.7 (0.5–1.0) | 0.8 (0.5–1.3) | ||
| Alcohol | |||||
| CC | 1.0 | 0.9 (0.7–1.2) | 0.8 (0.6–1.1) | ||
| CT | 0.9 (0.7–1.1) | 1.0 (0.8–1.3) | 1.2 (0.9–1.6) | ||
| TT | 1.0 (0.7–1.4) | 0.5 (0.3–0.8) | 1.0 (0.6–1.6) | ||
| Multivitamin supplementc | |||||
| CC | 1.0 | 1.1 (0.9–1.3) | |||
| CT | 1.0 (0.8–1.2) | 1.1 (0.9–1.4) | |||
| TT | 0.9 (0.7–1.2) | 0.9 (0.6–1.3) | |||
| MTHFR genotype . | OR (95% CI)a . | . | . | ||
|---|---|---|---|---|---|
| . | Low . | Intermediate . | High . | ||
| Folateb | |||||
| CC | 1.0 | 0.8 (0.7–1.1) | 0.8 (0.6–1.2) | ||
| CT | 1.0 (0.8–1.3) | 0.9 (0.7–1.2) | 0.8 (0.6–1.1) | ||
| TT | 0.8 (0.5–1.3) | 0.8 (0.6–1.2) | 0.6 (0.4–1.0) | ||
| Vitamin B6 | |||||
| CC | 1.0 | 0.8 (0.6–1.0) | 0.9 (0.7–1.3) | ||
| CT | 0.9 (0.7–1.2) | 0.9 (0.7–1.2) | 0.9 (0.6–1.2) | ||
| TT | 0.8 (0.5–1.3) | 0.8 (0.6–1.2) | 0.6 (0.4–1.0) | ||
| Vitamin B12 | |||||
| CC | 1.0 | 1.1 (0.8–1.4) | 1.0 (0.8–1.4) | ||
| CT | 1.1 (0.7–1.9) | 1.1 (0.9–1.4) | 0.9 (0.6–1.2) | ||
| TT | 1.2 (0.7–1.9) | 0.9 (0.6–1.2) | 0.7 (0.5–1.2) | ||
| Methionine | |||||
| CC | 1.0 | 0.9 (0.7–1.2) | 0.8 (0.6–1.0) | ||
| CT | 1.0 (0.7–1.3) | 0.9 (0.7–1.2) | 0.9 (0.6–1.2) | ||
| TT | 0.9 (0.5–1.4) | 0.7 (0.5–1.0) | 0.8 (0.5–1.3) | ||
| Alcohol | |||||
| CC | 1.0 | 0.9 (0.7–1.2) | 0.8 (0.6–1.1) | ||
| CT | 0.9 (0.7–1.1) | 1.0 (0.8–1.3) | 1.2 (0.9–1.6) | ||
| TT | 1.0 (0.7–1.4) | 0.5 (0.3–0.8) | 1.0 (0.6–1.6) | ||
| Multivitamin supplementc | |||||
| CC | 1.0 | 1.1 (0.9–1.3) | |||
| CT | 1.0 (0.8–1.2) | 1.1 (0.9–1.4) | |||
| TT | 0.9 (0.7–1.2) | 0.9 (0.6–1.3) | |||
Nutrients were evaluated as nutrients per 1000 kcal and adjusted for sex, age, BMI, long-term vigorous physical activity, usual number of cigarettes smoked per day, total energy intake, and dietary fiber.
Cut-off points for men were: folate, 126/197; vitamin B6, 0.8/1.2; vitamin B12, 1.9/3.31; methionine, 0.74/1.0; alcohol, 1/20. Cut-off points for women were: folate, 141/214; vitamin B6, 0.85/1.21; vitamin B12, 1.88/3.31; methionine, 0.75/1.0; alcohol, 1/20.
Includes any reported use of multivitamin supplements or any supplement that contains folate or B vitamins during the referent year. Low, used no multivitamin supplement; High, used multivitamin supplement.